Tailored drug regimen shows promise for rare blood disorder

NCT ID NCT04720261

Terminated Disease control Sponsor: University Hospital, Rouen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving the drug caplacizumab based on regular blood tests (ADAMTS13 activity) could improve outcomes for adults with acquired thrombotic thrombocytopenic purpura (aTTP), a rare condition causing dangerous blood clots. The trial enrolled 58 adults and monitored for death, lack of response, or worsening disease within 30 days. The goal was to see if a personalized approach could reduce complications while using the drug more efficiently.

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Conditions

The condition(s) this trial relates to.

acquired thrombotic thrombocytopenic purpura

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THROMBOTIC THROMBOCYTOPENIC PURPURA, ACQUIRED

Contacts and locations

Locations

Ah-Hp Hopital Saint Louis

Paris, 75010, France
Ap-Hm Hopital de La Conception

Marseille, 13005, France
Ap-Hp Hopital de Cochin

Paris, 75014, France
Ap-Hp Hopital de Necker

Paris, 75015, France
Ap-Hp Hopital de St Antoine

Paris, 75571, France
CHU CAEN

Caen, 14033, France
Ch Edouard Herriot

Lyon, 69003, France
Ch Valenciennes

Valenciennes, 59300, France
Chu Amiens

Amiens, 80054, France
Chu Angers

Angers, 49933, France
Chu Besancon

Besançon, 25030, France
Chu Bordeaux

Bordeaux, 33404, France
Chu Clermont-Ferrand

Clermont-Ferrand, 63003, France
Chu Lille

Lille, 59037, France
Chu Limoges

Limoges, 87042, France
Chu Montpellier

Montpellier, 34295, France
Chu Nancy

Nancy, 54035, France
Chu Nantes

Nantes, 44093, France
Chu Reims

Reims, 51092, France
Chu Rennes

Rennes, 35033, France
Chu Rouen

Rouen, 76031, France
Chu Tours

Tours, 37044, France
Fort de France

Fort-de-France, 97261, Martinique
Reunion Sud

Saint-Paul, 97448, France

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