New study tests if delaying radiation improves brain tumor control
NCT ID NCT06649058
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether giving systemic therapy first, followed by focused radiation (stereotactic radiosurgery), can better control brain metastases. About 316 adults with brain metastases that are low-risk will receive standard cancer drugs, then some will get radiation to all or only growing tumors. The goal is to see if this sequence improves disease control and safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- systemic therapy (standard cancer drugs) and stereotactic radiosurgery (focused radiation)
- What this could lead to
- If successful, this could show that adding focused radiation after initial drug therapy improves control of brain metastases and delays disease progression.
- What could go wrong
- This is a mid-stage trial with 316 participants, so results are not yet proven. The benefit may be small or limited to certain patients, and radiation carries risks like brain swelling or damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BRAIN METASTASES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a 3D camera make brain radiation safer and more precise?
- Pinpoint radiation may spare the brain in lung cancer that spreads
- Spinal fluid DNA test could personalize brain cancer therapy
- Focused radiation doses put to the test for large brain tumors
- Brain scan breakthrough: amino acid PET may solve a tricky diagnosis dilemma
- Spared brain region may shield memory during whole brain radiation