M.d. Anderson Cancer Center

This study is testing how well the Gardasil 9 vaccine works to prevent HPV infection in cancer patients who have received a donor stem cell transplant. Researchers are giving the vaccine to 48 adult patients 6-12 months after their transplant to see if their immune systems can bu…

This study is testing a two-drug combination to control chronic myelomonocytic leukemia and related blood cancers. It aims to find the safest, most effective dose and see how well the treatment works. The treatment pairs a targeted drug that seeks out cancer cells with a standard…

This study is testing a combination of three oral chemotherapy drugs for people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who haven't had prior treatment. The first phase aims to find the safest dose, and the second phase measures how…

This small, early-stage study is testing whether the immunotherapy drug pembrolizumab can help control smoldering multiple myeloma, a slow-growing blood cancer that has a high risk of turning into active disease. The drug works by helping the body's own immune system recognize an…

This study is testing whether a combination of three drugs works better to control an aggressive form of breast cancer that has spread or returned. The drugs work together: one boosts the immune system, one blocks cancer cell growth signals, and one is a chemotherapy. The trial i…

This study is testing a two-part drug combination to control multiple myeloma, a blood cancer, in patients whose disease has come back or stopped responding to prior treatments. It combines an immunotherapy drug that helps the immune system attack cancer with other drugs that blo…

This study is testing if taking the drug sunitinib before surgery helps control metastatic kidney cancer. Fifty patients with kidney cancer that has spread and who are eligible for tumor-removing surgery will take sunitinib for four weeks, have surgery, then continue the drug. Re…

This study aims to find out if standard chemotherapy drugs can slow the growth of a rare abdominal cancer called appendiceal adenocarcinoma. Thirty patients who cannot have complete surgery will either receive chemotherapy first or be observed first, with their tumor growth measu…

This study is testing a more personalized way to deliver radiation treatment for advanced liver cancer that cannot be removed by surgery. Doctors aim to give a stronger, more precise dose of radiation directly to the tumor while trying to better protect the healthy parts of the l…

This study is testing new drug combinations for people with pancreatic cancer that has not spread widely. It compares these experimental treatments to standard chemotherapy. The goal is to see if the new approaches can better shrink tumors before surgery or control the disease fo…

This early-stage study is testing a combination of four drugs for people with a specific type of advanced lung cancer (ALK-positive). The main goals are to find the safest dose of the new drug, ensartinib, when given with three other cancer drugs, and to see if this combination h…

This study compares two counseling approaches combined with nicotine patches to help people quit smoking. Researchers are testing whether a therapy focused on increasing positive activities works better than standard counseling for certain smokers. The trial involves 85 participa…

This study is testing whether adding the drug sorafenib to two standard chemotherapy drugs (carboplatin and paclitaxel) can better control advanced head and neck cancer that has spread or returned. It aims to see if this combination can slow cancer growth and extend the time pati…

This early-stage trial is testing whether adding specially treated immune cells, called 'veto cells,' can help patients with blood cancers or bone marrow disorders after a stem cell transplant from a half-matched donor. The goal is to help the donor's cells grow and work in the p…

This study is testing whether combining two drugs, selumetinib and olaparib, can help control advanced or returning solid tumors. The first phase aims to find the safest, highest dose of the combination. The second phase will see if that dose helps patients with specific cancers,…

This study is testing a cancer drug called acalabrutinib for people with mantle cell lymphoma who had to stop a similar drug, ibrutinib, because of severe side effects. The goal is to see if acalabrutinib can control the cancer while being easier for patients to tolerate. Researc…

This early-stage study is testing the safety and best doses of a three-drug combination (daratumumab, ixazomib, and dexamethasone) for people with AL amyloidosis, a rare disease where abnormal proteins damage organs. The goal is to see if this combination can control the disease …

This early-stage trial aims to find the safest and most effective doses of new drug combinations for people with advanced cancer that has not responded to standard treatments. Researchers are testing two core drugs (bevacizumab and temsirolimus) paired with one of three other can…

This study is testing whether specific genetic markers in a patient's tumor can predict if they will respond well to immunotherapy drugs. It is for people with advanced bladder cancer that has spread and has stopped responding to standard chemotherapy. Participants receive two im…

This early-stage study aims to find the safest and most effective dose of a new drug, ADI-PEG20, when combined with two existing chemotherapy drugs (carboplatin and cabazitaxel). It is for men with a fast-growing, hard-to-treat form of advanced prostate cancer. The goal is to con…

This early-stage study aims to find the safest and most effective dose of two oral medications, ceritinib and everolimus, when used together. It involves adults with advanced solid tumors or a specific type of lung cancer (ALK-positive non-small cell lung cancer) that has spread …

This study is testing whether adding an immunotherapy drug called durvalumab to standard chemotherapy is safe and effective for treating advanced ovarian, fallopian tube, or primary peritoneal cancer. It involves 18 patients who have not had prior treatment. The goal is to see if…

This is an early safety study testing a new type of intravenous drug called EphA2 siRNA in patients with advanced solid tumors that have spread or returned after treatment. The drug is designed to slow cancer growth by 'silencing' a specific gene that helps tumors grow. The main …

This was a very early study designed to test the safety and side effects of an experimental drug called MT-0169 in patients with acute leukemia. It was intended for people whose cancer had come back, did not respond to standard treatments, or had small amounts of leftover disease…

This study is testing a combination of four drugs as the first treatment for patients with a specific genetic type of chronic lymphocytic leukemia (CLL). The goal is to see if using these drugs together—a targeted therapy, two chemotherapy drugs, and an immunotherapy—is more effe…

This early-stage study aims to find the highest safe dose of three cancer drugs—gemcitabine, doxorubicin, and bortezomib—when given together. It is for people with advanced solid tumors or urethral cancer that cannot be removed by surgery and have not responded to standard treatm…

This study aimed to test if an oral drug called ASTX727, given alone or with an infusion of donor immune cells, could help control blood cancers like leukemia after a stem cell transplant. It was designed for adults who had received a transplant but were at high risk of their can…

This study is testing whether the drug cetuximab can help control advanced or spreading chordoma, a rare type of bone cancer. It involves adults whose cancer cannot be removed by surgery or has spread. The main goal is to see if the drug shrinks tumors and how long patients live …

This study is testing if a fecal microbiota transplant (FMT) can help immunotherapy drugs work for people with advanced colorectal cancer who previously did not respond to them. The FMT uses processed stool from patients who did respond to the treatment, with the goal of changing…

This study aimed to test whether combining two drugs could help control advanced blood cancers that have specific genetic changes and have stopped responding to standard treatments. The trial was designed for adults with myelodysplastic syndromes or related conditions who had alr…

This study is testing whether adding the drug rituximab to standard radiation therapy works better than radiation alone for people with early-stage, slow-growing follicular lymphoma. Rituximab is an immunotherapy drug that helps the immune system attack cancer cells. The main goa…

This study is testing if adding a drug called durvalumab (an immunotherapy) to standard chemotherapy works better than chemotherapy alone for bladder cancer that has spread to nearby lymph nodes. The goal is to shrink the cancer more effectively before surgery. Patients will be r…

This study is testing whether two drugs, lenvatinib and pembrolizumab, work better together for people with advanced anaplastic thyroid cancer that cannot be removed by surgery or has spread. Lenvatinib aims to block tumor growth, while pembrolizumab helps the body's immune syste…

This early-stage study is testing a combination of two drugs, niraparib (a pill) and copanlisib (an IV infusion), for women whose ovarian, endometrial, or related cancers have returned after prior treatment. The main goals are to find the safest dose of this combination and to le…

This early-stage study is testing the safety of an experimental drug called UGN-201 in bladder cancer patients who are scheduled to have their bladder surgically removed. The research involves 10 participants and aims to understand if UGN-201 is safe to give before surgery and wh…

This study is testing if precisely targeted radiation can control kidney cancer that has spread to only a few other body sites. The goal is to see if this approach can delay or avoid the need for stronger, body-wide drug treatments. It involves 123 adults with a limited number of…

This early-stage trial is testing whether adding the immunotherapy drug pembrolizumab after radiation therapy is safe and tolerable for patients with malignant pleural mesothelioma who still have both lungs. The study aims to see if this combination helps the immune system better…

This early-stage trial is testing the safety and best dose of a new drug, adagrasib, when combined with two existing cancer drugs (cetuximab and irinotecan). It is for adults with advanced colorectal cancer that has a specific genetic change called KRAS G12C and has stopped respo…

This study is testing whether adding the drug hydroxychloroquine to standard chemotherapy (gemcitabine and docetaxel) helps control recurrent osteosarcoma, a type of bone cancer that has returned or stopped responding to treatment. It aims to find the safest dose and see if this …

This small, early-stage study is testing whether combining an immunotherapy drug (pembrolizumab) with chemotherapy and radiation can help control a type of stomach cancer that cannot be removed by surgery. The goal is to see if this three-part approach is safe and can shrink or e…

This early-stage trial is testing a new way to give an immunotherapy drug called nivolumab to patients with melanoma or lung cancer that has spread to the membranes surrounding the brain and spinal cord. The goal is to see if giving the drug directly into the spinal fluid, along …

This study is testing whether the drug bevacizumab (Avastin) can help control ovarian, fallopian tube, or primary peritoneal cancer that was discovered during a second surgery after initial treatment. The research involves 35 participants who have completed standard chemotherapy …

This early-stage trial is testing whether giving the drug AL101 before standard surgery can help control adenoid cystic carcinoma, a rare type of cancer. The study involves 14 patients whose tumors have a specific genetic marker called NOTCH activation. Researchers will check if …

This study is testing whether choosing cancer drugs based on the unique genetic changes found in a patient's tumor is more effective at controlling the disease than standard treatment. It involves over 1,300 people with metastatic cancer, meaning cancer that has spread. Patients …

This study is testing whether taking a daily pill called ibrutinib for up to five years can delay the progression of a slow-growing, high-risk form of mantle cell lymphoma in patients who have not yet received any treatment. The goal is to see if this long-term medication can kee…

This study compares two types of radiation therapy for patients with 4 to 15 brain metastases from cancers other than melanoma. One method targets tumors precisely with a single high dose, while the other treats the entire brain with lower doses over two weeks. Researchers want t…

This study tested whether adding the drug sunitinib to standard hormone therapy could better shrink or control prostate tumors in men scheduled for prostate removal surgery. It involved 64 men with high-risk, localized prostate cancer. The goal was to see if this combination trea…

This study is testing whether two oral medications, venetoclax and acalabrutinib, can help control mantle cell lymphoma that has returned or didn't respond to previous treatments. The trial involves 32 adults who have already tried at least one other therapy. Researchers want to …

This study is for people with advanced non-small cell lung cancer that has a specific genetic change (EGFR mutation). It tests if taking the targeted drug osimertinib for 6-12 weeks, then adding focused radiation therapy or surgery to remaining tumors, works better at keeping the…

This study aimed to test the safety and effectiveness of combining two drugs, TTI-101 and pembrolizumab, for adults with advanced head and neck cancer that had returned or spread. The goal was to see if this combination could help control the cancer better than standard treatment…

This study is testing whether two drugs, isatuximab and lenalidomide, can delay or prevent high-risk smoldering multiple myeloma from progressing to active, symptomatic cancer. It involves 61 adults whose condition shows signs it is likely to worsen soon. Participants receive the…

This study is testing whether combining two drugs, evolocumab and nivolumab, can help control advanced kidney cancer that has stopped responding to standard immunotherapy or other targeted drugs. It will involve about 10 adults with metastatic kidney cancer to see if the combinat…

This study is testing a personalized treatment for people with metastatic melanoma, a serious form of skin cancer that has spread. Doctors take a patient's own immune cells, grow them in large numbers in a lab, and then infuse them back into the patient to attack the cancer. The …

This study is testing a highly focused, single-dose radiation treatment for people with melanoma that has spread to more than three spots in the brain. The main goals are to see if this treatment can control the brain tumors and, importantly, if it causes less memory and thinking…

This study is testing whether giving immune-boosting drugs, with or without radiation, before surgery can help shrink tumors and improve outcomes for patients with two specific types of rare soft tissue cancers. The goal is to see if this pre-surgery treatment makes the cancer ea…

This early-stage study is testing whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer that has spread. Researchers will enroll 19 patients who haven't had previous treatment for their …

This study tests whether a 6-month personalized lifestyle program can help improve liver health in people with early signs of liver disease. Participants receive guidance on diet, exercise, alcohol use, and medication adherence through text messages and support. The goal is to se…

This study aims to find out if a newer type of radiation called proton beam therapy is better than standard photon therapy for treating throat cancer. It will compare how well each treatment controls the cancer and, importantly, which one causes fewer severe side effects. About 4…

This trial is testing if adding targeted radiation or surgery to standard drug therapy is better at controlling cancer that has spread to only a few places in the body. It will compare two groups of patients: one gets the extra local treatment right away, and the other gets drug …

This study is testing if a drug called vemurafenib can shrink thyroid tumors before surgery in patients with advanced cancer. The drug targets a specific genetic mutation found in the cancer cells. Researchers will measure changes in tumor size and certain biomarkers after 56 day…

This study is testing if adding a freezing treatment called cryoablation to standard immunotherapy helps patients whose cancer has spread. Researchers will freeze one tumor to see if it helps the body's immune system better attack other cancer spots. The trial includes 15 patient…

