Gene combo clues could spot High-Risk colon cancer families
NCT ID NCT01057953
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether certain combinations of genetic variations, rather than a single gene, can increase the risk of colorectal cancer. Researchers will compare the DNA of 700 patients with strong family histories of the disease against 350 healthy controls. The goal is to better understand non-Mendelian genetic risk and potentially improve screening recommendations for at-risk relatives.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help identify families at high genetic risk for colorectal cancer, leading to earlier and more targeted screening.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear genetic patterns, and results may not change current screening practices.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CH de Niort
Niort, France
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CHRU de Lille
Lille, France
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CHU de Dijon
Dijon, France
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CHU de Grenoble
Grenoble, France
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CHU de Montpellier
Montpellier, France
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CHU de Rennes
Rennes, France
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CHU de Saint-Etienne
Saint-Etienne, France
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CHU de Toulouse
Toulouse, France
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CLCC Val d'Aurelle
Montpellier, France
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Centre Eugène Marquis
Rennes, 35000, France
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Centre François Baclesse
Caen, 14000, France
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Hôpital Européen Georges Pompidou
Paris, France
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Institut Claudius Regaud
Toulouse, France
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Institut Curie
Paris, 75005, France
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Institut Gustave Roussy
Villejuif, 94800, France
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UHRouen
Rouen, 76031, France