Mouth spray could tame agonizing swallowing pain during cancer radiation
NCT ID NCT06017895
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This clinical trial tests whether a doxepin solution spray can relieve severe breakthrough pain when swallowing, a common side effect of radiation therapy for nasopharyngeal carcinoma. About 178 patients will be randomly assigned to receive either the doxepin spray or a placebo spray. Researchers will measure pain reduction and any drowsiness at several time points after use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- doxepin solution
- What this could lead to
- If effective, this spray could offer quick relief from severe swallowing pain during radiotherapy, improving quality of life for patients with nasopharyngeal carcinoma.
- What could go wrong
- This is a relatively small, early-stage trial. The spray may cause drowsiness or other side effects, and its pain-relieving effect may not be strong enough to be clinically useful.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Southern medical university
RECRUITINGGuangzhou, Guangdong, 510515, China