Could water pills be the key to protecting kidneys and hearts?
NCT ID NCT05732727
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial is testing whether a blood pressure treatment plan that focuses on diuretics (water pills) works better than usual care for people with moderate to severe chronic kidney disease and uncontrolled high blood pressure. The study will include 720 participants and track outcomes like kidney failure, heart problems, and death. The goal is to see if this approach can reduce serious complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
diuretics (water pills)
What this could lead to
If successful, this could provide a clearer, more effective treatment plan for controlling blood pressure in people with chronic kidney disease, potentially reducing the risk of kidney failure, heart problems, and death.
What could go wrong
This is a large phase 3 trial, but it is still testing a specific treatment algorithm. The results may not apply to all patients, and there is always a chance the diuretic-based approach is no better than standard care.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AUB Santé foundation, Brest
RECRUITINGBrest, 29200, France
Contact
Contact
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AUB Santé foundation, Lorient
RECRUITINGLorient, 56100, France
Contact
Contact
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Department of Nephrology, Bichat Hospital, AP-HP
RECRUITINGParis, 75018, France
Contact
Contact
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Department of Nephrology, Departemental Hospital of Vendée
RECRUITINGLa Roche-sur-Yon, 85925, France
Contact
Contact
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Department of Nephrology, European Hospital Georges Pompidou, AP-HP
ACTIVE_NOT_RECRUITINGParis, 75015, France
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Department of Nephrology, Hospital of Chalon-sur-Saône
RECRUITINGChalon-sur-Saône, France
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Contact
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Department of Nephrology, Hospital of Chartres
RECRUITINGChartres, 28630, France
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Department of Nephrology, Hospital of Colmar
RECRUITINGColmar, 68024, France
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Contact
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Department of Nephrology, Hospital of Haguenau
RECRUITINGHaguenau, 67500, France
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Department of Nephrology, Hospital of Le Puy en Velay
RECRUITINGLe Puy-en-Velay, 43012, France
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Contact
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Department of Nephrology, Hospital of Orléans
RECRUITINGOrléans, 45067, France
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Department of Nephrology, Hospital of Perpignan
RECRUITINGPerpignan, 66046, France
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Department of Nephrology, Hospital of Roubaix
RECRUITINGRoubaix, 59100, France
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Department of Nephrology, Hospital of Saint Malo
RECRUITINGSt-Malo, 35400, France
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Department of Nephrology, Hospital of Strasbourg
RECRUITINGStrasbourg, 67000, France
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Contact
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Department of Nephrology, Hospital of Valenciennes
RECRUITINGValenciennes, 59322, France
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Department of Nephrology, Necker Hospital, AP-HP
RECRUITINGParis, 75015, France
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Department of Nephrology, Regional Hospital of Metz
RECRUITINGMetz, 57085, France
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Department of Nephrology, Régional Hospital of Mulhouse
RECRUITINGMulhouse, 68100, France
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Contact
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Department of Nephrology, Tenon Hospital, AP-HP
ACTIVE_NOT_RECRUITINGParis, 75020, France
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Department of Nephrology, University Hospital of Angers
RECRUITINGAngers, 49933, France
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Contact
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Department of Nephrology, University Hospital of Bordeaux
RECRUITINGBordeaux, 33000, France
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Contact
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Department of Nephrology, University Hospital of Brest
RECRUITINGBrest, 29200, France
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Contact
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Department of Nephrology, University Hospital of Clermont-Ferrand
RECRUITINGClermont-Ferrand, 63001, France
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Contact
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Department of Nephrology, University Hospital of Grenoble
RECRUITINGGrenoble, 38043, France
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Department of Nephrology, University Hospital of Lille
RECRUITINGLille, 59000, France
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Contact
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Department of Nephrology, University Hospital of Limoges
RECRUITINGLimoges, 87042, France
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Contact
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Department of Nephrology, University Hospital of Lyon
RECRUITINGLyon, 69003, France
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Contact
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Department of Nephrology, University Hospital of Marseille
RECRUITINGMarseille, 13005, France
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Contact
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Department of Nephrology, University Hospital of Nancy
RECRUITINGVandœuvre-lès-Nancy, 54511, France
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Contact
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Department of Nephrology, University Hospital of Nantes
RECRUITINGNantes, 44093, France
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Contact
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Department of Nephrology, University Hospital of Nîmes
RECRUITINGNîmes, 30029, France
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Department of Nephrology, University Hospital of Reims
RECRUITINGReims, 51092, France
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Department of Nephrology, University Hospital of Rennes
RECRUITINGRennes, 35033, France
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Contact
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Department of Nephrology, University Hospital of Rouen
RECRUITINGRouen, 76230, France
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Department of Nephrology, University Hospital of Saint Etienne
RECRUITINGSaint-Etienne, 42270, France
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Department of Nephrology, University Hospital of Tours
RECRUITINGTours, 37044, France
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ECHO Santé Association, Le Mans
RECRUITINGLe Mans, 72100, France
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Contact
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ECHO Santé Association, Nantes
RECRUITINGNantes, 44402, France
Contact
Contact
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ECHO Santé Association, Saint Herblain
ACTIVE_NOT_RECRUITINGSaint-Herblain, 44819, France