Can an AI therapist match a human one? new trial aims to find out
NCT ID NCT07620340
First seen Jun 03, 2026 · Last updated Jun 19, 2026 · Updated 6 times
Summary
This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The goal is to see if the AI approach works as well as traditional therapy in reducing symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AI-guided digital cognitive behavioural therapy (CBT) with clinician oversight
What this could lead to
If it works, this could offer a more accessible, scalable alternative to traditional therapy for depression and anxiety.
What could go wrong
This is an early-stage non-inferiority trial; the AI therapy may not be as effective as human-led CBT, and results may not apply to severe cases.
Conditions
Explore the condition pages connected to this study.
Standardized tags
Added by Cure My DiseaseWe match each trial to standard medical vocabularies so it's findable however the registrant phrased it. These tags are added by us and may differ from the conditions listed above.