Could a common antibiotic replace stronger drugs for pneumonia in seniors?
NCT ID NCT06229288
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial compares amoxicillin alone to amoxicillin/clavulanate for treating community-acquired pneumonia in adults aged 65 and older who are hospitalized but not in intensive care. The goal is to see if the narrower antibiotic works just as well, which could reduce side effects and slow antibiotic resistance. About 326 participants will be randomly assigned to one of the two treatments for 5 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Amoxicillin and amoxicillin/clavulanate
What this could lead to
If successful, this could show that a narrower antibiotic (amoxicillin alone) is just as effective as a broader one, reducing side effects and antibiotic resistance.
What could go wrong
This is a single trial with 326 participants, so results may not apply to all older adults. There is a risk that amoxicillin alone may not work as well in some cases.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Assistance Publique Hopitaux De Marseille
RECRUITINGMarseille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CH Perigueux
RECRUITINGPérigueux, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CH Saint-Nazaire
RECRUITINGSaint-Nazaire, France, 44600, France
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CH Saint-Nazaire
RECRUITINGSaint-Nazaire, France, 44600, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CHD Vendée
RECRUITINGLa Roche-sur-Yon, France
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CHD Vendée
RECRUITINGLa Roche-sur-Yon, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHRU - TOULOUSE Hôpital Purpan
RECRUITINGToulouse, France
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CHRU - TOULOUSE Hôpital Purpan
RECRUITINGToulouse, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHRU Brest
RECRUITINGBrest, France
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CHRU Brest
RECRUITINGBrest, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHRU TOULOUSE - Hôpital Rangueuil
RECRUITINGToulouse, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Angers
RECRUITINGAngers, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Avicenne AP-HP
RECRUITINGBobigny, France
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CHU Avicenne AP-HP
RECRUITINGBobigny, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Grenoble-Alpes
RECRUITINGLa Tronche, France
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CHU Grenoble-Alpes
RECRUITINGLa Tronche, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Nantes
RECRUITINGNantes, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Centre Hospitalier Bretagne Atlantique
RECRUITINGVannes, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chu Angers
RECRUITINGAngers, France
Contact Phone: •••-•••-•••• Email: •••••@•••••