Could a common antibiotic stop pneumonia from turning deadly?

NCT ID NCT06294600

Recruiting now Disease control Sponsor: Hellenic Institute for the Study of Sepsis Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving the antibiotic clarithromycin early, guided by a blood test (suPAR), can prevent pneumonia from worsening into sepsis. About 330 adults with community-acquired pneumonia will receive either clarithromycin or a placebo. The goal is to see if this approach improves symptoms, organ function, and immune markers within four days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clarithromycin
What this could lead to: If successful, this could provide a simple, early treatment to stop pneumonia from turning into sepsis, reducing hospital stays and deaths.
What could go wrong: This is a Phase 3 trial, but previous results were mixed. The benefit may be small or not apply to all patients, and clarithromycin can cause side effects like stomach upset or heart rhythm issues.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia pneumonia Sepsis infectious disease with sepsis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMMUNITY-ACQUIRED PNEUMONIA

Contacts and locations

Locations

1st Department of Internal Medicine - General Hospital of Athens "Sismanogleio-Amalia Fleming"
NOT_YET_RECRUITING

Athens, Greece, Greece
1st Department of Internal Medicine, AHEPA University General Hospital of Thessaloniki
RECRUITING

Athens, Greece, Greece
1st Department of Internal Medicine, EVANGELISMOS Athens General Hospital
RECRUITING

Athens, Greece, Greece
1st Department of Internal Medicine, G. GENNIMATAS Athens General Hospital
RECRUITING

Athens, Greece, Greece
1st Department of Internal Medicine, General University Hospital of Ioannina
RECRUITING

Athens, Greece, Greece
1st Department of Internal Medicine, KORGIALENEIO-BENAKEIO E.E.S. Athens General Hospital
RECRUITING

Athens, Greece, Greece
1st Department of Internal Medicine, THRIASIO General Hospital of Elefsis
RECRUITING

Athens, Greece, Greece
1st University Department of Pulmonary Medicine, SOTIRIA General Hospital of Chest Diseases of Athens
RECRUITING

Athens, Greece, Greece
2nd Department of Internal Medicine, Attikon University Hospital
RECRUITING

Athens, Greece, Greece
2nd Department of Internal Medicine, THRIASIO General Hospital of Elefsis
RECRUITING

Athens, Greece, Greece
2nd Department of Internal Medicine, TZANEIO Piraeus General Hospital
RECRUITING

Athens, Greece, Greece
2nd Department of Internal Medicine, University General Hospital of Alexandroupolis
RECRUITING

Athens, Greece, Greece
3rd Department of Internal Medicine - General State Hospital of Nikaia "Saint Panteleimon" - West Attica General Hospital
RECRUITING

Athens, Greece, Greece
3rd Department of Internal Medicine, General Hospital of Athens KORGIALENEIO- BENAKEIO E.E.S.
RECRUITING

Athens, Greece, Greece
3rd Department of Internal Medicine, PAPAGEORGIOU General Hospital of Thessaloniki
RECRUITING

Thessaloniki, Thessaloniki, 564 29, Greece
3rd University Department of Internal Medicine, SOTIRIA Athens General Hospital of Chest Diseases
RECRUITING

Athens, Greece, Greece
4th Department of Internal Medicine, Attikon University Hospital
RECRUITING

Athens, Greece, Greece
5th Pulmonary Department, SOTIRIA Athens General Hospital of Chest Diseases
RECRUITING

Athens, Athens, 115 27, Greece
6th Pulmonary Medicine Department, SOTIRIA General Hospital of Chest Diseases of Athens
RECRUITING

Athens, Greece, Greece
Department of Chest Medicine, EVANGELISMOS Athens General Hospital
RECRUITING

Athens, Greece, Greece
Department of Internal Medicine, Larissa University General Hospital
RECRUITING

Athens, Greece, Greece
Department of Internal Medicine, Patras University General Hospital
RECRUITING

Athens, Greece, Greece
Department of Pulmonary Medicine, General Hospital of Kerkira
RECRUITING

Athens, Greece, Greece
Emergency Department, TZANEIO Piraeus General Hospital
RECRUITING

Athens, Greece, Greece

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