This early-stage study is testing the safety and best dose of a drug called palbociclib, given alone and in combination with other medications, for adults with acute leukemia that has come back or hasn't responded to previous treatments. The main goal is to find out what side eff…

This study is testing whether adding Juice Plus+ nutritional supplements to the diet helps ovarian cancer patients in remission have better outcomes compared to patients who only receive dietary counseling. About 75 patients will be randomly assigned to either take the supplement…

This study is testing a shorter, more intense schedule of proton beam radiation for men with early-stage prostate cancer that hasn't spread. The main goal is to see if this approach effectively controls the cancer while causing fewer long-term side effects, particularly to the di…

This study is testing whether a combination of two immunotherapy drugs, atezolizumab and bevacizumab, can help control several rare types of advanced solid tumors. The trial is for adults whose cancer has spread or returned after other treatments. The goal is to see if this drug …

This early-stage study is testing the safety and best dose of a two-part treatment for advanced bile duct cancer that has spread. Patients receive a short, intense course of radiation to one tumor, followed by an immunotherapy drug designed to help the immune system attack the ca…

This study tested a combination of four chemotherapy drugs (5-FU, leucovorin, gemcitabine, and cisplatin) in patients with advanced adenocarcinomas of the bladder, urethra, or a related structure called the urachal remnant. The main goals were to see how well the drug combo could…

This study aimed to test if the drug glofitamab could prevent cancer from returning in patients with large B-cell lymphoma. It was designed for people who had completed standard first treatment successfully but still had tiny amounts of cancer cells detectable in their blood. The…

This study is testing if adding a targeted drug called panitumumab to standard chemotherapy works better than chemotherapy alone before surgery for a fast-growing, hard-to-treat type of breast cancer. It aims to see which combination shrinks the tumor more effectively, potentiall…

This study is testing whether using simple devices at home to check for early signs of dehydration can help patients with head and neck cancer avoid trips to the emergency room or hospital. About 427 patients are comparing standard care to using a special monitoring system called…

This study is testing whether using two treatments together works better than one to control cancer that has spread to the spine and is at risk of pressing on the spinal cord. Doctors combine a heat treatment (thermal ablation) that destroys tumor cells with a very precise, high-…

This study is testing a four-drug combination given to patients before surgery for pancreatic cancer that can be removed. The treatment includes two standard chemotherapy drugs and two newer immunotherapy drugs designed to help the body's immune system fight the cancer. The main …

This study tested a two-part drug treatment for people with stage IIIB or IIIC melanoma that has a specific genetic change (BRAF V600 mutation). Patients took the drugs dabrafenib and trametinib for 8 weeks before surgery to try to shrink the tumor, then continued the drugs for a…

This study is testing a multi-step treatment plan for adults with a specific, aggressive form of leukemia (ALL) that has come back or hasn't responded to prior therapy. The plan combines lower-intensity chemotherapy with two targeted drugs, ponatinib and blinatumomab, to attack t…

This is an early-stage study to find the safest dose of a new drug called tegavivint for adults with leukemia that has come back or stopped responding to standard treatments. The drug aims to block cancer cell growth, and researchers are testing it alone and with another drug, de…

This study is testing whether combining a drug that helps the immune system fight cancer (atezolizumab) with different chemotherapy drugs can help people with aggressive forms of thyroid cancer that have spread or cannot be removed by surgery. The goal is to see if this combinati…

This study is testing whether adding a drug called ribociclib to a two-drug combination (everolimus and letrozole) works better for women with advanced or returning endometrial cancer. The trial will enroll 90 participants to see if the three-drug combo helps control the cancer l…

This early-stage trial is testing a new combination of three drugs—dasatinib, temsirolimus, and cyclophosphamide—to treat advanced solid tumors that have come back or stopped responding to other treatments. The main goal is to find the safest dose and understand the side effects.…

This study is testing a special counseling program combined with nicotine patches to help people who smoke and have depression quit. It compares two approaches: one adds mood management therapy, while the other adds general health education. The goal is to see which method is bet…

This study is testing whether a breathing exercise device can help head and neck cancer survivors who have had radiation therapy. The device strengthens muscles used for coughing and swallowing, which may reduce the risk of pneumonia caused by accidentally inhaling saliva. About …

This study is testing whether adding a special prebiotic-rich diet to standard immunotherapy can help control advanced melanoma that has stopped responding to previous immunotherapy. It involves a small group of patients who will follow the diet while receiving the drugs ipilimum…

This study is testing a combination of three drugs given before surgery for patients with a very aggressive type of thyroid cancer that has a specific genetic change (BRAF V600E mutation). The goal is to shrink the tumor and make it easier to remove completely during surgery, whi…

This study is testing a specialized radiation system to see if it can safely and effectively treat cancer that has spread to the spine. The goal is to control tumor growth and relieve pain. Researchers will use a special CT scanner in the same room as the radiation machine to aim…

This study compares two radiation schedules given after prostate cancer surgery. It tests whether a shorter, more intense 4.5-week course works as well as the standard 7-week course at keeping cancer from returning. Researchers will track side effects and quality of life for up t…

This study is testing two different combinations of three drugs to see if they are safe and effective for people with advanced melanoma that has a specific genetic change (BRAF mutation) and has spread or cannot be removed by surgery. The goal is to control the cancer by using an…

This study aimed to test if a drug called TTI-101 could reduce the size of head and neck cancers before patients had standard surgery. The trial planned to give the drug for a short period before the planned operation to see if it made the tumors easier to remove. However, the st…

This study compares two drugs, infliximab and vedolizumab, to treat severe colon inflammation and diarrhea caused by cancer immunotherapy drugs. The trial involves 47 patients with melanoma, lung cancer, or urinary cancers who developed these side effects. Researchers aim to find…

This study compares two radiation therapy methods for treating esophageal cancer: proton beam therapy (a newer, more precise method) and standard intensity-modulated radiation therapy. Researchers want to see if the newer proton therapy helps patients live longer without their ca…

This study is testing whether a shorter, 3-week radiation schedule is as effective as the standard 5-week schedule for preventing breast cancer from returning in the lymph nodes. It will also closely compare side effects, especially arm swelling (lymphedema), between the two grou…

This study is testing whether adding two drugs, venetoclax and azacitidine, after a stem cell transplant can help prevent high-risk leukemia from returning. It is for adults aged 18-75 with certain types of acute leukemia who have already had a transplant. The goal is to see if t…

This study is testing a new combination of three drugs for advanced bladder cancer that has spread or cannot be surgically removed. The first part aims to find the safest and most effective doses. The second part will see how well the chosen dose combination works to shrink tumor…

This study is testing whether supervised exercise before surgery can improve physical fitness in children and young adults with bone cancer. Researchers want to see if regular exercise during chemotherapy is practical and might help treatments work better. They're comparing super…

This study tested a two-drug combination (bortezomib and rituximab) as a first treatment for people with Waldenstrom's macroglobulinemia, a rare blood cancer. The main goals were to see if the treatment could control the disease and safely collect patients' own stem cells. These …

This study is testing if a drug called elotuzumab can help control myelofibrosis, a rare blood cancer that causes bone marrow scarring. The trial will involve about 15 adults with a specific genetic change (JAK2 mutation) who are not candidates for standard JAK inhibitor therapy.…

This study is testing whether combining a targeted form of radiation therapy with an immunotherapy drug (pembrolizumab) is safe and more effective than the drug alone for patients with advanced non-small cell lung cancer that has spread. The goal is to see if the radiation helps …

This study is testing whether adding two drugs (abiraterone acetate and prednisone) to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has returned after surgery or radiation. The goal is to keep PSA levels low for longer after the 8…

This study is testing whether two drugs, panitumumab and trametinib, can help control advanced colorectal cancer that has stopped responding to a previous, similar type of treatment. It involves 59 patients whose cancer has spread and who have specific genetic markers in their bl…

This early-phase trial is testing a combination of two drugs, avelumab and M6620, for people with advanced solid tumors that have spread or cannot be removed by surgery. The treatment is specifically for cancers with flaws in certain genes responsible for fixing DNA damage inside…

This study is testing a targeted drug called inotuzumab ozogamicin for adults with B-cell acute lymphoblastic leukemia (ALL) who are in remission but still have tiny amounts of cancer cells detectable by sensitive tests. The drug is designed to seek out and destroy these remainin…

This study is testing whether adding a new drug called ixazomib to two standard chemotherapy drugs works better for controlling an aggressive type of kidney cancer that has spread. It is for patients aged 12 and older whose cancer has progressed after other treatments and who hav…

This study is testing whether special imaging software can help doctors more accurately target and destroy liver tumors during a procedure called ablation. Patients with up to three liver tumors were randomly assigned to receive either the standard ablation procedure or the stand…

This study is testing whether a combination of two drugs, regorafenib and lorigerlimab, can clear tiny traces of cancer left in the blood after standard treatment for colorectal cancer. The goal is to see if this treatment can prevent the cancer from coming back in patients who s…

This study is testing whether combining two drugs, niraparib and dostarlimab, can help control recurrent small cell lung cancer and other aggressive neuroendocrine cancers. It is for adults whose cancer has returned after at least one prior treatment. The goal is to see if this c…

This study is testing whether a combination of two drugs, pemetrexed and avelumab, can help control advanced bladder cancer that has spread and has a specific genetic feature (MTAP-deficient). The trial is for people whose cancer has worsened after prior treatment. Researchers wa…

This study is testing a new treatment approach for patients with stomach or gastroesophageal cancer that can be surgically removed. It combines two immunotherapy drugs (nivolumab and ipilimumab) with chemotherapy and radiation before surgery, aiming to shrink the tumor and help t…

This early study is testing a two-part treatment for advanced non-small cell lung cancer with a specific genetic change (ALK). First, patients take a targeted drug (brigatinib) to shrink tumors. Then, they receive focused radiation or surgery to try to eliminate any remaining can…

This study is testing whether combining two drugs, dasatinib and venetoclax, can better control early-stage chronic myeloid leukemia (CML) than one drug alone. It will involve about 155 adults newly diagnosed with this type of blood cancer. The main goal is to see if the combinat…

This study tested whether the drug brentuximab vedotin could help control three types of CD30-positive skin lymphomas in patients whose disease had come back or did not respond to prior treatments. The drug is designed to find and enter cancer cells with a specific marker (CD30) …

This study is comparing two standard ways to treat small lung tumors: a minimally invasive procedure that uses microwave energy to heat and destroy the tumor, and a small surgery to cut it out. Researchers want to see which method is safer, more effective at keeping the cancer fr…

This study is testing whether a comprehensive lifestyle program can improve outcomes for people with stage II or III breast cancer who are undergoing radiation therapy. The program includes dietary coaching, exercise, stress management, and social support. Researchers want to see…

This study compares two different radiation therapy methods for patients whose head and neck cancer has returned and cannot be removed by surgery. One method delivers high-precision radiation in just 5 sessions, while the other uses a more standard approach over 6-7 weeks. The ma…

This study is testing if adding the drug olaparib after standard chemotherapy helps control a fast-growing, hard-to-treat form of prostate cancer. About 96 men with advanced, aggressive prostate cancer that has spread will receive chemotherapy, then some will receive olaparib pil…

This study aims to find out if one of two FDA-approved quit-smoking medications works better for people based on their brain activity and how they process emotions. About 200 adult smokers will receive counseling and be randomly assigned to take either varenicline (Chantix) or us…

This study is testing if a single, high-precision dose of radiation can safely control tumors that are pressing on the spinal cord in patients who cannot have surgery. The goal is to see if this one-time treatment can stop tumor growth and prevent paralysis, replacing the usual m…

This small, early-stage study is testing if adding a bone drug (zoledronic acid) to standard chemotherapy (paclitaxel and bevacizumab) helps control recurrent ovarian cancer that has stopped responding to platinum drugs. It will involve about 14 women to see if the three-drug com…

This study is testing whether giving two immunotherapy drugs before surgery can help people with operable liver cancer. The drugs, atezolizumab and bevacizumab, aim to help the body's immune system attack the cancer and cut off its blood supply. Researchers hope this pre-surgery …

This study is testing whether combining two existing drugs, lenalidomide and rituximab, can help control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is for adults who are either newly diagnosed and not candidates for standard chemo, or who have had …

This study is testing whether a brief online sleep program works better before or after getting advice on physical activity to help people become more active. It involves 28 overweight or obese African American adults who are currently sedentary and get less than 6 hours of sleep…

This study is for people with a type of breast cancer (HER2-negative) that did not completely disappear after standard chemotherapy before surgery. It tests whether adding a drug called ixabepilone after surgery helps control the cancer better than standard follow-up care alone. …

This study compares two existing drugs, cabozantinib and sunitinib, to see which is safer and more effective at controlling advanced kidney cancer that has spread. It is for patients with specific, less common types of kidney cancer. Participants are randomly assigned to take one…

This study is testing whether combining three different cancer drugs can better control two aggressive types of blood cancer: Philadelphia chromosome-positive acute myeloid leukemia (AML) and advanced chronic myeloid leukemia (CML). The trial will enroll about 20 adults with thes…

This study is testing a new combination treatment for people with a specific type of advanced throat cancer caused by HPV. It combines two immunotherapy drugs (nivolumab and ipilimumab) that help the body's immune system fight cancer, along with a targeted, lower-dose radiation t…

This study is testing whether delivering a single, large dose of targeted radiation is as effective as the standard three smaller doses for treating spinal tumors that have grown back after previous radiation. It involves 80 adults with cancer that has spread to the spine. The ma…

