Could water pills be the key to protecting kidneys and hearts?

NCT ID NCT05732727

Recruiting now Disease control Sponsor: University Hospital, Tours Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and track outcomes like kidney failure, heart problems, and death. The goal is to see if this approach can reduce serious complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: diuretics (water pills)
What this could lead to: If successful, this could provide a clearer, more effective treatment plan for controlling blood pressure in people with chronic kidney disease, potentially reducing the risk of kidney failure, heart problems, and death.
What could go wrong: This is a large phase 3 trial, but it is still testing a specific treatment algorithm. The results may not apply to all patients, and there is always a chance the diuretic-based approach is no better than standard care.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE (CKD) UNCONTROLLED HYPERTENSION

Contacts and locations

Locations

AUB Santé foundation, Brest
RECRUITING

Brest, 29200, France
AUB Santé foundation, Lorient
RECRUITING

Lorient, 56100, France
Department of Nephrology, Bichat Hospital, AP-HP
RECRUITING

Paris, 75018, France
Department of Nephrology, Departemental Hospital of Vendée
RECRUITING

La Roche-sur-Yon, 85925, France
Department of Nephrology, European Hospital Georges Pompidou, AP-HP
ACTIVE_NOT_RECRUITING

Paris, 75015, France
Department of Nephrology, Hospital of Chalon-sur-Saône
RECRUITING

Chalon-sur-Saône, France
Department of Nephrology, Hospital of Chartres
RECRUITING

Chartres, 28630, France
Department of Nephrology, Hospital of Colmar
RECRUITING

Colmar, 68024, France
Department of Nephrology, Hospital of Haguenau
RECRUITING

Haguenau, 67500, France
Department of Nephrology, Hospital of Le Puy en Velay
RECRUITING

Le Puy-en-Velay, 43012, France
Department of Nephrology, Hospital of Orléans
RECRUITING

Orléans, 45067, France
Department of Nephrology, Hospital of Perpignan
RECRUITING

Perpignan, 66046, France
Department of Nephrology, Hospital of Roubaix
RECRUITING

Roubaix, 59100, France
Department of Nephrology, Hospital of Saint Malo
RECRUITING

St-Malo, 35400, France
Department of Nephrology, Hospital of Strasbourg
RECRUITING

Strasbourg, 67000, France
Department of Nephrology, Hospital of Valenciennes
RECRUITING

Valenciennes, 59322, France
Department of Nephrology, Necker Hospital, AP-HP
RECRUITING

Paris, 75015, France
Department of Nephrology, Regional Hospital of Metz
RECRUITING

Metz, 57085, France
Department of Nephrology, Régional Hospital of Mulhouse
RECRUITING

Mulhouse, 68100, France
Department of Nephrology, Tenon Hospital, AP-HP
ACTIVE_NOT_RECRUITING

Paris, 75020, France
Department of Nephrology, University Hospital of Angers
RECRUITING

Angers, 49933, France
Department of Nephrology, University Hospital of Bordeaux
RECRUITING

Bordeaux, 33000, France
Department of Nephrology, University Hospital of Brest
RECRUITING

Brest, 29200, France
Department of Nephrology, University Hospital of Clermont-Ferrand
RECRUITING

Clermont-Ferrand, 63001, France
Department of Nephrology, University Hospital of Grenoble
RECRUITING

Grenoble, 38043, France
Department of Nephrology, University Hospital of Lille
RECRUITING

Lille, 59000, France
Department of Nephrology, University Hospital of Limoges
RECRUITING

Limoges, 87042, France
Department of Nephrology, University Hospital of Lyon
RECRUITING

Lyon, 69003, France
Department of Nephrology, University Hospital of Marseille
RECRUITING

Marseille, 13005, France
Department of Nephrology, University Hospital of Nancy
RECRUITING

Vandœuvre-lès-Nancy, 54511, France
Department of Nephrology, University Hospital of Nantes
RECRUITING

Nantes, 44093, France
Department of Nephrology, University Hospital of Nîmes
RECRUITING

Nîmes, 30029, France
Department of Nephrology, University Hospital of Reims
RECRUITING

Reims, 51092, France
Department of Nephrology, University Hospital of Rennes
RECRUITING

Rennes, 35033, France
Department of Nephrology, University Hospital of Rouen
RECRUITING

Rouen, 76230, France
Department of Nephrology, University Hospital of Saint Etienne
RECRUITING

Saint-Etienne, 42270, France
Department of Nephrology, University Hospital of Tours
RECRUITING

Tours, 37044, France
ECHO Santé Association, Le Mans
RECRUITING

Le Mans, 72100, France
ECHO Santé Association, Nantes
RECRUITING

Nantes, 44402, France
ECHO Santé Association, Saint Herblain
ACTIVE_NOT_RECRUITING

Saint-Herblain, 44819, France

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