New program aims to cut unnecessary antibiotics in ventilated kids

NCT ID NCT04987840

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a diagnostic stewardship program—a set of guidelines to help doctors decide when to order respiratory cultures—can safely reduce antibiotic use in critically ill children on ventilators. Researchers will track changes in how often cultures are taken and how many antibiotics are prescribed across 15 children's hospitals. The goal is to find a way to lower antibiotic overuse without harming patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could provide hospitals with a proven strategy to reduce unnecessary antibiotic use in children on ventilators, lowering the risk of antibiotic resistance.
What could go wrong: This is a very small, early-stage implementation study with only 15 hospitals. It focuses on changing doctor behavior, not testing a new drug, so results may not apply broadly or lead to immediate patient benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated tracheobronchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRACHEOBRONCHITIS VENTILATOR ASSOCIATED PNEUMONIA

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital and Medical Center Omaha

Omaha, Nebraska, 68114, United States
Children's Minnesota Hospital

Minneapolis, Minnesota, 55404, United States
Cleveland Clinic Children's Hospital

Cleveland, Ohio, 44106, United States
Dell Children's Medical Center

Austin, Texas, 78723, United States
Johns Hopkins Children's Center

Baltimore, Maryland, 21287, United States
Le Bonheur Children's Hospital

Memphis, Tennessee, 38103, United States
Monroe Carell Jr. Children's Hospital

Nashville, Tennessee, 37232, United States

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