This early-stage study is testing whether combining two targeted drugs, amivantamab and tepotinib, can help control advanced non-small cell lung cancer that has specific changes in a gene called MET. The main goals are to find a safe dose for the combination and to get an early l…

This early-stage study is testing a new experimental treatment called NBTXR3 for people with locally advanced pancreatic cancer that is difficult to remove with surgery. The treatment involves injecting tiny nanoparticles directly into the tumor, which are then activated by a sta…

This study followed 86 patients with kidney cancer that had spread to other body parts after they had surgery to remove those secondary tumors. The goal was to see if this surgical approach helps keep the cancer from progressing or returning. Researchers tracked patients' health …

This early-stage trial is testing whether combining existing cancer drugs with a new experimental drug (LY3214996) can help control advanced colorectal cancer that has stopped responding to standard treatments. The study aims to find safe doses and see if these combinations can s…

This study is testing a shorter, more targeted form of radiation therapy using proton beams for patients with early-stage breast cancer. The goal is to see if this approach effectively controls the cancer while causing fewer side effects and better cosmetic results compared to tr…

This study is testing whether two oral cancer drugs, venetoclax and decitabine, can help control a fast-growing blood cancer called acute myeloid leukemia (AML) in adults for whom prior treatments have stopped working. The goal is to see if this combination can reduce cancer cell…

This early-stage trial aims to find safe doses and understand side effects of several drug combinations for patients with advanced cancers that haven't responded to standard treatments. The study involves 155 participants with various advanced or metastatic cancers and some rare …

This study is testing a personalized cell therapy called LN-145 for patients with advanced cancers that have stopped responding to standard treatments. Doctors collect a patient's own immune cells from their tumor, grow large numbers of them in a lab, and then infuse them back in…

This study is testing whether giving an immunotherapy drug called cemiplimab before surgery helps treat a type of skin cancer on the head and neck. The drug is designed to help the body's own immune system attack the cancer cells. Researchers want to see if the treatment shrinks …

This study is testing whether using MRI scans to guide the placement of internal radiation therapy can improve treatment for women with certain stages of cervical or vaginal cancer linked to HPV. The goal is to see if this method helps deliver radiation more precisely to the tumo…

This study is testing a combination of three drugs—azacitidine, venetoclax, and pevonedistat—for adults newly diagnosed with certain high-risk blood cancers. These include acute myeloid leukemia (AML) that developed from other blood disorders or prior cancer treatment, as well as…

This study is testing whether a 3-4 week pulmonary rehabilitation program can improve lung function in lung cancer patients who currently don't qualify for surgery. The program includes supervised exercise training, education, and counseling to help patients build strength and br…

This study is for people with stage IV non-small cell lung cancer. It tests if adding local treatments like surgery or radiation to a two-drug immunotherapy regimen helps patients live longer than immunotherapy alone. The trial enrolled 339 patients who had not progressed after a…

This study is testing whether proton beam radiation therapy can help control a rare type of skull base tumor called chondrosarcoma. Fifteen patients who have already had surgery to remove as much tumor as possible will receive daily proton beam treatments for about 7 weeks. Resea…

This is a first-in-human study to find a safe dose of an experimental antibody drug called Hu8F4 for patients with advanced blood cancers like leukemia and myelodysplastic syndrome (MDS). The main goals are to check for side effects and see how the body processes the drug. The st…

This study is testing a three-drug chemotherapy combination for people with advanced cancers in the nasal cavity or sinuses who haven't had treatment yet. The goal is to see if these drugs can shrink the tumors enough to improve the success of follow-up radiation or surgery, and …

This early-stage study is testing whether two immunotherapy drugs (ipilimumab and nivolumab) can be safely combined with radiation therapy for patients with stage II or III non-small cell lung cancer. The goal is to see if this combination helps the immune system attack the cance…

This study is testing whether a two-drug combination (azacitidine and venetoclax) can help keep acute myeloid leukemia (AML) from returning in patients who have achieved remission. The trial will enroll 50 adults with AML who are in remission but are not immediate candidates for …

This study tests whether taking two oral medications together—venetoclax and ibrutinib—can better control chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). It is for adults whose cancer has returned after prior treatment or who have high-risk, untreated dis…

This study is testing whether a targeted pill called selpercatinib can shrink thyroid tumors before surgery. It is for people with advanced thyroid cancer that has a specific genetic change (RET alteration). The goal is to see if shrinking the tumor first makes surgery easier and…

This early-stage trial is testing four different combinations of experimental drugs with existing cancer medications for people with metastatic solid tumors. The study aims to find safe doses and see if these combinations can shrink tumors in seven specific cancer types. It's des…

This early-stage study is testing the safety and best doses of a drug called neratinib when given with one of three other cancer drugs (everolimus, palbociclib, or trametinib). It is for adults with advanced solid tumors that have specific genetic mutations and have stopped respo…

This early-stage study is testing the safety of a two-drug immunotherapy combination (durvalumab and tremelimumab) given before surgery to patients with aggressive bladder and related urinary tract cancers. The trial is specifically for patients who cannot receive the usual pre-s…

This study is testing whether a Mediterranean diet is a practical and helpful option for medically underserved men with prostate cancer. It will enroll 25 Hispanic and Black/African American men from a specific Houston hospital. The main goal is to see if participants can stick w…

This early-stage study is testing whether delivering a chemotherapy drug called paclitaxel directly into the abdominal cavity is safe and tolerable for people with advanced stomach or gastroesophageal cancer that has spread to the lining of the abdomen. The main goal is to find t…

This study is testing a counseling program delivered by smartphone to help pregnant women who smoke and have depression. The program aims to help them quit smoking and improve their mood both during pregnancy and after their baby is born. Researchers are comparing two types of co…

This study is testing a treatment for a viral infection called CMV that can be dangerous for people who have had a stem cell transplant. It uses special white blood cells from a donor who has fought off CMV before. The goal is to see if these 'borrowed' immune cells can help clea…

This study is testing a new four-drug combination (rituximab, lenalidomide, acalabrutinib, tafasitamab) given before and alongside standard chemotherapy for adults newly diagnosed with a hard-to-treat type of aggressive lymphoma (non-germinal center DLBCL). The goal is to see if …

This early-stage study is testing a new combination of two drugs, DS3201 and ipilimumab, for people with advanced prostate, bladder, or kidney cancer that has spread. The main goals are to find the safest dose and understand the side effects. Researchers hope the drug combo will …

This study aims to find out which of two chemotherapy combinations works better for treating advanced head and neck cancer that hasn't been treated before. Researchers will compare two different drug regimens in about 128 patients to see which one better controls the cancer while…

This is an early-stage study to find the safest dose of two oral drugs, cabozantinib and pamiparib, when given together. It is for adults with advanced solid tumors that have spread or stopped responding to standard treatments. The goal is to see if blocking multiple cancer growt…

This study is testing whether having a health coach, called a patient navigator, helps obese adults enroll in and stick with proven weight management programs. Researchers are comparing two groups: one gets basic program information, while the other gets that information plus reg…

This is an early safety study to see if injecting a drug called nivolumab directly into high-risk mouth lesions is safe and tolerable. The goal is to see if this local treatment can shrink or eliminate these precancerous spots to prevent them from developing into head and neck ca…

This study is testing an experimental drug called XmAb20717 in adults with advanced rare cancers that have few treatment options. The main goals are to see if the drug is safe and if it can shrink tumors or slow their growth. The trial is currently suspended and is not enrolling …

This study is testing if giving a short, focused dose of radiation right before breast cancer surgery can help the patient's own immune system fight the tumor. It involves 25 patients with a common type of hormone-positive, HER2-negative breast cancer. The main goal is to see if …

This study is testing a new type of personalized cell therapy called IVS-3001 in adults with advanced solid tumors that have stopped responding to standard treatments. The therapy involves modifying a patient's own immune cells to recognize and attack cancer cells that carry a sp…

This study is testing if adding a drug called telotristat ethyl to standard hormone therapy better protects the heart in patients with advanced neuroendocrine tumors. About 80 patients will be randomly assigned to receive either the new drug combination or a placebo with standard…

This study is testing whether a combination of two drugs, acalabrutinib and rituximab, can effectively control mantle cell lymphoma in older adults who have not yet received any treatment. The goal is to see how well this drug pair works to put the cancer into remission and to un…

This study is testing a new three-drug combination to control B-cell non-Hodgkin lymphoma. It aims to find the safest dose and see if adding a new immunotherapy drug (ALX148) to two existing drugs (rituximab and lenalidomide) helps patients whose cancer has returned or is newly d…

This study is testing whether proton beam radiation therapy can effectively control chordoma tumors at the base of the skull. Researchers want to find the right dose that treats the tumor while minimizing side effects. The treatment involves daily radiation sessions for about 7 w…

This study is testing if adding an experimental drug called BMS-986504 to standard chemotherapy helps control pancreatic cancer in people whose tumors have a specific genetic change called an MTAP deletion. It aims to see if the combination is safe and can slow cancer growth or i…

This study is testing whether combining an experimental drug (DKN-01) with an approved immunotherapy (pembrolizumab) can help control advanced or recurrent endometrial cancer. It will involve about 8 women with specific types of this cancer to see if the treatment is effective an…

This study is testing whether two oral medications, lenvatinib and everolimus, can help control advanced carcinoid tumors that have spread and cannot be surgically removed. The trial aims to see if the drug combination can shrink tumors or stop their growth, and to monitor side e…

This study is testing whether combining two existing drugs, ruxolitinib and azacytidine, is a better treatment for people with myelofibrosis and related blood cancers. The trial enrolled 121 patients to see if this combination can improve their disease status more effectively tha…

This study is testing a new two-drug combination for people with advanced colorectal cancer that has spread and is no longer responding to standard chemotherapy. The trial combines an experimental pill called SX-682, which aims to block tumor growth, with an existing immunotherap…

This early-stage trial is testing a combination of two oral drugs, binimetinib and hydroxychloroquine, for people with advanced pancreatic cancer that has a specific genetic change (KRAS mutation). The main goal is to find the safest and most effective dose of hydroxychloroquine …

This study is testing a combination of four drugs (brentuximab vedotin, pembrolizumab, doxorubicin, and dacarbazine) for people with advanced or bulky Hodgkin lymphoma who haven't had treatment before. Researchers are using PET scans during treatment to see if they can adjust the…

This study tested whether the immunotherapy drug pembrolizumab could help control the growth of rare, advanced cancers that have spread or cannot be removed by surgery. It involved 157 patients with specific rare tumor types who had already tried standard treatments. The goal was…

This study is testing whether combining the immunotherapy drug pembrolizumab with the standard antibody rituximab (with or without the drug lenalidomide) can help control lymphoma that has come back after previous treatment. It is for adults with specific types of B-cell lymphoma…

This study tested whether combining two drugs, letrozole and everolimus, could help control advanced or returning endometrial cancer. It involved 42 patients whose cancer had progressed or returned after prior treatments. Researchers monitored if tumors shrank or stopped growing …

This study is testing a combination of two drugs for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or hasn't responded to other treatments. The goal is to see if the combination is safe and effective at controlling the dis…

This study is testing a new treatment plan for younger adults newly diagnosed with mantle cell lymphoma, a type of blood cancer. The plan combines several targeted drugs that attack cancer cells in different ways, followed by a standard chemotherapy regimen. The main goal is to s…

This early-stage trial is testing whether a specialized form of radiation therapy is safe for people with liver cancer who also have poor liver function or a reduced amount of healthy liver tissue. The study will enroll 36 patients to find the highest safe dose of radiation that …

This study is testing if adding local treatments like surgery and radiation to standard drug therapy helps control breast cancer that has spread to the bones for a longer time. It involves patients whose cancer has spread to only 1-3 bone sites. The goal is to see if aggressively…

This early-stage study is testing whether combining an existing arthritis drug (sarilumab) with an existing cancer immunotherapy (cemiplimab) can help control advanced non-small cell lung cancer. It is enrolling 56 adults whose cancer has specific genetic changes (EGFR or LKB1 mu…

This study is testing whether a radioactive treatment for advanced liver cancer can be safely done in a single day instead of the usual two separate visits. The treatment involves injecting tiny radioactive beads directly into the liver's blood vessels to cut off tumors' blood su…

This study is testing whether two oral drugs, venetoclax and ASTX727, can help control acute myeloid leukemia (AML). It is for adults whose AML has come back or hasn't responded to prior treatment, or for older, newly diagnosed patients who cannot tolerate strong chemotherapy. Th…

This study is testing if a combination of two drugs, fulvestrant and abemaciclib, can help control advanced low-grade ovarian cancer. It involves 18 women who will receive the drugs before and after their planned surgery. The main goal is to see if this approach shrinks or stabil…

This study is testing whether combining immunotherapy drugs with targeted radiation to the brain works better to control advanced lung cancer that has spread there. It aims to find the safest and most effective doses of the drugs nivolumab and ipilimumab when given with two diffe…

This study is testing if a drug called pegloticase can quickly lower dangerously high uric acid levels in cancer patients. High uric acid is a side effect of some cancer treatments and can damage the kidneys. The goal is to see if one or two doses of pegloticase can protect kidne…

This early-stage study is testing a new combination of two drugs, valemetostat and trastuzumab deruxtecan, for people with advanced breast cancer that has low or no HER2 protein. The main goals are to find a safe and effective dose and to see if the treatment can shrink tumors. I…

