Can a simple gas save lives after heart surgery? major trial launches
NCT ID NCT06702553
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether giving inhaled nitric oxide during and after heart surgery can lower the risk of death or major complications like kidney failure, stroke, and heart failure. About 3,650 adults having elective heart surgery with a heart-lung machine will receive either nitric oxide or a placebo gas. The goal is to see if this treatment reduces the need for intensive life support within 30 days after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
inhaled nitric oxide gas
What this could lead to
If it works, this could become a standard treatment to prevent life-threatening complications like kidney failure, stroke, or heart failure after heart surgery.
What could go wrong
Earlier smaller studies showed benefits in lab tests but not in survival or recovery. This large trial aims to confirm if those benefits are real, but it may still fail to improve hard outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cardiology Research Institute, Tomsk National Research Medical Center
NOT_YET_RECRUITINGTomsk, 634012, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital, Department of Anesthesia, Critical Care and Pain Medicine
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xijing Hospital
RECRUITINGXi'an, Shaanxi, 710032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••