Can your genes predict painkiller side effects? new study investigates

NCT ID NCT05612399

Not yet recruiting Knowledge-focused Sponsor: Kathirvel Subramaniam Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will enroll 400 older adults (over 60) having heart surgery to see if genetic differences affect how well methadone and oxycodone work and their side effects. Researchers will measure pain, nausea, breathing problems, and sedation. The goal is to personalize pain treatment and reduce opioid-related risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: methadone and oxycodone
What this could lead to: If successful, this could lead to personalized pain management after heart surgery, reducing side effects like nausea and breathing problems.
What could go wrong: This is an early-stage study focused on genetics, not a new treatment. It may not change current practice, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA CARDIAC SURGERY

Contacts and locations

Locations

UPMC Presbyterian Hospital

Pittsburgh, Pennsylvania, 15213, United States

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