This study is testing an oral medication called talazoparib for people with advanced cancers that have spread, returned, or stopped responding to standard treatments. It is specifically for patients whose cancers have certain genetic changes in the BRCA pathway (like BRCA1, BRCA2…

This study is testing whether combining the drugs Avastin and Tencentriq, with or without a third drug called Cotellic, can help control melanoma that has spread to the brain. It is for adults with this specific type of advanced skin cancer who have not yet received treatment for…

This study is testing if a supervised, at-home exercise program done during chemotherapy can help people with pancreatic cancer who are planning for surgery. It compares a structured video workout plan to general activity advice to see if it helps patients start follow-up chemo s…

This early-stage trial is testing the safety and best dose of a three-drug combination (vemurafenib, cetuximab, and irinotecan) for patients with advanced solid tumors that have spread and carry a specific BRAF gene mutation. The goal is to see if combining these drugs—two that b…

This is a small, early-stage study to see if a combination of two drugs, pembrolizumab and lenvatinib, can help control advanced pancreatic cancer that has worsened after initial treatment. The study will enroll about 15 patients to check if the treatment shrinks tumors and is sa…

This study tests whether a precise form of radiation called stereotactic radiosurgery (SRS) can control lung cancer that has spread to the brain while better preserving patients' memory and thinking abilities. It compares SRS, which targets only the tumors, to standard whole-brai…

This study is testing a new treatment approach for adults with acute lymphoblastic leukemia (ALL) that has returned or not responded to prior therapy. It combines a targeted drug called venetoclax with a lower-intensity chemotherapy regimen. The goal is to see if this combination…

This study is testing whether eating a high-fiber diet can improve gut health and help the immune system fight cancer in patients with advanced melanoma who are receiving standard immunotherapy. Fifty participants will be randomly assigned to follow either a high-fiber diet or a …

This study tested whether the immunotherapy drug pembrolizumab could help control advanced inflammatory or triple-negative breast cancer in patients whose disease had already responded to or stabilized with chemotherapy. The trial involved 71 participants with these aggressive fo…

This trial is testing whether adding a new drug called LY3295668 to an existing lung cancer drug (osimertinib) can help control cancer that has stopped responding to standard treatment. It involves 32 adults with a specific type of advanced lung cancer (EGFR-mutant non-small cell…

This study is testing whether combining two immunotherapy drugs (nivolumab and ipilimumab) with a chemotherapy drug (azacitidine) is safe and effective for treating myelodysplastic syndromes (MDS), a type of blood and bone marrow cancer. It is for 99 patients, including those new…

This study tests whether adding the immunotherapy drug pembrolizumab to standard hormone therapy helps prevent cancer from returning in patients with a specific, aggressive type of breast cancer. It is for people whose cancer did not completely disappear after initial chemotherap…

This is a first-in-human study to test the safety and find the right dose of a new, personalized cell therapy called OBX-115, given with the drug acetazolamide. It is for adults whose metastatic melanoma has come back or stopped responding to standard immunotherapy. Researchers w…

This study tested a combination of three drugs—two chemotherapy drugs and an immunotherapy drug—as the main treatment for stage II-III larynx (voice box) cancer. The goal was to see if this approach could effectively control the cancer while allowing patients to keep their larynx…

This study is testing whether adding the drug ponatinib to a specific chemotherapy regimen and another drug called venetoclax can help patients whose T-cell acute lymphoblastic leukemia has returned or not responded to prior treatment. It aims to see if this combination can put t…

This study is testing whether adding a drug called venetoclax to the standard chemotherapy given before a donor stem cell transplant works better for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to better prepare the body to accept the…

This study is testing if combining a targeted, high-dose radiation treatment with an immunotherapy drug works better than radiation alone for certain early-stage or recurrent non-small cell lung cancers. About 140 participants will be randomly assigned to receive either the radia…

This study is testing a multi-step treatment to control a fast-spreading and hard-to-treat form of prostate cancer. It will involve about 120 men whose cancer has spread and is resistant to standard hormone therapy. The goal is to see if combining chemotherapy, a drug that helps …

This study is testing whether a shorter, more intense 3-week radiation schedule works as well as the standard 5-week schedule for women with early-stage breast cancer. It aims to see if the shorter treatment is just as effective at controlling cancer while possibly causing fewer …

This study is testing whether a combination of three drugs can help control prostate cancer that has spread to other parts of the body. Researchers want to see if they can predict which patients will respond best to this treatment by analyzing tumor characteristics. The trial inv…

This study is testing a new combination of three drugs (ciforadenant, ipilimumab, and nivolumab) to see if it can help control advanced kidney cancer that has spread. It will involve about 50 adults who have not yet received any treatment for their advanced cancer. The main goals…

This study is testing the safety and effectiveness of avelumab, an immunotherapy drug, when given in combination with other immune-boosting drugs and sometimes radiation. It is for patients with advanced solid tumors that have spread and who have run out of standard treatment opt…

This early-stage trial aims to find the safest, most effective doses of four different drug combinations for patients with advanced cancer that hasn't responded to standard treatments. Researchers are testing vorinostat paired with one of three other drugs (sirolimus, everolimus,…

This early-stage study is testing a new personalized cell therapy called KSQ-001EX in people with advanced melanoma, lung cancer, or head and neck cancer. Doctors take a patient's own immune cells from a tumor, genetically modify them to potentially be more powerful, and then inf…

This study is testing whether patients with early-stage HER2-positive or triple-negative breast cancer can safely stop or reduce their medication after surgery. It focuses on patients whose cancer disappeared completely with pre-surgery treatment and who show no signs of leftover…

This study aims to see if adding the antiviral drug cidofovir to standard supportive care improves symptoms of BK virus-related hemorrhagic cystitis (painful bladder bleeding) in patients who have had a stem cell transplant. Participants were randomly assigned to receive either s…

This study is testing whether a radioactive drug called 177Lu rhPSMA-10.1 is safe and effective when given to men with high-risk prostate cancer before they have surgery to remove the prostate. The first phase checks if the drug dose is safe, and if so, the second phase will test…

This study is testing a modified stem cell transplant procedure for patients with high-risk blood cancers. The goal is to see if using specific chemotherapy drugs in a timed sequence before and after the transplant can better control the cancer while reducing harmful immune react…

This study is testing a combination of two drugs, pembrolizumab and romidepsin, for people with a type of blood cancer called peripheral T-cell lymphoma that has come back or hasn't responded to previous treatments. The goal is to see if using these drugs together is safe and mor…

This study is testing a combination of two drugs, trametinib and pembrolizumab, for people with advanced non-small cell lung cancer that has come back or spread after previous treatments. The goal is to see if the drugs work better together to control the cancer and to find the s…

This study tested two common quit-smoking treatments to see which works better and what to do next if the first attempt fails. Over 600 smokers received either varenicline (a prescription pill) or combined nicotine patches and lozenges, along with counseling. The trial specifical…

This early-stage trial is testing the safety and best doses of two different combinations of oral medications for people with recurrent endometrial, ovarian, or triple-negative breast cancer. The study combines an existing drug (olaparib) with one of two newer drugs (AZD2014 or A…

This study aims to find the safest and most effective dose for giving radiation therapy a second time to patients whose brain tumors have returned after previous radiation. It will closely monitor patients for serious side effects, particularly damage to healthy brain tissue, whi…

This study is testing whether combining three different drugs works better for people with chronic lymphocytic leukemia (CLL) or a more aggressive form called Richter transformation that has returned or hasn't responded to other treatments. The combination includes two immunother…

This early-stage study is testing three different immunotherapy drug combinations in patients with advanced kidney cancer that has spread. The main goal is to see which combination is safest and causes the fewest side effects when given before surgery to remove the cancer. Resear…

This study aims to find the best order to give three existing kidney cancer drugs to patients whose cancer has spread. Researchers are testing six different two-drug sequences to see which order works best to control the disease and is safest. The trial involves 180 patients with…

This was an early, withdrawn study to test the safety of a personalized vaccine for a rare and aggressive skin cancer called angiosarcoma. The vaccine would have been made from a patient's own immune cells and tumor tissue. The main goal was to find a safe dose and see if the bod…

This early-stage study is testing a new combination treatment for advanced solid tumors that have stopped responding to standard therapies. Researchers are injecting a modified, non-toxic bacteria directly into a tumor to help break it down, while also giving an immunotherapy dru…

This small pilot study is testing whether feeding tube nutrition is safe and practical for people recovering from stem cell transplants. Researchers are comparing feeding tube nutrition to standard nutrition methods to see which approach better supports recovery, quality of life,…

This early-stage study is testing the safety of a new personalized treatment for advanced melanoma. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then infuse them back into the body. The goal is to see if th…

This study is testing if a single, highly focused dose of radiation to the area where a brain tumor was removed works better than just watching and waiting. It aims to see if this targeted treatment can prevent the cancer from growing back in the same spot for at least six months…

This study is testing two advanced, precise ways to deliver radiation therapy alongside standard chemotherapy for people with stage II or III non-small cell lung cancer. The goal is to see if these methods can safely deliver a stronger dose of radiation directly to the tumor whil…

This study is comparing two ways to give radiation after breast cancer surgery. It tests if a shorter, 5-day treatment that targets only the tumor area is as safe and effective as the standard 15-day treatment. The goal is to see if the shorter course can control the cancer just …

This study is testing whether a hormone-releasing intrauterine device (IUD) works better alone or combined with an oral drug called everolimus to treat early-stage uterine cancer or a serious pre-cancerous condition. The goal is to see if this approach can control or eliminate th…

This early-stage trial is testing whether a shorter, 2-week course of combined chemotherapy and radiation before surgery is safe and effective for patients with operable stomach cancer. The study involves 25 participants and compares this shorter approach to the standard 5-week t…

This study is testing a combination of intensive chemotherapy (called Hyper-CVAD) and a targeted drug called ponatinib for adults with a specific type of acute lymphoblastic leukemia (ALL) that involves a genetic change called Philadelphia chromosome or BCR-ABL. The main goal is …

This study is testing a new smartphone app designed to help people quit smoking. The app creates a personalized schedule to gradually reduce smoking before quitting completely. Researchers want to see if using this app, along with nicotine patches, is a helpful and practical way …

This early-phase study is testing whether a very low dose of radiation can effectively treat a rare, slow-growing stomach lymphoma called MALT. The goal is to see if this approach can shrink or eliminate the tumor while causing fewer side effects than standard treatments. Researc…

This study is testing a combination of two drugs, ibrutinib and rituximab, for people with mantle cell lymphoma, a type of blood cancer. It is for two groups: those whose cancer has returned or hasn't responded to prior treatment, and older patients newly diagnosed with the disea…

This study is testing if a new pill form of the cancer drug cladribine works similarly to the standard version given through an IV. It involves 40 adults with specific types of leukemia. The main goal is to find the right pill dose that delivers the same amount of drug into the b…

This study is testing whether adding the immunotherapy drug elotuzumab to standard maintenance therapy (lenalidomide) helps keep multiple myeloma from returning after a patient's own stem cell transplant. The trial involves 113 patients who have recently undergone transplant for …

This early-stage study is testing a new, personalized DNA vaccine designed to teach the body's immune system to recognize and attack lymphoma cells. It aims to find the safest dose and see if the vaccine triggers an immune response in patients with early, symptom-free disease. Th…

This study compares two different drug treatments for people with advanced kidney cancer that has spread and continued to grow despite previous immunotherapy. Researchers want to see whether a combination of two drugs (lenvatinib plus everolimus) works better than a single drug (…

This study is testing whether combining chemotherapy with surgery to remove lung tumors works better than either treatment alone for colorectal cancer that has spread only to the lungs. Patients are divided into low-risk and high-risk groups, with each group receiving different t…

This study is testing the safety of adding a new immunotherapy drug (MPDL3280A) to the standard treatment of chemotherapy and radiation for patients with non-small cell lung cancer that cannot be removed by surgery. The goal is to see if this three-part combination is safe and ca…

This early study is testing whether a drug called olaparib can help shrink tumors before surgery in people newly diagnosed with advanced ovarian cancer that has a BRCA gene mutation. The trial involves about 15 participants who will take olaparib pills for up to two months before…

This study is testing a two-part treatment approach for younger patients newly diagnosed with mantle cell lymphoma, an aggressive type of blood cancer. First, patients receive a targeted pill (ibrutinib) plus an immunotherapy drug (rituximab) to attack the cancer cells. If they r…

This study is testing different combinations of approved drugs to find better ways to control advanced prostate cancer that has spread and stopped responding to standard hormone therapy. It involves 196 men and uses a personalized approach: after an initial 8-week treatment, pati…

This study is testing a new, personalized approach to treat acute myeloid leukemia (AML) when it starts to come back. Doctors will use genetic information from a patient's cancer to choose specific drug combinations, aiming to attack the disease early based on tiny traces of left…

This study aimed to test a two-drug combination (regorafenib and lorigerlimab) given before surgery to patients with colorectal cancer that had spread only to the lungs. The goal was to see if the treatment was safe and could shrink the lung tumors to make surgery more effective.…

This early-stage study is testing the safety and best dose of combining standard chemotherapy drugs with a portable device that uses electrical fields to try to stop tumor growth. It is for patients whose cancer has spread to the liver and has not responded to other treatments. T…

This study is testing a new combination of two drugs, venetoclax and azacitidine, for patients with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) that has come back or stopped responding to standard treatment. The first part of the study aims …

This study is testing two special imaging tools to help surgeons see the edges of a breast tumor more clearly during surgery. The goal is to remove all the cancer in one operation, reducing the need for a second surgery and potentially improving cosmetic results. It involves 175 …

