M.d. Anderson Cancer Center

This study tested whether adding a targeted drug called inotuzumab ozogamicin to a stem cell transplant regimen could better control leukemia and lymphoma. The drug is designed to seek out and kill cancer cells that have a specific marker (CD22). Researchers enrolled 15 patients …

This early-phase trial tested the safety and initial effectiveness of a new immunotherapy drug (BMS-986218), given alone or with another immunotherapy drug (nivolumab), alongside targeted radiation therapy. It was for adults with advanced solid cancers that had spread to other pa…

This early-stage study tested a new treatment for children and young adults whose solid tumors had returned or stopped responding to standard therapies. Researchers gave patients a combination of chemotherapy drugs followed by immune cells (NK cells) donated from umbilical cord b…

This study tested a combination of two drugs, futibatinib and pembrolizumab, for people with a specific type of advanced endometrial (uterine) cancer that had spread and was not responding well to standard chemotherapy. The goal was to see if this new combination could shrink tum…

This study aimed to see if adding an experimental drug called magrolimab to standard cancer treatments could help control advanced head and neck cancer that had returned or spread. It was designed for adults whose cancer had progressed despite prior therapy. The trial was termina…

This study tested if giving patients back their own collected immune cells after radiation and chemotherapy could safely help rebuild their immune system. It focused on adults with lung or esophageal cancer. The goal was to see if this approach could improve immune cell counts an…

This study tested how well two chemotherapy drugs, venetoclax and decitabine, work together to control aggressive blood cancers. It was for older adults newly diagnosed with acute myeloid leukemia (AML) or people whose AML or high-risk myelodysplastic syndrome (MDS) had returned …

This study tested a two-drug combination for people with advanced kidney cancer (clear cell RCC) that had spread and worsened after they received standard treatments, including immunotherapy. The goal was to see if adding a pill called sitravatinib to an immunotherapy drug (nivol…

This study tested a new, experimental drug called APX005M, which was injected directly into tumors. It was combined with an approved immunotherapy drug (pembrolizumab) given by IV. The main goals were to find a safe dose and see if the combination could help control advanced mela…

This early-phase study aimed to see if a drug called belantamab mafodotin (Blenrep) could help prevent multiple myeloma from returning in patients who had already relapsed and received a salvage stem cell transplant. Researchers wanted to test the safety of giving this drug as on…

This study tested whether using real-time MRI scans to guide radiation therapy could be a safe and effective way to treat lung tumors located near critical organs. It compared this new MRI-guided approach to the standard CT-guided method. The goal was to see if the MRI technique …

This early-stage study tested the safety of a drug called itacitinib for patients who developed a serious lung scarring condition (bronchiolitis obliterans) after a donor stem cell transplant. The trial aimed to see if the drug could help control this complication and improve pat…

This study tested whether adding a targeted drug called alpelisib to a chemotherapy drug (nab-paclitaxel) could help shrink tumors before surgery. It was for people with a specific, hard-to-treat type of breast cancer (triple-negative) that had not responded well to a common firs…

This study tested whether a less invasive surgery could safely treat women with early-stage, low-risk cervical cancer. Researchers compared this conservative approach to traditional radical surgery to see if it reduced side effects while still controlling the cancer. The trial en…

This study aimed to see if a drug called repotrectinib, given with or without another drug called fulvestrant, could help control metastatic lobular breast cancer in people whose cancer had progressed after standard hormone-based treatments. It was a Phase 2 trial that enrolled o…

This early-phase study tested a combination of two drugs, bintrafusp alfa and pimasertib, for patients with cancer that had spread to the brain (brain metastases). The goal was to find a safe dose and see if the combination could help control the brain tumors and help patients li…

This study tested whether the drug ofatumumab could control chronic lymphocytic leukemia or small lymphocytic lymphoma that remained after patients completed chemotherapy. Participants received up to 20 infusions over two years to target residual cancer cells. The trial was termi…

This study tested if adding a new drug called pirtobrutinib to an existing treatment (venetoclax) could help eliminate the last traces of cancer in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. It was for adults who had already been on venetoclax for a…

This study tested combinations of several cancer drugs for patients with advanced or inflammatory breast cancer that had spread or was locally advanced. The main goals were to find a safe dose and to see if the treatment could completely eliminate cancer from the breast and lymph…

