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Heart surgery patients get ketamine: inflammation drops?

NCT ID NCT07536633

Symptom relief Sponsor: Konya City Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

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Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether giving ketamine during heart surgery can lower inflammation and pain afterward. 177 adults having planned heart surgery were split into two groups: one got ketamine, the other did not. Researchers measured blood markers of inflammation and asked about pain to see if ketamine helped recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

177 people

The number who actually took part.

Started

Oct 2022

Finished

May 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Patients aged 18-80 years. * Scheduled to undergo elective cardiac surgery. * Able to provide informed consent. * Able to reliably communicate symptoms to the research team. Exclusion Criteria * Contraindications to anesthesia. * Cognitive impairment or communication barriers. * End-stage renal failure (receiving routine hemodialysis). * Pregnancy or breastfeeding. * Known allergy to ketamine. * Ejection fraction (EF) \<35%. * Emergency or repeat surgery. * Arrhythmia. * Morbid obesity. * Psychiatric disorders. * Hepatic failure. * Use of anti-inflammatory medications. * Preoperative white blood cell count (leukocyte) ≥15 × 10³/µL. * C-reactive protein (CRP) ≥30 mg/L. * Declined to participate in the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery

Contacts and locations

Locations

  • Necmettin Erbakan University Meram Faculty of Medicine Hospital

    Meram, Konya, 42000, Turkey (Türkiye)

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