This study is testing if adding the drug sorafenib to standard chemotherapy drugs (busulfan and fludarabine) is safe and effective for adults with acute myeloid leukemia (AML) that has returned or not responded to treatment. The goal is to better prepare patients for a stem cell …

This study is testing whether two immunotherapy drugs, oleclumab and durvalumab, can help control advanced sarcomas that have come back, stopped responding to treatment, or spread. It is for adults and teens (12+) with specific types of sarcoma, including angiosarcoma, dedifferen…

This study is testing a new combination of treatments for people with extensive-stage small cell lung cancer who haven't had treatment yet. It combines a targeted drug (olaparib), an immunotherapy drug (durvalumab), standard chemotherapy, and radiation. The goal is to see if this…

This study is testing whether a combination of two drugs, sacituzumab govitecan and pembrolizumab, can help control early-stage triple-negative breast cancer when given before surgery. It is for patients whose cancer did not shrink after their initial round of chemotherapy and im…

This study is testing whether adding immunotherapy drugs to standard chemotherapy before surgery can better control cancer in the esophagus or where the stomach meets the esophagus. The goal is to shrink the tumor as much as possible before an operation to remove it. Researchers …

This study is testing whether the drug regorafenib can help control rare, hard-to-treat types of gastrointestinal stromal tumors (GIST) that have specific genetic mutations. It is for adults whose cancer has continued to grow despite standard first-line treatment. The main goal i…

This study is testing whether two different drug combinations can help control recurrent ovarian, fallopian tube, or primary peritoneal cancer that has continued to grow despite previous treatment with a specific type of targeted therapy called a PARP inhibitor. It will enroll ab…

This early-stage study is testing a personalized vaccine made from a patient's own tumor cells and blood. It aims to see if creating and giving this custom vaccine is safe and possible for people with advanced pancreatic or colorectal cancer that has spread. The vaccine is design…

This study aims to find the most effective way to help smokers quit when they come in for a lung cancer screening scan. Researchers are comparing different types of counseling support and may offer FDA-approved quit-smoking medications. The goal is to use the screening appointmen…

This study is testing a shorter, more convenient 3-week radiation schedule for patients with soft tissue sarcoma in the arms, legs, or trunk who need surgery. The goal is to see if this shorter treatment works as well as the standard 5-6 week course at controlling the cancer and …

This study is testing a combination of three immunotherapy drugs—tocilizumab, ipilimumab, and nivolumab—in patients with advanced melanoma, non-small cell lung cancer, or bladder cancer. The main goal is to see if adding tocilizumab can help manage the serious side effects someti…

This early-stage study is testing an inhaled form of an immune-boosting drug (aldesleukin) for people whose cancer has spread to their lungs. The main goals are to find a safe dose and see if the treatment causes side effects. Researchers also want to learn if inhaling the drug d…

This study is testing if combining time-restricted eating (fasting for at least 16 hours each night) with the diabetes drug metformin can slow the growth of early-stage breast cancer. It involves 120 women who are scheduled for surgery. The goal is to see if this combination redu…

This study is testing if a simple blood test can help doctors choose the best treatment for patients with advanced colorectal cancer that has spread. The test looks for tiny pieces of tumor DNA in the blood. Researchers want to see if using this test to guide treatment leads to f…

This study is testing whether permanently implanting tiny radioactive seeds into the prostate can effectively control intermediate-risk prostate cancer. Researchers will track 300 patients to see if their PSA levels remain stable and monitor side effects. The goal is to determine…

This study is testing if taking a hormone therapy drug called apalutamide for 6 months before prostate removal surgery can improve outcomes for men with intermediate-risk prostate cancer. The main goal is to see if this pre-surgery treatment reduces certain high-risk features in …

This study is testing whether a combination of two immunotherapy drugs, nivolumab and relatlimab, can help control advanced renal medullary carcinoma (RMC), a rare and aggressive type of kidney cancer. The trial will enroll about 30 adults whose cancer has spread or cannot be rem…

This study tests an experimental drug called vibecotamab in adults with two types of blood cancer: acute myeloid leukemia (AML) that still shows tiny amounts of cancer after treatment, and myelodysplastic syndrome (MDS) that has stopped responding to standard medications. The goa…

This study is testing a combination of three drugs (encorafenib, cetuximab, and nivolumab) for people with advanced colorectal cancer that has a specific BRAF gene mutation and has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the three dr…

This study is testing a combination of two drugs, zanubrutinib and rituximab, for people newly diagnosed with a type of blood cancer called chronic lymphocytic leukemia (CLL). The main goal is to see if this treatment can control the cancer well enough that patients can safely st…

This early-stage study is testing a new drug, ALRN-6924, combined with a standard chemotherapy (paclitaxel) for people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find the safest and most effective dose of this combination an…

This early-stage study is testing the safety of a new combination treatment for people with advanced solid tumors that have spread. The treatment combines two immunotherapy drugs with a special type of targeted radiation. It is for patients who have very limited life expectancy a…

This study is testing whether a combination of four drugs can help control advanced colorectal cancer that has stopped responding to standard treatments. It is for adults with a specific type of cancer called microsatellite stable (MSS) colorectal cancer. The main goals are to se…

This study is testing an experimental immunotherapy drug called AK104 for women with a rare, aggressive form of cervical cancer that has returned or spread after prior chemotherapy. The main goal is to see if the drug can keep the cancer from growing for at least 6 months. Resear…

This early-phase study is testing a three-step treatment for people newly diagnosed with a high-risk form of mantle cell lymphoma, a type of blood cancer. First, patients receive two drugs (acalabrutinib and rituximab), followed by an infusion of their own genetically modified im…

This study is testing whether a very low dose of radiation aimed at the eye socket can effectively control slow-growing B-cell lymphomas that involve the eye area. It aims to see if this lower dose can work as well as standard treatments while causing fewer side effects. The tria…

This is an early-stage study to find the safest dose of a new drug, MGN1703, when given with an existing immunotherapy drug, ipilimumab. It involves about 60 people with advanced solid tumors that have not responded to standard treatments. The main goals are to see how much of th…

This study is testing whether a combination of two immunotherapy drugs, atezolizumab and tiragolumab, can help control cancer of unknown primary. It is for adults whose cancer has spread and who have already tried or cannot have standard chemotherapy. The main goals are to see if…

This study aims to find out if adding the immunotherapy drug rituximab to the cancer drug ibrutinib works better than ibrutinib alone for adults whose chronic lymphocytic leukemia has returned after prior treatment. It will compare how long patients stay cancer-free on each regim…

This study is testing a combination of three drugs for people with advanced bladder cancer that has a specific genetic flaw called MTAP deficiency and has stopped responding to standard immunotherapy. The goal is to see if this new combination is safe and can help control the can…

This study is testing whether adding an experimental pill called GSK2636771 to an approved immunotherapy drug (pembrolizumab) can help control advanced melanoma that has not responded to prior treatment and has a specific genetic feature called PTEN loss. The main goals are to fi…

This study aimed to test if a combination of two drugs, regorafenib and lorigerlimab, could shrink rectal cancer tumors that had started to grow back or returned locally after a patient's first round of treatment. The goal was to see if this drug combo could reduce the cancer eno…

This early-stage study is testing a new drug called NBTXR3, given as an injection directly into lung tumors, along with radiation therapy. The goal is to find the safest dose and see if the drug helps the radiation work better to kill cancer cells in people whose non-small cell l…

This study is testing whether a combination of three existing drugs can help control advanced or returning endometrial (uterine) cancer. The drugs—everolimus, letrozole, and metformin—work in different ways to potentially slow or stop cancer growth. The trial will enroll 62 patie…

This study is testing whether using MRI scans to guide radiation therapy can allow doctors to safely use lower radiation doses for certain throat cancers. It focuses on patients with HPV-positive throat cancer who have a low risk of the cancer spreading. The goal is to control th…

This study is testing whether adding an oral drug called azacitidine to the immunotherapy pembrolizumab can help control advanced melanoma. It is for patients who are new to this type of immunotherapy or whose cancer has worsened despite it. The main goal is to see if the combina…

This study is testing whether adding an experimental vaccine (PDS0101) to standard chemotherapy and radiation is safe for patients with locally advanced cervical cancer. The vaccine is designed to help the immune system target cancer cells linked to HPV. Researchers will enroll a…

This study aims to see if MRI scans can be as accurate as CT scans for determining the stage of thymoma tumors before surgery. Researchers will compare both types of scans against surgical findings in 40 adult patients with thymoma. The goal is to determine if MRI could provide s…

This study is testing a new type of 3D MRI scan for men with prostate cancer. The goal is to see if this new scan can create clear pictures of the prostate without requiring an uncomfortable rectal coil during the procedure. Researchers will compare the image quality of the new 3…

This study is testing new artificial intelligence (AI) software designed to improve the quality of CT scan images of the liver. The goal is to see if these AI-enhanced images, taken with a lower dose of radiation, can detect liver metastases (cancer spread) as accurately as stand…

This study aims to find better ways to screen for liver damage and cancer risk in patients at a Houston community clinic. Researchers are testing whether simple surveys and blood tests can accurately identify patients who need more advanced scans for liver scarring. The goal is t…

This study is testing whether a new radioactive imaging agent, called [18F]FluorThanatrace, can improve PET/CT scans for breast cancer. The goal is to see if this tracer can better detect an enzyme linked to cancer growth. The trial involves 36 adults with breast cancer who are s…

This study is testing a new type of MRI scan to see if it can better find and pinpoint prostate cancer tumors. It uses a special imaging agent called hyperpolarized pyruvate, which may help the scanner see chemical changes in cancer cells. The goal is to develop a more accurate e…

This study is testing a special imaging scan to see if it can predict how well chemotherapy works for women with breast cancer before they have surgery. The scan is done before, during, and after chemotherapy to see if changes in the tumor can show early signs of treatment succes…

This study is testing if two methods—a combined PET/CT scan and a special dye used during surgery—can better find cancer that has spread to lymph nodes in patients with high-risk endometrial cancer. The goal is to see if these methods are as good as or better than the standard su…

This study is testing whether new imaging devices can help doctors better identify which suspicious spots in the mouth might turn into cancer. Researchers are comparing these advanced imaging techniques to standard visual exams in patients with pre-cancerous mouth conditions. The…

This study is testing whether a special type of CT scan, called a dual energy CT, can better detect carcinoid tumors in the digestive system. It involves 71 people who already have or are suspected to have these tumors. The goal is to see if this scan can find these tumors more a…

This study aimed to test a shorter, less expensive type of MRI scan for detecting prostate cancer. The goal was to see if this new scan, which doesn't use contrast dye, could find cancer as accurately as the standard, longer MRI. The study was designed for men with confirmed pros…

This study is testing new imaging tools that use special colored lights to look inside the mouth, aiming to spot pre-cancer or early cancer sooner than standard exams. It involves people at higher risk for oral cancer, such as those with white or red patches, a history of mouth i…

This study is testing if a special type of mammogram, called contrast-enhanced mammography (CEM), can better predict whether suspicious white spots (calcifications) seen on a regular mammogram are actually high-risk breast cancer. It involves 59 women who already need a biopsy fo…

This study is testing a combined PET/MRI scan to see if it can accurately measure how deep early-stage cervical cancer has grown into the cervix. It involves 25 patients who are scheduled for surgery to remove their cancer. The goal is to see if this detailed scan can provide bet…

This study is testing if using two different contrast dyes during an MRI scan can help doctors better see and identify spots on the liver, telling harmless ones apart from cancer. It involves people who have already had a recent liver MRI. Researchers will compare the accuracy of…

This study is testing if a needle biopsy can accurately tell when breast cancer has been completely eliminated by chemotherapy. If the biopsy shows no cancer, it might mean some patients could safely avoid surgery. Researchers are comparing the biopsy results to what is found dur…

This study aims to see if a single type of CT scan (CTU) can effectively monitor bladder cancer recurrence, potentially replacing the current standard practice of using two different scans (IVU and CT). Researchers are comparing the image quality and information provided by both …

This study is testing whether a newer type of combined PET/MR scan is better than the standard CECT scan at finding ovarian cancer tumors and predicting if they can be fully removed by surgery. About 21 patients with known or suspected ovarian cancer will receive both scans befor…

This study is testing if a special full-body MRI scan is better than the standard combination of bone and CT scans at finding out if high-risk prostate cancer has spread to the bones or lymph nodes. Men with high-risk prostate cancer will receive both the new MRI scan and the sta…

This study is testing whether a specialized catheter called TriNav can make liver cancer radiation treatment planning more accurate. Researchers want to see if using this device helps the test dose better predict where the actual radioactive treatment will go in the liver. The go…

This study is testing if a modified type of MRI scan can create better images of prostate cancer than the standard MRI. The goal is to help doctors see the cancer more clearly before a patient has surgery to remove the prostate. Men with confirmed prostate cancer who are schedule…

This study is testing if a medical cement procedure can prevent painful spinal fractures in cancer patients whose disease has spread to the spine. Patients at high risk for fracture receive either standard targeted radiation or radiation plus the cement procedure. The goal is to …

This study is testing different ways to help people at high risk for cancer or cancer survivors become more active and eat healthier foods. Researchers are comparing methods like weekly phone calls, emails, daily text messages, and online forums to see which combinations work bes…