This early-stage trial aimed to test the safety of a new drug, YL-13027, when given alongside two standard chemotherapy drugs (gemcitabine and nab-paclitaxel) to patients with metastatic pancreatic cancer that had stopped responding to prior treatment. The study was designed to f…

This study tested whether adding a new drug called ABL001 to standard CML medications could help patients achieve a deeper remission. It was for patients who still had very low levels of detectable leukemia despite being on long-term treatment. The goal was to see if the two-drug…

This study aimed to see if removing liver tumors through surgery, in addition to standard chemotherapy, helps patients with colorectal cancer that has spread to both the liver and lungs. It compared two groups: one received surgery plus chemo, and the other received chemo alone. …

This study tested whether a drug called erdafitinib could help control advanced prostate cancer that had stopped responding to standard hormone treatments and spread to the bones. It involved 11 men and aimed to see if the drug could slow cancer growth and reduce bone-related mar…

This early-phase study aimed to find the safest and most effective dose of the drug pomalidomide for patients with Waldenstrom macroglobulinemia, a rare blood cancer that had returned or stopped responding to prior treatments. The trial enrolled 15 patients to carefully monitor s…

This study tested whether the drug ponatinib could control an aggressive form of chronic myeloid leukemia when used as the first treatment. It involved 51 adults with newly diagnosed advanced leukemia. The trial was terminated early, and the drug carries a serious risk of causing…

This study tested a new drug called ADCT-602 for adults with a fast-growing blood cancer (B-cell acute lymphoblastic leukemia) that has come back or stopped responding to standard treatments. The main goals were to find a safe and effective dose and to see if the drug could help …

This study tested a three-part treatment for advanced head and neck cancer that has come back or spread. Doctors injected a nanoparticle called NBTXR3 directly into a tumor, then activated it with a short, precise course of radiation. Patients also received the immunotherapy drug…

This study tested an oral medication called poziotinib for people with advanced non-small cell lung cancer that had specific mutations in the EGFR or HER2 genes. The goal was to see if the drug could shrink tumors by blocking enzymes that help cancer cells grow. The trial involve…

This study tested whether a two-drug maintenance therapy could help control multiple myeloma that has returned after a patient's second stem cell transplant. The treatment combined an antibody drug (daratumumab) with a chemotherapy pill (pomalidomide), given for up to three years…

This study tested whether combining two drugs, apalutamide and abiraterone acetate, could better control advanced prostate cancer that had spread and stopped responding to standard hormone therapy. It aimed to see if this combination could slow the cancer's growth in men whose tu…

This study tested whether a combination of two immunotherapy drugs, nivolumab and ipilimumab, could help control a rare and aggressive type of kidney cancer called renal medullary carcinoma. It involved a small group of patients with advanced disease to see if the treatment could…

This study tested whether combining two existing drugs, copanlisib and fulvestrant, could help control advanced endometrial or ovarian cancers that are hormone-sensitive and have specific genetic changes. The trial aimed to find a safe dose and see if the combination could shrink…

This study tested a combination of two chemotherapy drugs, venetoclax and azacitidine, for people with high-risk myelodysplastic syndromes (MDS) or related blood cancers. It aimed to find a safe dose and see if the treatment could control the disease, especially for patients whos…

This study tested a combination of two drugs, omacetaxine and venetoclax, for adults with acute myeloid leukemia or myelodysplastic syndrome that has returned or stopped responding to treatment, and who have a specific genetic change called RUNX1. The goal was to find the safest,…

This study tested whether combining two drugs, CB-103 and venetoclax, could help control a hard-to-treat type of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL) in adolescents and young adults. The trial was for patients aged 12 to 60 whose cancer had returned or …

This study tested whether two common nutritional supplements could help treat a serious liver side effect caused by certain leukemia medications. It involved adults with acute lymphoblastic leukemia who developed high liver enzymes during treatment. The goal was to see if taking …

This study aims to create a detailed database of penile cancer patients to better understand how this cancer develops and responds to treatment over time. Researchers will collect information from about 500 patients about their diagnosis, treatments, and outcomes every six months…

This study tested whether two new types of PET scans could better detect tumors in people with advanced colorectal cancer that had spread. Six participants received two different radioactive tracers and underwent scans to see if these new methods were more accurate than standard …

This study tested whether a simple finger-sensor device could be used to check blood vessel health in children and young adults getting stem cell transplants. The goal was to see if the test was practical to perform on these patients. The study was terminated and did not test a t…