Experimental pill added to chemo for tough pancreatic cancer

NCT ID NCT05497778

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase trial is testing whether adding an experimental drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe and tolerable for people with advanced pancreatic cancer. The study involves 19 participants and is being run by M.D. Anderson Cancer Center. The main goal is to check for side effects, but researchers will also look at whether the combination might help control the cancer.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
IM156 (an experimental drug taken by mouth) plus gemcitabine and nab-paclitaxel (standard chemotherapy drugs given by IV)
What this could lead to
If it works, this could point toward a new combination treatment for advanced pancreatic cancer that is safe and may help control the disease.
What could go wrong
This is a very early Phase 1 trial with only 19 people, focused on safety. It is too small and early to know if the combination actually helps patients live longer or better.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

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