This study compares three different approaches to prevent ovarian cancer in women who carry BRCA gene mutations. Participants choose between regular cancer screening, immediate removal of ovaries and fallopian tubes, or a new two-step surgery that removes tubes first and delays o…

This study is testing whether a comprehensive lifestyle program can help prevent breast cancer in premenopausal women at higher risk. The 60 participants are randomly assigned to either follow a 12-week program of diet changes, exercise, stress management, and counseling, or to r…

This study is testing whether the immunotherapy drug pembrolizumab can prevent lung cancer in people at high risk. It includes people with suspicious lung nodules that haven't grown or shrunk, and people who've had early-stage lung cancer treated before. Participants receive the …

This study is testing different methods to encourage more young adults in Texas to get vaccinated against HPV, a virus that can cause several cancers. Researchers are comparing six different approaches that include providing standard information, personal stories in video or writ…

This study is testing whether giving radiation to the whole brain can prevent brain tumors from developing in patients with an aggressive type of bladder cancer that has spread. The treatment is for patients whose cancer has responded well to chemotherapy but remains at high risk…

This study is testing a program called 'Tu Salud ¡Si Cuenta!' (Your Health Matters!) to help Latino families in Houston become more active and eat healthier foods. Community health workers visit families at home to teach skills like goal-setting and provide support. The goal is t…

This study is testing whether eating more magnesium-rich foods can prevent low magnesium levels in the blood, a common side effect of carboplatin chemotherapy for ovarian cancer. Researchers are working with 26 patients to see if this dietary approach is practical and effective. …

This study tests whether group education sessions can help women with BRCA gene mutations follow recommended cancer screening and prevention procedures. The program focuses on medically underserved women and racial/ethnic minorities who carry these high-risk genes. Researchers wi…

This study is testing whether eating canned beans can improve the healthy bacteria in your gut and lower the cancer risk linked to obesity. It involves people who are overweight and have a history of colorectal cancer or precancerous polyps. Participants are randomly assigned to …

This study tests a program called 'Your Health Matters!' that sends community health workers into Latino family homes to promote healthier lifestyles. The program provides education about physical activity and nutrition, helps families set goals, and sends weekly text message tip…

This study aims to understand why some African American women don't exercise often and to test if learning to support a partner's exercise habits can help them become more active. Researchers will enroll 80 sedentary women and their female friends or family members. One group wil…

This study is testing if adding a new drug called itacitinib to standard treatment can prevent a serious complication called graft-versus-host disease (GVHD) in patients who receive a donor stem cell transplant for blood cancers. GVHD happens when the donor's immune cells attack …

This study is testing whether more frequent screening for arm swelling (lymphedema) after breast cancer surgery can help prevent this painful side effect. Researchers are comparing intensive screening using a special measuring device against routine care in 260 patients. The goal…

This study tests whether family-focused coaching is better than parent-only coaching at reducing obesity risk in African American families. The goal is to find effective ways to lower the risk of obesity-related cancers that can run in families. Researchers are comparing three ap…

This study tests whether family-based support programs delivered through churches can help African American parents lose weight and improve their family's health. It compares two types of coaching and support groups against basic health education. The goal is to find effective co…

This study is comparing two different surgeries to prevent ovarian cancer in premenopausal women who have inherited genetic mutations that put them at high risk. One surgery removes both the fallopian tubes and ovaries at once, while the other removes just the tubes first and del…

This study is testing whether giving two doses of a pneumonia vaccine works better than one dose for people who have survived B-cell lymphoma. The goal is to see which approach gives stronger, longer-lasting protection against serious lung infections. The study involves 30 adults…

This program aims to help low-income pregnant women in Texas quit smoking and keep their homes smoke-free to improve their health and their baby's health. It offers phone counseling, a wellness app, and support materials to participants and their household members. The goal is to…

This study is testing different reminder messages to help people who smoke or used to smoke get screened for lung cancer. Researchers want to find the most effective way to remind eligible adults aged 40-80 to get this important preventive screening. The goal is to increase scree…

This study is testing whether a special surgical procedure can prevent a painful complication called lymphedema (arm swelling) in breast cancer patients having breast reconstruction. During reconstruction surgery, doctors transfer healthy lymph nodes from another part of the body…

This study is testing whether a 4-month diet and exercise program can help lower the risk of breast cancer. It focuses on postmenopausal women who are a normal weight but have high body fat, which can increase cancer risk. Researchers want to see if this lifestyle program is prac…

This study is testing if a diabetes prevention program, with or without extra training on recognizing hunger, can help people at high risk for breast cancer lose weight. The goal is to see if weight loss from these programs might lower cancer risk. The study enrolled 51 overweigh…

This study is testing different ways to help people with BRCA or Lynch syndrome gene mutations manage their weight and improve health habits to lower their cancer risk. Researchers are comparing methods like phone coaching, text message reminders, and family support groups to see…

This study aims to find the best schedule for draining fluid from the chest in people with advanced cancer. Researchers are comparing whether draining a small chest tube every day is more effective than draining it three times a week. The goal is to help patients breathe easier a…

This study is testing whether a technique called 'hypnosedation' can help patients relax during breast cancer surgery. It compares using hypnosis with local numbing medicine against standard general anesthesia. The goal is to see if hypnosis can reduce anxiety, pain, and the need…

This study is testing whether a form of acupuncture using mild electrical currents can help reduce long-term pain in women who have been treated for early-stage breast cancer. It will involve 111 women who have had persistent pain for at least 3 months after finishing cancer trea…

This study is testing whether combining physical activity with a short course of the steroid dexamethasone can reduce severe fatigue in people with advanced cancer. It enrolled 90 participants to compare a high-dose steroid week with a low-dose steroid week, both alongside a 4-we…

This study is testing whether adding a walking program to standard quit-smoking methods helps African American adults stop smoking. Researchers are comparing three groups: one that starts walking before their quit date, one that starts on their quit date, and one that doesn't wal…

This study compares two different methods of pain control for patients undergoing open surgery for liver cancer. Researchers want to see whether a traditional epidural or a newer nerve block helps patients recover more completely and leave the hospital sooner. The trial involves …

This study is exploring whether a treatment called neuromodulation can help reduce pain caused by nerve damage from chemotherapy. It will involve 24 adult patients at MD Anderson Cancer Center who have this specific type of pain in their legs and feet. Researchers will measure ch…

This study is testing whether adding weekly technology-based symptom check-ins to standard palliative care visits helps improve quality of life and symptom control for patients with advanced cancer. The trial involves 119 patients who are already enrolled in early-stage (Phase I)…

This study is testing a training program to help family members who care for loved ones with aggressive brain tumors. The program teaches practical caregiving skills with the goal of reducing distress for both the caregiver and the patient, and improving the patient's symptoms. R…

This study is testing different doses of steroid medication to see if they can improve symptoms like trouble swallowing and speaking in people who survived head and neck cancer. These symptoms are caused by nerve damage from radiation therapy received at least two years ago. The …

This study is testing whether a non-invasive brain stimulation technique can reduce nerve pain caused by a common chemotherapy drug. Researchers are comparing real magnetic stimulation to a fake (placebo) treatment and standard care in 56 cancer patients. The goal is to see if st…

This study is testing a combination of treatments to help cancer patients who are having trouble sleeping. It combines counseling sessions with possible use of a stimulant, melatonin, and light therapy. The goal is to see if this package improves sleep quality, reduces fatigue, a…

This study is testing whether smartphone apps can help people quit smoking, especially those who also experience symptoms of depression. Researchers are comparing two different apps over 8 weeks to see which one is more helpful for improving mood, increasing activity, and support…

This study is testing whether acupuncture can prevent severe dry mouth, a common and painful side effect, in people receiving radiation treatment for head and neck cancer. About 435 participants will be randomly assigned to receive one of two different acupuncture approaches or s…

This study is testing if an 'open-label' placebo—a sugar pill that patients know contains no medicine—can help reduce severe fatigue in people with advanced cancer. About 100 participants with significant fatigue were randomly assigned to either start taking the placebo pills rig…

This study is testing whether a yoga program can help cancer patients and their partners feel better during radiation treatment. It will enroll 600 couples where one person has lung, head and neck, or esophageal cancer. Researchers want to see if doing yoga together improves phys…

This study is testing an online meditation and breathing program designed for couples where one person has a brain tumor. The goal is to see if the program is practical and helps improve spiritual well-being, sleep, mood, and overall quality of life for both the patient and their…

This study is testing a mobile health program designed to help women with breast cancer improve their lifestyle habits. The program provides coaching on healthy eating, exercise, stress management, and sleep over several weeks. Researchers want to see if this approach is practica…

This study is testing whether a combination of home-based exercise and a short course of a steroid medication (dexamethasone) can help reduce severe fatigue in people with advanced cancer. The trial involves 99 participants who will be randomly assigned to do exercise with either…

This study is testing whether a drug called anamorelin, combined with a home exercise program and nutritional counseling, can help reduce severe fatigue in people with advanced, incurable solid tumors. Participants take the drug daily for 6 weeks while following the exercise and …

This study is developing and testing a culturally adapted meditation and support program specifically for Black patients with advanced cancer. Researchers will first gather input from patients and caregivers to shape the program, then pilot test it against a standard education pr…

This study tested whether dexamethasone, a common steroid medication, could help control multiple symptoms in patients with advanced cancer. About 132 participants with solid tumors who were experiencing significant symptoms like fatigue, pain, and nausea took either dexamethason…

This study aims to see if a common stimulant medication (methylphenidate) combined with a guided exercise program can reduce severe, cancer-related fatigue. It involves 212 patients with advanced cancer who are receiving a specific type of immunotherapy (anti-PD1) and are struggl…

This study is testing whether a common steroid drug called dexamethasone can help control severe shortness of breath in cancer patients. About 135 participants with cancer and significant breathlessness were randomly assigned to receive either the drug or a placebo for two weeks.…

This study aims to find the best counseling method to help cancer patients quit smoking. It compares a newer therapy (Acceptance and Commitment Therapy) against standard counseling, with both groups also receiving a quit-smoking medication. The goal is to see which approach is mo…

This study is testing whether yoga classes can help improve physical and emotional well-being for people with cervical cancer while they undergo chemotherapy and radiation. Researchers want to see if yoga reduces common treatment side effects like fatigue, anxiety, and pelvic pai…

This study aims to find the best way to calm severe, distressing agitation (delirium) in hospitalized patients with advanced cancer who are receiving comfort-focused care. It compares four different drug strategies for patients whose initial low-dose medication isn't working. The…

This study is testing if giving a second numbing injection a few days after major abdominal cancer surgery helps patients manage pain with fewer opioid painkillers. It compares a single injection to a repeat injection in patients having surgery for a type of abdominal tumor calle…

This study aims to see if two different relaxation programs, involving stretching and breathing exercises, can help improve the physical and emotional well-being of women with breast cancer while they are receiving radiation therapy. About 700 participants are randomly assigned t…

This study is testing whether home-based exercise and diet programs can help endometrial cancer survivors lose weight and improve their health after treatment. Researchers are comparing three different approaches: exercise with strength training, exercise alone, and standard heal…

This study is testing a 16-week home exercise program designed specifically for Hispanic women who have survived breast cancer. Researchers want to find the best ways to encourage regular physical activity in this group. Participants are asked to exercise 3-5 times per week and a…

This study is testing a mindfulness program specially adapted for Latino culture to help patients with advanced cancer and their family caregivers. The program teaches awareness of thoughts and feelings to reduce stress and anxiety. Researchers are checking if the program is prac…

This study is testing whether a non-invasive brain stimulation technique can help patients recover motor skills, like moving an arm or leg, after surgery for a brain tumor. It involves 32 participants who have recently had surgery and will receive 10 sessions of stimulation durin…

This small pilot study is testing if a vibrating device placed on leg muscles can improve walking in young cancer patients. The patients have nerve damage from chemotherapy that makes walking difficult. Researchers will measure if the vibration changes their step timing and check…

This study is testing if a single session of radiation therapy can relieve symptoms like pain and bleeding from advanced gynecologic cancers as effectively as the standard treatment of multiple sessions over two weeks. It involves 28 women whose cancer has spread, aiming to impro…

This study is testing whether combining a stimulant medication (methylphenidate) with a structured exercise program works better than exercise alone to reduce severe, persistent fatigue in men with prostate cancer. It involves about 200 patients who are starting radiation and hor…

This study aims to find the best drug combination to quickly reduce severe confusion and agitation (delirium) in hospitalized patients with advanced cancer who are receiving comfort-focused care. Researchers are comparing a standard drug (haloperidol) given with either a sedative…

This study aims to find the best combination of treatments to reduce severe fatigue in men with prostate cancer who are receiving radiation and hormone therapy. Researchers are testing different mixes of guided exercise, supportive counseling, and a stimulant medication (or a pla…

This study is testing different medication strategies to quickly calm severe, distressing agitation (delirium) in hospitalized patients with advanced cancer. It involves 70 patients whose initial low-dose medication hasn't worked. Researchers are comparing three approaches: incre…

This study is testing whether a yoga program designed for couples can improve quality of life for people with a serious brain tumor (glioma) and their partners. Patients and their caregivers attend yoga sessions together during radiation treatment. The goal is to see if yoga help…

This small pilot study is testing whether a therapy called neurofeedback can help reduce acute pain caused by radiotherapy in patients with head and neck cancer. Neurofeedback uses sensors and software to measure brainwave activity, aiming to teach patients how to modify their ow…

