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Could a hormonal IUD replace surgery for some uterine cancers?

NCT ID NCT02397083

Ongoing Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a hormonal intrauterine device (IUD) alone or combined with the drug everolimus can treat precancerous changes or very early-stage endometrial cancer. About 100 women with these conditions will receive the IUD, and some will also take everolimus if the IUD alone doesn't work. The goal is to control or shrink the abnormal cells, potentially avoiding more invasive treatments like surgery.

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Conditions

The condition(s) this trial relates to.

atypical endometrial hyperplasia complex endometrial hyperplasia endometrial endometrioid adenocarcinoma Endometrial Hyperplasia stage I endometrioid carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL ENDOMETRIAL HYPERPLASIA FIGO GRADE 1 ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA FIGO GRADE 2 ENDOMETRIAL ENDOMETRIOID ADENOCARCINOMA

Contacts and locations

Locations

  • Cooper Hospital University Medical Center

    Camden, New Jersey, 08103, United States

  • Covenant HealthCare Mackinaw

    Saginaw, Michigan, 48604, United States

  • Lyndon Baines Johnson General Hospital

    Houston, Texas, 77026-1967, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • MD Anderson Cancer Center at Cooper-Voorhees

    Voorhees Township, New Jersey, 08043, United States

  • MD Anderson League City

    League City, Texas, 77573, United States

  • MD Anderson West Houston

    Houston, Texas, 77079, United States

  • MD Anderson in Sugar Land

    Sugar Land, Texas, 77478, United States

  • MD Anderson in The Woodlands

    Conroe, Texas, 77384, United States

  • McKee Medical Center

    Loveland, Colorado, 80539, United States

  • Memorial Hermann Memorial City Medical Center

    Houston, Texas, 77024, United States

  • North Colorado Medical Center

    Greeley, Colorado, 80631, United States

  • Northwell Health

    New Hyde Park, New York, 11042, United States

  • OhioHealth Mansfield Hospital

    Mansfield, Ohio, 44903, United States

  • Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • The Woman's Hospital of Texas

    Houston, Texas, 77054, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia, 22908, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.