Can a simple gas save lives after heart surgery? major trial launches

NCT ID NCT06702553

Recruiting now Disease control Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether giving inhaled nitric oxide during and after heart surgery can lower the risk of death or major complications like kidney failure, stroke, and heart failure. About 3,650 adults having elective heart surgery with a heart-lung machine will receive either nitric oxide or a placebo gas. The goal is to see if this treatment reduces the need for intensive life support within 30 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: inhaled nitric oxide gas
What this could lead to: If it works, this could become a standard treatment to prevent life-threatening complications like kidney failure, stroke, or heart failure after heart surgery.
What could go wrong: Earlier smaller studies showed benefits in lab tests but not in survival or recovery. This large trial aims to confirm if those benefits are real, but it may still fail to improve hard outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADULT PATIENTS UNDERGOING CARDIOVASCULAR SURGERY WITH CARDIOPULMONARY BYPASS CARDIAC SURGERY CARDIOPULMONARY BYPASS NITRIC OXIDE

Contacts and locations

Locations

Cardiology Research Institute, Tomsk National Research Medical Center
NOT_YET_RECRUITING

Tomsk, 634012, Russia
Massachusetts General Hospital, Department of Anesthesia, Critical Care and Pain Medicine
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Xijing Hospital
RECRUITING

Xi'an, Shaanxi, 710032, China

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