This study is testing a lifestyle support program called 'Watchful Living' for Black and Hispanic men with early-stage prostate cancer who are on active surveillance (watching and waiting) and their partners. The program provides phone coaching on exercise and nutrition over six …

This study is testing whether a structured exercise program and coaching can help pancreatic cancer patients stay stronger and feel better during chemotherapy and radiation before surgery. About 152 participants will be randomly assigned to either receive the exercise program or …

This early study is testing if a drug called tranexamic acid (TXA) can safely reduce blood loss during a major surgery to remove pelvic tumors. The surgery, called a hemipelvectomy, often involves significant bleeding. Researchers will compare blood loss and transfusion needs in …

This study tested whether cancer patients could use a simple meditation app on their own to help manage feelings of anxiety and depression. Researchers enrolled 35 patients at MD Anderson Cancer Center who reported significant distress. Participants either used the meditation app…

This study is testing whether a yoga program done by patients and their caregivers together can improve quality of life and reduce hospital visits. It involves 415 head and neck cancer patients undergoing chemoradiation and their family caregivers. The goal is to see if this supp…

This study is testing whether a short, daily mind-body exercise program delivered through a phone app can help reduce stress and physical symptoms for women newly diagnosed with breast cancer. About 62 participants were randomly assigned to either use the app for 14 days before s…

This study is testing whether a program combining gentle yoga with Christian spirituality is practical and acceptable for improving mental wellbeing in Black adults. The program is designed for people in Northeast Texas who are mostly inactive and sit for long periods. Researcher…

This study is testing whether a meditation-based program can help young adults (ages 18-39) who were recently diagnosed with lymphoma feel better mentally and improve their overall quality of life. Participants are randomly assigned to either a 5-week meditation group or a 5-week…

This small pilot study is testing whether a type of hands-on massage and stretching therapy can safely help head and neck cancer survivors who have long-term swallowing problems and neck stiffness. Participants receive 10 therapy sessions over 6 weeks, followed by daily home exer…

This study is testing two different methods for doctors to prescribe opioid pain medication when patients go home after major abdominal cancer surgery. It aims to find which method provides better pain control while reducing leftover pills and the need for refills. The trial invo…

This study is testing whether adding acupuncture to standard care helps manage pain after major abdominal surgery for cancers like colorectal or pancreatic. About 70 patients will be randomly assigned to receive either daily acupuncture sessions for a week after surgery or usual …

This study aims to find the best way to give intravenous pain medicine to hospitalized cancer patients. Researchers are comparing whether giving the drug hydromorphone quickly over 2 minutes or slowly over 15 minutes provides better pain relief while lowering the risk of patients…

This study is testing which of two numbing medicines works better to reduce chest pain after a specific lung procedure. It involves 80 adults with lung cancer who are having a biopsy and a small tube placed in their chest. Researchers will compare a newer, long-lasting numbing me…

This study is testing whether doing yoga together can help head and neck cancer patients and their family caregivers feel better during radiation therapy. About 236 patient-caregiver pairs will be assigned to either do partner yoga sessions or just fill out questionnaires. Resear…

This study is testing a program called Harmony & Health, which combines yoga with Christian spirituality. The goal is to see if it's a practical and acceptable way to help Black adults who don't get much exercise to become more active and sit less. Researchers are checking if the…

This study is testing whether a simple daily routine of breathing exercises and meditation can help healthcare workers manage stress and improve lung health during the COVID-19 pandemic. It involves 100 workers from MD Anderson Cancer Center who will practice the techniques for 2…

This study is testing whether a drug called ruxolitinib can help reduce severe fatigue in people with chronic lymphocytic leukemia (CLL) who are not yet receiving standard anti-cancer therapy. About 10 participants will take the pill twice daily for up to two years. The main goal…

This study is testing a lifestyle program designed for African American men who have finished treatment for prostate cancer and their spouses or partners. The goal is to see if working together as a couple can help improve quality of life, increase physical activity, and encourag…

This study is testing an online support program designed to help women with lung cancer feel better emotionally and manage their symptoms. Participants are assigned to either a group learning mindfulness and coping skills or a group receiving educational information about lung ca…

This study is testing a procedure called cordotomy to see if it can reduce severe pain in people with advanced cancer when other pain treatments haven't worked. Doctors use a needle guided by a CT scan to interrupt pain signals in the spinal cord. The goal is to see if this provi…

This study is testing whether a safe, home-based strength training program delivered via video calls can help people with pancreatic cancer. It aims to see if this approach helps patients maintain muscle, strength, and quality of life while they are receiving chemotherapy or reco…

This small pilot study is testing whether smartphone apps can help people quit smoking. Researchers are comparing a positive psychology skills app to a simple breathing relaxation app. All participants are also receiving standard smoking cessation treatment from a clinic. The mai…

This study is testing whether a supervised exercise and diet education program can help cancer survivors who have developed heart failure. Researchers are comparing this program to standard care to see if it improves symptoms and quality of life. The study involves 85 participant…

This study is testing whether a brief writing program, designed specifically for Chinese immigrant culture, can help improve the quality of life and reduce stress for women who have survived breast cancer. Researchers are comparing three different types of writing exercises to se…

This study is testing whether the herbal supplement ginseng can help reduce fatigue and improve other symptoms like mood, depression, and anxiety in people with advanced cancer. About 165 participants with cancer and significant daily fatigue will take either ginseng capsules or …

This study is testing whether a structured program of exercise and weight management can help reduce feelings of fatigue in people living with chronic lymphocytic leukemia (CLL). Researchers at MD Anderson Cancer Center are enrolling 30 adult CLL patients to follow a diet and exe…

This study is testing whether a medication called anamorelin can help improve appetite and prevent weight loss in people with advanced lung cancer who have poor appetite. Researchers will compare anamorelin against a placebo (inactive pill) in 25 patients over 9 weeks. The study …

This study aims to find a quick way to spot depression in women with ovarian, peritoneal, or fallopian tube cancer. It also compares a 10-week phone counseling program with standard care to see which better improves patients' quality of life. Participants answer questionnaires an…

This study is testing whether massage therapy can help reduce nerve problems caused by chemotherapy. Researchers are comparing different massage schedules and locations to see what works best for easing symptoms like pain, numbness, and tingling in the legs. The goal is to improv…

This study is testing whether a home-based exercise program is practical and helpful for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants follow a walking and strength training plan during their treatment. The main goal is to see …

This study is testing whether coaching patients in a specific breathing technique helps them take larger, more consistent breaths during breast cancer radiation treatment. It aims to see if this reduces patient anxiety and helps protect healthy organs from radiation. The study is…

This study is testing whether a type of talk therapy, delivered over the phone, can help patients with acute myeloid leukemia (AML) or lymphoma manage severe, long-lasting cancer-related fatigue. The therapy focuses on teaching patients skills to change unhelpful thoughts and beh…

This study is testing whether a drug called mirtazapine, commonly used for depression, can help improve poor appetite and weight loss in people with advanced cancer. About 98 participants were randomly assigned to receive either mirtazapine or a placebo pill for two weeks, with r…

This study is testing whether a non-invasive brain training technique called neurofeedback can help people manage chronic nerve pain caused by chemotherapy. Participants with breast cancer who have had this pain for at least three months will use a computer program that gives fee…

This study is testing if fast-acting opioid medications, normally used for pain, can help control the distressing shortness of breath cancer patients feel during physical activity. It will compare two opioids (fentanyl and morphine) against a placebo in 150 patients. The main goa…

This study is testing whether a non-invasive brain training technique called neurofeedback can help reduce pain caused by chemotherapy nerve damage. 80 patients who have had chemotherapy and experience lasting nerve pain will be randomly assigned to either receive the brain train…

This study is exploring whether weighted blankets can help improve sleep for adults with blood cancers like leukemia or lymphoma. Researchers are testing if these heavier blankets, which provide gentle pressure, are practical and safe to use in an outpatient setting and if they m…

This study is testing two different non-drug approaches to help head and neck cancer patients manage their pain with fewer opioid medications. It compares standard care against specialized counseling and a brain-training technique called neurofeedback. The goal is to see if these…

This study tests whether weekly phone counseling sessions can help reduce depression in people undergoing radiation treatment for head and neck cancer. Researchers want to see if easing depression helps patients stick better to important swallowing exercises and dental care routi…

This study is testing whether learning self-hypnosis before surgery helps patients with gynecologic cancers feel less pain and use fewer opioid painkillers during recovery. 152 participants are randomly assigned to receive either standard post-surgery care or standard care plus a…

This study aims to find out if repeated MRI brain scans and blood tests can predict changes in memory and thinking skills that sometimes happen after radiation treatment for brain tumors. Researchers will follow 9 adult patients receiving brain radiation, tracking their scans, bl…

This study aims to understand how well a hospital-at-home program works for cancer patients. Researchers will follow 40 patients who receive hospital-level care in their homes instead of staying in the hospital. The goal is to learn about patient experiences and determine if this…

This study aims to identify biological markers in tumors that can predict which patients with advanced solid cancers will respond to immunotherapy. Researchers will treat 16 patients with the immunotherapy drug nivolumab and analyze their tumor tissue and blood samples. The goal …

This study aims to improve conversations between doctors, older cancer patients, and their caregivers. Researchers are testing a special health assessment tool to help doctors better address age-related concerns when discussing chemotherapy. The goal is to see if using this tool …

This study aims to identify why some people develop bladder cancer while others don't, focusing on how genetics and lifestyle factors like smoking interact. Researchers are comparing over 6,000 people with and without bladder cancer to measure genetic differences and tobacco-rela…

This study aims to understand the preferences of advanced cancer patients and their caregivers regarding where they wait during outpatient palliative care visits. Researchers want to know if patients and caregivers prefer to go directly to an exam room or wait in a common waiting…

This study aims to learn more about how brain and cervical cancers work by using two types of advanced scans (PET and MRI) together. Researchers want to see how oxygen levels and blood flow inside these tumors relate to each other and to features seen under a microscope. The stud…

This study is testing whether it's practical to track daily steps in people with newly diagnosed brain tumors (glioma) during their radiation therapy. Researchers want to see if patients will consistently wear either a basic pedometer or a Fitbit device for 6 weeks. The goal is t…

This study is testing whether 3D printed models of the breast help breast cancer patients make better decisions about their surgery. Researchers are comparing patients who receive 3D printed models against those who receive traditional 2D imaging scans. The goal is to see if the …

This study is testing whether a special type of CT scan can help doctors see if cancer drugs are working sooner. The scan measures blood flow to kidney cancer tumors. About 120 patients with advanced kidney cancer will get these scans before and after starting drug treatment to s…

This study is testing a digital tool called an 'oncology dashboard' that shows sarcoma patients and their doctors visual information about how their cancer is responding to treatment. Researchers want to see if using this dashboard helps patients better understand their disease a…

This study aims to understand the recovery process for women who have a major surgery called pelvic exenteration to treat gynecologic cancers. Researchers are observing 79 women to see which surgical techniques lead to fewer complications and better long-term quality of life. The…

This study aims to understand why some children who survive cancer have trouble getting occupational and physical therapy, which can be crucial for recovery. Researchers are interviewing healthcare administrators, doctors, and therapists to identify the specific barriers that lim…

This study is testing whether it's practical for men with intermediate-risk prostate cancer to follow a strict Mediterranean diet for four weeks before their scheduled surgery. The main goal is to see if patients can stick to the diet and to measure how it affects their body chem…

This study aims to understand the lifestyle, emotional, and social factors in the lives of women who have survived advanced ovarian cancer for at least seven years. Researchers will collect information through questionnaires and interviews about diet, exercise, stress, and social…

This study is a survey to understand what high-risk patients and their caregivers think about being prescribed naloxone spray, a medication that can reverse an opioid overdose. Researchers want to learn if people see it as helpful and what might stop them from wanting it. The goa…

This study aims to understand the symptoms patients experience after finishing radiation or chemoradiation for throat cancer. Researchers are asking 77 patients to regularly complete short surveys about their symptoms for several weeks. The goal is to use this information to crea…

This study is testing a symptom questionnaire designed specifically for teenagers with cancer. Researchers are interviewing 13-17 year old cancer patients to see if the questionnaire accurately captures their experiences with pain, fatigue, and other symptoms. The goal is to crea…

This study is testing whether educational videos can help people better understand hereditary cancers that run in families. It involves 43 adult patients who have specific cancer-related gene mutations and receive care at a Houston hospital. Researchers want to see if watching th…

This study is testing whether it's practical to use a Fitbit activity tracker and a continuous glucose monitor together to track daily exercise patterns. It involves 35 adults who are either cancer survivors or at risk for diabetes but do not have diabetes. The main goal is to se…

This early study is testing whether two advanced imaging scans can predict how well chemotherapy will work for patients with triple-negative breast cancer before they have surgery. The goal is to see if these scans can identify which patients are likely to respond to treatment. R…

This study is looking at what happens when older smokers at high risk for lung cancer switch from regular cigarettes to e-cigarettes. Researchers are measuring changes in smoking habits and certain health markers in the blood over 26 weeks. The goal is to gather information to he…

This study aims to understand the worries parents have about giving opioid pain medication to their children with cancer. Researchers are surveying 110 parents to learn why some might hesitate to use these strong pain relievers, even when their child is hurting. The information w…

This study is creating a registry to collect health information from patients with MEN1 or MEN2 syndromes and their family members. The goal is to build a detailed database to help researchers better understand these rare genetic conditions. Participants complete questionnaires a…

