Can a daily microdose of psilocybin calm chronic anxiety?
NCT ID NCT06969170
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial investigates whether a low-dose psilocybin oral solution can safely ease symptoms of generalized anxiety disorder (GAD). Adults aged 18-60 with a GAD diagnosis and moderate-to-severe anxiety will first receive open-label psilocybin for four weeks, then those who respond will be randomly assigned to continue psilocybin or switch to a placebo for another four weeks. Researchers will track side effects, anxiety scores, and brain activity to see if this approach holds promise as a daily treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- psilocybin oral solution
- What this could lead to
- If successful, this could point toward a new daily, low-dose treatment option for generalized anxiety disorder.
- What could go wrong
- This is an early-phase trial with only 50 participants, so results may not hold up in larger studies. Psilocybin can cause side effects, and the placebo comparison is limited to a short double-blind phase.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Kingston General Health Research Institute
RECRUITINGKingston, Ontario, K7L 2V7, Canada
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