Can a simple inhaled antibiotic stop deadly pneumonia in ventilator patients?
NCT ID NCT07665788
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a 5-day course of inhaled amikacin can prevent ventilator-associated pneumonia in critically ill patients who already have a milder airway infection called tracheobronchitis. 250 adults on breathing machines will receive either the drug or a placebo. The goal is to see if the treatment reduces the chance of the infection spreading to the lungs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- inhaled amikacin
- What this could lead to
- If it works, this could offer a way to prevent a serious lung infection in critically ill patients on breathing machines.
- What could go wrong
- This is an early-stage trial with only 250 participants, so results may not apply to all patients. The treatment may not prevent pneumonia and could have side effects like kidney issues or hearing loss.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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01 - ORLEANS - Intensive care, University Hospital
Orléans, 45000, France
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02 - TOURS - Intensive care, University Hospital
Tours, 37044, France
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03 - STRASBOURG - Intensive care, University Hospital
Strasbourg, 67091, France
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04 - ARGENTEUIL - Intensive care, University Hospital
Argenteuil, France
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05 - LE MANS - Intensive care, University Hospital
Le Mans, 72037, France
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06 - ANGERS - Intensive care, University Hospital
Angers, 49933, France
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07 - DIEPPE - Intensive care, University Hospital
Dieppe, 76202, France
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08 - DIJON - Intensive care, University Hospital
Dijon, 21000, France
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09 - BOURG-EN-BRESSE, Intensive care, Hospital
Bourg-en-Bresse, 01012, France
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10 - HENRI MONDOR, Intensive care, University Hospital
Créteil, 94010, France
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11 - BLOIS, Intensive care, Hospital
Blois, France
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12 - DREUX, Intensive care, Hospital
Dreux, 28100, France
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13 - BICHAT, Intensive care, Univerity Hospital
Paris, France
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14 - VERSAILLES, Intensive care, Hospital
Le Chesnay, 78150, France
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15 - LYON EH, Intensive care, University Hospital
Lyon, 69437, France
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16 - LYON SUD, Intensive care, University Hospital
Pierre-Bénite, 69495, France
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17 - LOUIS MOURIER, Intensive care, University Hospital
Paris, 32700, France
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