Two-Drug combo shows promise for Hard-to-Treat uterine cancer
NCT ID NCT01068249
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II study tests whether the combination of letrozole (Femara) and everolimus (Afinitor) can help control advanced or recurrent endometrial cancer. The trial enrolled 42 participants whose cancer had progressed or returned. Researchers are measuring how many patients respond to treatment and how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- letrozole and everolimus
- What this could lead to
- If this works, it could offer a new treatment option to control advanced or recurrent endometrial cancer without chemotherapy.
- What could go wrong
- This is a small, early-phase trial with only 42 people. The combination may not work better than existing treatments, and side effects from the drugs could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Morristown Memorial Hospital, Women's Cancer Center
Morristown, New Jersey, 07962, United States
-
University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A safer first cut? trial tests two laparoscopic entry points for endometrial cancer surgery
- Could a common Weight-Loss drug help hormone therapy work better for young women with endometrial cancer?
- New biologic drug DBC-664 takes aim at Hard-to-Treat cancers
- New imaging tool could help surgeons detect hidden cancer cells during surgery
- Could a simple diet replace an enema before endometrial cancer surgery?
- Proton beam therapy plus chemo aims to improve Post-Surgery treatment for advanced endometrial cancer