New weekly pill could ease depression symptoms

NCT ID NCT06547489

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new oral drug called zelquistinel can reduce depression symptoms in adults with major depressive disorder. Participants take one tablet weekly for 6 weeks and have their depression severity checked at each clinic visit. The trial compares the drug against a placebo to see if it works and is safe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Andes Clinical Research

    RECRUITING

    Orem, Utah, 84097, United States

  • Austin Clinical Trial Partners

    RECRUITING

    Austin, Texas, 78737, United States

  • Baylor College of Medicine, Psychiatry and Behavioral Sciences

    WITHDRAWN

    Houston, Texas, 77030, United States

  • Boston Clinical Trials

    WITHDRAWN

    Boston, Massachusetts, 02131, United States

  • CalNeuro Research Group

    RECRUITING

    Los Angeles, California, 90025, United States

  • CenExel iRS (iResearch Savannah)

    RECRUITING

    Savannah, Georgia, 31405, United States

  • Clinical Neuroscience Solutions, Inc.

    RECRUITING

    Jacksonville, Florida, 32256, United States

  • Clinical Neuroscience Solutions, Inc.

    RECRUITING

    Orlando, Florida, 32801, United States

  • Clinical Neuroscience Solutions, Inc.

    WITHDRAWN

    Memphis, Tennessee, 38119, United States

  • Clinical Trials of Texas LLC

    WITHDRAWN

    San Antonio, Texas, 78229, United States

  • D&H Pompano Research Center, LLC

    RECRUITING

    Margate, Florida, 33063, United States

  • Grayline Research Center

    RECRUITING

    Wichita Falls, Texas, 76309, United States

  • InSite Clinical Research, LLC

    RECRUITING

    DeSoto, Texas, 75115, United States

  • Insight Clinical Trials LLC

    RECRUITING

    Independence, Ohio, 44131, United States

  • Irvine Clinical Research

    RECRUITING

    Irvine, California, 92614, United States

  • KUMC-Wichita

    RECRUITING

    Wichita, Kansas, 66160, United States

  • Lehigh Center for Clinical Research

    RECRUITING

    Allentown, Pennsylvania, 18103, United States

  • MCB Clinical Research Centers, Inc.

    RECRUITING

    Colorado Springs, Colorado, 80910, United States

  • Mayflower Clinical

    RECRUITING

    Russells Mills, Massachusetts, 02747, United States

  • Miami Dade Medical Research Institute

    RECRUITING

    Miami, Florida, 33176, United States

  • Mountain View Clinical Research

    RECRUITING

    Denver, Colorado, 80209, United States

  • Neurobehavioral Research, Inc.

    RECRUITING

    Cedarhurst, New York, 11516, United States

  • Northwest Clinical Research Center

    WITHDRAWN

    Bellevue, Washington, 98007, United States

  • Pacific Clinical Research Management Group LLC

    TERMINATED

    Upland, California, 91786, United States

  • Premier Clinical Research Institute, Inc.

    RECRUITING

    Miami, Florida, 33122, United States

  • Quantum Research Associates Corp.

    ACTIVE_NOT_RECRUITING

    Louisville, Kentucky, 40218, United States

  • Revive Research Institute

    WITHDRAWN

    Elgin, Illinois, 60123, United States

  • Sooner Clinical Research, Inc.

    WITHDRAWN

    Oklahoma City, Oklahoma, 73116, United States

  • Sunwise Clinical Research LLC

    RECRUITING

    Walnut Creek, California, 94549, United States

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • University of Alabama at Birmingham-Huntsville

    RECRUITING

    Huntsville, Alabama, 35801, United States

  • University of Connecticut School of Medicine Psychiatry Department

    RECRUITING

    Farmington, Connecticut, 06030, United States

  • Vector Clinical Trials

    RECRUITING

    Las Vegas, Nevada, 89128, United States

  • Wr-Pri, Llc

    WITHDRAWN

    Encino, California, 91316, United States