Nanoparticles + radiation: new hope against tough pancreatic cancer?
NCT ID NCT04484909
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new approach for people with pancreatic cancer that cannot be removed right away. Tiny nanoparticles called NBTXR3 are injected directly into the tumor and then activated by radiation therapy. The goal is to find a safe dose and see if this combination can help control the disease. The study involves 24 participants and is led by M.D. Anderson Cancer Center.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NBTXR3 nanoparticles (hafnium oxide) activated by radiation therapy
- What this could lead to
- If it works, this could lead to a new way to shrink pancreatic tumors and make them easier to remove surgically, potentially improving survival.
- What could go wrong
- This is a very early Phase 1 trial with only 24 people, so safety and effectiveness are not yet proven. The nanoparticles are injected directly into the pancreas, which carries risks like bleeding or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BORDERLINE RESECTABLE PANCREATIC ADENOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gene test may guide smarter chemo for pancreatic cancer
- Four-Drug cocktail aims to shrink pancreatic tumors before surgery
- Could a Decades-Old parasite drug help fight pancreatic cancer?
- New drug combo aims to shrink Hard-to-Treat pancreatic and ovarian tumors
- Triple threat against pancreatic cancer: radiation, immunotherapy, and chemotherapy combined
- Can a tailored web portal help pancreatic cancer patients exercise and eat better during chemotherapy?