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A simple protein test might flag kidney danger after heart surgery

NCT ID NCT07803328

Knowledge-focused Sponsor: Universität Münster Source: ClinicalTrials.gov ↗

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Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 03, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study asks whether levels of a protein called vascular endothelial growth factor (VEGF) in blood and urine can predict which patients will develop acute kidney injury after heart surgery that uses a heart-lung machine. Researchers will follow 220 adults having planned heart surgery and compare VEGF levels between those who do and do not develop kidney problems. The goal is to find a warning sign that could help doctors act sooner.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If VEGF levels reliably predict kidney injury, doctors could identify high-risk patients early and tailor monitoring or protective care after heart surgery.
What could go wrong
This is an observational study, not a treatment test. It may show only a weak link, and results may not apply to emergency surgeries or patients with severe kidney disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 220 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients undergoing elective cardiac surgery with use of cardiopulmonary bypass

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years 2. Elective cardiac surgery using cardiopulmonary bypass 3. Written informed consent Exclusion Criteria: 1. Pre-existing chronic kidney disease with an eGFR \<20 ml/min/1,73m2 2. Usage of VEGF-inhibitors 3. Patients with pre-existing AKI within the last 30 days 4. Patients undergoing one of the following surgeries: 1. Emergency surgery 2. LVAD-implantation 5. Patients after cardiac arrest requiring cardiopulmonary resuscitation within the last 6 months 6. Patients on vasopressors, inotropes or mechanical circulatory support before surgery

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Cardiac surgery associated - acute kidney injury

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • University Muenster, University Hospital Muenster, Department of Anesthesiology, Intensive Care and Pain Medicineperative

    Münster, 48149, Germany

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