Could kidney overdrive be undermining pain relief in sickle cell crises?
NCT ID NCT07246265
First seen Jan 04, 2026 · Last updated Jun 12, 2026 · Updated 30 times
Summary
This study looks at 100 adults with sickle cell disease who are in intensive care for severe pain crises and receiving morphine. Researchers want to see if faster kidney filtration (common in sickle cell patients) causes morphine to be cleared too quickly, leading to underdosing and poor pain control. By measuring kidney function and morphine levels, they aim to develop personalized dosing guidelines for better pain relief.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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CH Le Mans
NOT_YET_RECRUITINGLe Mans, 72000, France
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CHRU de Tours
RECRUITINGTours, France, 37044, France
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CHU d'Orléans
NOT_YET_RECRUITINGOrléans, 45067, France
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CHU de Nantes
NOT_YET_RECRUITINGNantes, 44093, France
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CHU de Rennes
NOT_YET_RECRUITINGRennes, France
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Henri-Mondor
NOT_YET_RECRUITINGCréteil, France
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