This study aims to understand why adults who had cancer surgery are afraid to take their prescribed opioid pain medication after going home. Researchers will interview 50 patients from MD Anderson Cancer Center who were sent home with opioid prescriptions. The goal is to identify…

This study aims to understand how different breast cancer surgery decisions affect patients' emotional well-being and satisfaction over time. Researchers are following 345 women with early-stage breast cancer, surveying them before surgery and at several points afterward. The goa…

This study aims to understand what influences how often patients use a special breathing device after their voice box is surgically removed due to throat cancer. Researchers will observe 130 adults who use the ProvoxLife HME, a single-use device that warms and moistens air enteri…

This study is testing whether advanced imaging scans (PET/MR, PET/CT, and whole-body MRI) can detect leukemia that has spread outside the bone marrow in newly diagnosed acute myeloid leukemia patients. Researchers want to see how often this hidden leukemia occurs and whether find…

This early study is testing a new type of PET-CT scan that uses a special tracer to measure oxygen levels inside solid tumors. The goal is to see if this scan is reliable and safe, and to find the best timing for it. Doctors hope that mapping a tumor's oxygen can help them plan m…

This study is testing two different information sheets to see which one helps patients with advanced cancer and their caregivers communicate better with their doctors. It involves 207 patients, their caregivers, and their palliative care physicians. The goal is to see if a specif…

This study uses brain wave monitoring to understand if cancer patients who appear completely unresponsive near the end of life can still hear or understand words. Researchers will measure brain activity in response to speech and other stimuli in 30 patients. The goal is to provid…

This study aims to understand how treatment affects the daily lives and well-being of people with recurrent rectal cancer. Researchers will ask 116 participants to complete questionnaires about their symptoms, expectations, and quality of life every six months for up to five year…

This study aims to understand what it's like for patients to undergo groin lymph node surgery for penile cancer. Researchers will interview 20 men who had this surgery at least 6 months ago to learn about their experiences and decision-making. The goal is to identify ways to impr…

This study aims to understand if changes in seizure frequency can serve as an early sign of how well a brain tumor is responding to treatment. It involves 100 adults with low-grade glioma who have a history of seizures. Participants complete a short survey about their seizures at…

This study aims to create educational materials to help people understand and make informed decisions about new multi-cancer early detection blood tests. Researchers will gather input from 150 adults through focus groups and surveys to learn what information people need. The goal…

This study aims to understand the financial stress cancer patients experience and what personal and social factors help them cope. Researchers are surveying 625 recently diagnosed patients to learn how their confidence, support networks, and financial knowledge relate to this str…

This study aims to test a new type of MRI scan that uses a special contrast agent to see if it can measure how aggressive an ovarian cancer might be before surgery. It will involve 30 participants, including people at high risk for ovarian cancer and those already suspected of ha…

This study aims to understand the information needs of women aged 65 and older with early-stage breast cancer who are deciding whether to have chemotherapy before or after surgery. Researchers are interviewing patients and doctors to develop a tailored decision support tool. The …

This early study is testing if a drug called adavosertib, given before surgery, can affect the DNA of tumors in patients with advanced ovarian, fallopian tube, or primary peritoneal cancer. The main goal is to learn how the drug changes the cancer cells at a molecular level, whic…

This study aims to understand how the COVID-19 pandemic affected the well-being and quality of life of cancer patients and survivors. Researchers are surveying over 13,000 patients about their pandemic experiences, including health impacts, financial stress, and emotional challen…

This study aims to understand cancer patients' preferences and experiences when using marijuana products (THC or CBD) alongside prescription opioids for pain. Researchers are surveying 200 patients with cancer-related pain in Texas and Arizona to learn which combination they find…

This study is testing a non-invasive brain mapping tool called nTMS to see if it helps doctors plan radiation treatment for brain tumors more safely. It involves 22 adults who have already had radiation for tumors near the brain's movement control area. The goal is to see if this…

This study aims to find out if a molecular test can predict whether low-risk endometrial cancer will return after a patient's surgery. Researchers are studying 518 patients who are scheduled for a hysterectomy. They will analyze tissue and blood samples to see if certain markers …

This study aims to understand which types of health messages are most effective at helping smokers consider quitting. Researchers tested different message styles—fact-based vs. emotional, and positive vs. negative framing—on nearly 500 adult smokers. The goal is to learn how a pe…

This study is testing a special website designed to help young women recently diagnosed with cancer make decisions about preserving their fertility. Cancer treatments can sometimes affect a woman's ability to have children later, and this tool provides information to help them un…

This study aims to understand how rectal cancer surgery affects patients' quality of life over time. Researchers will follow 430 patients for up to 5 years after their surgery, asking them to complete questionnaires about their daily experiences. The goal is to gather information…

This study is exploring whether eating a diet high in fiber and prebiotic foods can change the bacteria in your gut and improve how well your body responds to the seasonal flu vaccine. Researchers are enrolling 31 healthy adults from MD Anderson Cancer Center to follow a specific…

This study aims to understand how often patients develop chronic opioid use or related problems after surgery for head and neck cancer. Researchers will follow 125 patients, asking them to complete questionnaires before and after their surgery to track pain, medication use, and p…

This study is testing whether a quick, electronic brain function test works as well as traditional paper tests for patients having liver surgery. Researchers want to see if the electronic version is easier and faster to complete. The goal is to find better ways to screen for thin…

This study aims to understand how patients with cancer or COVID-19 perceive their doctor's empathy. Researchers are comparing two visit types: in-person where the doctor wears full protective equipment (PPE) versus a video call where the doctor does not. The goal is to learn whic…

This study aims to understand if tiny molecules in the blood, called miRNAs, change when a person has sepsis (a severe bloodstream infection) or after major surgery. Researchers are collecting blood samples from 150 people who either have sepsis or are having surgery to see if th…

This study is testing a quick, non-invasive body scan to measure muscle and fat in people with head and neck cancer who are getting radiation therapy. The goal is to see if this scan is as accurate as a CT scan for tracking changes in body composition. Researchers hope this infor…

This study is testing a new program to help family members of people with hereditary cancer get genetic testing. The program includes a website and a personal guide. Researchers want to see if this approach makes it easier for families to understand and act on their genetic cance…

This study is testing a secure website designed to help families with a known inherited cancer risk. The program helps the person who had genetic testing share their results and relevant health history with their at-risk relatives. The goal is to improve communication within fami…

This study aims to understand how common and severe financial distress is for people with advanced cancer. Researchers are asking 141 patients to complete short surveys about their financial situation, symptoms, and quality of life. The goal is to learn how the high cost of cance…

This study aims to learn if taking extra MRI scans and blood tests during radiation treatment can help doctors predict how a head and neck tumor will change. Researchers will track tumor size and look for biomarkers in the blood of about 80 cancer patients and 20 healthy voluntee…

This study aims to understand how often advanced cancer patients experience severe weight loss and loss of appetite, a condition called cachexia. Researchers are also measuring the emotional and psychological stress this causes for both the patients and their primary family careg…

This study aims to learn how the COVID-19 pandemic affected the quality of life of cancer patients who also have nerve pain (neuropathy). Researchers are surveying 274 patients who were in previous studies to see if their pain, anxiety, and daily life were impacted. They also wan…

This study aims to understand if the types of bacteria in your gut and what you eat can influence how well your body responds to the flu vaccine. Researchers are enrolling adults who are scheduled to get their annual flu shot. Participants will provide stool and blood samples and…

This study is testing whether performing MRI scans while patients are in their exact radiation treatment position improves the planning and delivery of targeted spine radiation therapy. It involves 21 adult cancer patients with tumors that have spread to the spine. The goal is to…

This study aimed to understand the types and severity of sleep problems experienced by patients with gastrointestinal cancers before and after their surgery. Researchers planned to have patients fill out sleep questionnaires daily while in the hospital and wear activity trackers …

This study aimed to understand why some women might want to receive their screening mammogram results immediately during their appointment, instead of waiting days for a report. Researchers planned to survey women aged 30 and older who were scheduled for a mammogram at specific c…

This study aims to understand the daily ups and downs of stress, social support, and healthy habits like exercise and diet in Black men who have survived prostate cancer and their partners. Researchers are observing how couples cope with stress together and how that affects their…

This study observes melanoma survivors who have completed surgery and are receiving immunotherapy drugs to prevent cancer return. Researchers follow 126 patients for two years to track side effects, symptoms like fatigue and depression, and quality of life. The goal is to underst…

This study aims to learn if tiny pieces of cancer floating in the blood can help doctors understand how rectal cancer responds to treatment. Researchers are collecting blood samples from 341 patients with rectal cancer and some healthy volunteers to track these 'circulating tumor…

This study is testing whether people can reliably collect their own health data at home. Researchers want to see if methods like step counters, simple fitness tests, and questionnaires on a handheld device work well outside a clinic. The goal is to gather information to help desi…

This study aims to understand if cancer patients and their rehabilitation doctors have different expectations about recovery after short-term inpatient rehab. Researchers will compare questionnaires from 133 adult cancer patients and their doctors about how well patients will per…

This study aims to understand how people with advanced cancer think about and plan for what happens to their social media accounts (like Facebook or Instagram) after they die. Researchers surveyed 117 patients in a supportive care clinic to learn if they've discussed this with fa…

This study aims to find the best way to help women understand their genetic cancer risk with less stress. It compares watching an online educational video alone to combining it with phone counseling sessions. The goal is to see which method helps participants feel less distressed…

This study aims to understand how common pelvic floor problems are and how they affect quality of life in women who have been treated for uterine cancer. Researchers are comparing survivors who had different treatments (like surgery with or without radiation) to a group of women …

This study aims to understand why colorectal cancer is increasingly affecting younger adults by comparing genetic and lifestyle factors between patients diagnosed before age 50 and those diagnosed later. Researchers will analyze DNA from 818 patients and their family members to i…

This study aims to understand if low testosterone levels might increase a person's risk of developing dementia, depression, or anxiety. Researchers will analyze existing genetic and health data from large public biobanks, not recruit new participants. The goal is to gather knowle…

This study aims to understand how the COVID-19 pandemic impacted the well-being and quality of life of cancer patients, regardless of whether they got COVID-19. Over 1,200 former participants from prior behavioral studies completed a 35-45 minute online survey about their pandemi…

This study is testing whether analyzing the genetic makeup of breast tumors can help predict which standard treatments will work best for individual patients. Researchers are enrolling 1,100 people with early-stage breast cancer to see if genetic testing can accurately identify t…

This study aims to understand how a common antibiotic given right before surgery affects the community of bacteria in the gut (the microbiome) of patients with early-stage skin cancer (melanoma). Researchers will compare patients who receive the antibiotic to those who do not, ch…

This study aims to understand what primary care doctors and Hispanic patients know and think about non-alcoholic fatty liver disease (NAFLD). Researchers are using short surveys and interviews with 17 participants to learn about their perspectives on diagnosis, treatment, and man…

This study aims to understand how cancer patients use cannabis and CBD products. Researchers are surveying 100 patients at a pain clinic to learn how often they use it, why they use it (like for pain or other symptoms), and where they get their information. The goal is to gather …

This study is testing a new type of MRI scan that uses a special inhaled gas to see if it can predict which lung cancer patients will develop serious lung inflammation from radiation therapy. Researchers will scan patients before, during, and after their radiation treatment to lo…

This study is testing a new computer app designed to help breast cancer patients make more informed decisions about breast reconstruction surgery. The app shows patients personalized images of what different reconstruction options might look like for their own body. Researchers w…

This study aims to understand what cancer patients and their radiation doctors think about using video calls for appointments. Researchers are surveying 200 people who have already had a telemedicine visit for cancer care. The goal is to learn about satisfaction, identify challen…

This study is testing whether advanced molecular analysis of a patient's lymphoma can help guide treatment decisions. Researchers will enroll 111 adults with diffuse large B-cell lymphoma to see how quickly test results can be returned and whether they reveal treatment options. T…

This study aimed to gather information to help design future 'hospital at home' programs for cancer patients with fever and low white blood cell counts. Researchers planned to review medical records to see how often these patients had serious complications and what treatments the…

This study aims to collect and analyze medical information from 450 patients with head and neck cancer who have received proton therapy. By reviewing patient records and questionnaires, researchers hope to better understand the long-term survival rates and side effects of this tr…

This study aims to find the best way to spot malnutrition in older adults with cancer. Researchers will test four different screening methods to see which one best predicts a patient's risk of dying or needing unplanned hospital care over the next year. The goal is to improve how…

This study is testing whether regular virtual team meetings can help cancer imaging specialists feel less burned out and more connected to their colleagues. Researchers want to see if this telementoring program is practical and if it improves doctors' well-being and job satisfact…

This study aims to understand how the body's immune system responds to leukemia tumors after they receive standard low-dose radiation treatment. Researchers will take small tissue samples and blood from about 10 adult patients with a type of blood cancer called acute myeloid leuk…

This study aims to understand why some adults with advanced cancer who are prescribed opioid pain medication still experience pain and may be hesitant to take their medication. Researchers are exploring fears about opioids and how these fears relate to anxiety, depression, and pa…

This study is a survey designed to understand the experiences of women who have survived breast or gynecological cancers when it comes to family planning and fertility. Researchers are asking over 1,400 survivors about their decisions, challenges, and use of fertility services af…

This study aims to understand how the physical properties of skin after mastectomy might predict risks during breast reconstruction surgery. Researchers will collect and analyze tissue samples from 140 women undergoing standard implant exchange procedures. The goal is to gather k…