Heart drug shows promise in preventing post-surgery rhythm disorder

NCT ID NCT04607122

Completed Prevention Sponsor: CMC Ambroise Paré Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a low-dose infusion of landiolol, a short-acting beta-blocker, could prevent atrial fibrillation in 400 non-Asian patients after cardiac surgery. Participants received either landiolol or a placebo for up to 48 hours after surgery. The goal was to see if landiolol reduces the occurrence of this common and serious complication without causing more side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Landiolol (a short-acting beta-blocker)
What this could lead to: If it works, this could provide a safe way to prevent a common heart rhythm problem after heart surgery, reducing hospital stays and complications.
What could go wrong: This is a phase 3 trial, but previous positive results were in Japanese patients only. It may not work as well in non-Asian populations, and side effects like low blood pressure or slow heart rate are possible.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION CARDIAC SURGERY

Contacts and locations

Locations

CMC Ambroise Paré

Neuilly-sur-Seine, 92200, France
Centre Cardiologique du Nord

Saint-Denis, 93200, France
Hôpital Privé Jacques Cartier

Massy, 91300, France

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