Can an AI therapist match a human one? new trial aims to find out
NCT ID NCT07620340
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The goal is to see if the AI approach works as well as traditional therapy in reducing symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AI-guided digital cognitive behavioural therapy (CBT) with clinician oversight
- What this could lead to
- If it works, this could offer a more accessible, scalable alternative to traditional therapy for depression and anxiety.
- What could go wrong
- This is an early-stage non-inferiority trial; the AI therapy may not be as effective as human-led CBT, and results may not apply to severe cases.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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