Antibiotics or watchful waiting? a trial puts ventilator tracheobronchitis to the test

NCT ID NCT05266066

Ongoing Disease control Sponsor: Hospital Sirio-Libanes Source: ClinicalTrials.gov ↗

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial tests whether giving antibiotics for a week is better than simply monitoring patients who develop ventilator-associated tracheobronchitis, a lung airway infection common in ICU patients on breathing machines. Researchers will compare how many days patients are free from the ventilator and whether pneumonia or death occurs. The goal is to see if avoiding antibiotics is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics (7-day course) versus clinical observation without antibiotics
What this could lead to: If observation alone proves non-inferior, it could reduce unnecessary antibiotic use in ICUs, lowering side effects and resistance.
What could go wrong: This is a non-inferiority trial, so it may not prove observation is better—only that it's not much worse. Risks include missing a hidden infection without antibiotics.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Critical Illness tracheobronchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRACHEOBRONCHITIS VENTILATOR ASSOCIATED TRACHEOBRONCHITIS

Contacts and locations

Locations

Hospital Ernesto Dornelles

Porto Alegre, Rio Grande do Sul, Brazil
Hospital Estadual Mario Covas

Santo André, São Paulo, Brazil
Hospital Itapetininga

Itapetininga, São Paulo, Brazil
Hospital Municipal de Maringá

Maringá, Paraná, Brazil
Hospital OTOClinica

Fortaleza, Ceará, Brazil
Hospital Samaritano

São Paulo, São Paulo, Brazil
Hospital Santa Casa de Belo Horizonte

Belo Horizonte, Minas Gerais, Brazil
Hospital Santa Casa de Sorocaba

Sorocaba, São Paulo, Brazil
Hospital São Joao Del Rei

São João del Rei, Minas Gerais, Brazil
Hospital São Paulo

São Paulo, São Paulo, Brazil
Hospital Tricentenário

Olinda, Pernambuco, Brazil
Hospital Unimed Limeira

Limeira, São Paulo, Brazil
Hospital Universitário Regional do Norte do Paraná

Londrina, Paraná, Brazil
Hospital Vila Velha

Vila Velha, Espírito Santo, Brazil
Hospital Vila da Serra

Nova Lima, Minas Gerais, Brazil
Santa Casa de Misericórdia de Passos

Passos, Minas Gerais, Brazil

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