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Brain zapping without surgery: new device targets deep brain regions to treat depression and anxiety

NCT ID NCT07712159

Not yet recruiting Symptom relief Sponsor: Central South University Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This clinical trial is testing a non-invasive brain stimulation method called temporal interference transcranial alternating current stimulation (TI-tACS) for people with major depressive disorder or generalized anxiety disorder. The device uses two high-frequency electrical currents to create a low-frequency field deep in the brain, targeting the right amygdala. Participants receive 20 sessions over two weeks and are followed for up to six months to see if symptoms improve compared to a sham (inactive) treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Temporal Interference transcranial Alternating Current Stimulation (TI-tACS), a non-invasive brain stimulation device that uses two high-frequency currents to target deep brain regions like the right amygdala
What this could lead to
If effective, TI-tACS could offer a new, non-invasive treatment option for people with depression or anxiety who haven't responded well to medication.
What could go wrong
This is an early-stage trial with a relatively small sample size, and the effects may not be large or lasting. The sham-controlled design means some participants may not receive active stimulation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

generalized anxiety disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED ANXIETY DISORDER (GAD) MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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