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Ultrasound-Guided diuretic strategy may boost kidney recovery after cardiac surgery

NCT ID NCT06251713

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This pilot trial tests whether using an ultrasound score (VeXUS) to guide fluid removal with diuretics can help kidneys recover in patients who develop acute kidney injury after cardiac surgery. About 40 participants will be randomly assigned to either VeXUS-guided fluid management or usual care. The main goal is to see if a larger trial is feasible.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
VeXUS score guided fluid management strategy using diuretics (furosemide and thiazide)
What this could lead to
If successful, this approach could point toward a better way to manage fluid balance in post-surgery kidney injury, potentially improving recovery and reducing long-term complications.
What could go wrong
This is a small pilot study testing feasibility, not effectiveness. The strategy may not improve outcomes or could cause electrolyte imbalances or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Intensive care unit admission within 72 hours of cardiac surgery with extracorporeal circulation * Acute kidney injury defined by KDIGO criteria * Vasoactive inotropic score \<45 and capillary refill time \<3s * Informed written consent Exclusion Criteria: * Hypokalaemia \<3.5mmol/L * Hyponatremia\<125mmol/L * Hypernatremia \>145mmol/L * Metabolic alkalosis with pH \>7.50 * Impossibility to measure capillary refill time * Chronic liver disease * Cirrhosis with portal hypertension * Known thrombus of the inferior vena cava * Mechanical circulatory assistance (ECMO or mono left ventricular assistance) * Severe pre-operative chronic kidney disease (GFR \< 30mL/min/1.73m2) * Need for renal replacement therapy anticipated by the attending physician within 24 hours * Known hypersensitivity to Furosemide and/or hydrochlorothiazide * Severe allergy to wheat * Patient already included in another interventional study with an exclusion period still in progress * Pregnant, breast-feeding or women of childbearing age without suitable contraception * Patients under guardianship, curatorship or safeguard of justice * Patients under psychiatric care * Patients not affiliated to a social security scheme or beneficiaries of a similar scheme

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Conditions

The condition(s) this trial relates to.

acute kidney injury Hyperemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Cardiac surgery Hemodynamic stability Venous congestion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hopital cardiologique Louis Pradel

    RECRUITING

    Bron, France

  • Hôpital Louis Pradel, Groupement Hospitalier Est, Hospices Civils de Lyon

    NOT_YET_RECRUITING

    Bron, Bron, 69500, France

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