Could a Two-Drug combo stop repeat heart attacks?

NCT ID NCT05457582

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to high-intensity statin therapy can prevent future cardiovascular events in people who have recently had a heart attack or unstable angina and underwent a stent procedure. About 1,200 participants receive either the PCSK9 inhibitor or a placebo, plus a statin, and are followed for outcomes like heart attack, stroke, or rehospitalization. The goal is to see if the combination therapy reduces these risks more than statins alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a PCSK9 inhibitor (alirocumab or tafolecimab) plus high-intensity statin (rosuvastatin)
What this could lead to
If successful, this could establish a new standard of care for preventing repeat heart attacks and strokes in high-risk patients.
What could go wrong
This is a single study, and results may not apply to all patients. Adding a PCSK9 inhibitor also increases cost and requires injections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Nanjing First Hospital

    Nanjing, Jiangsu, 210006, China

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