New combo therapy aims to tackle returning lymphoma
NCT ID NCT02446457
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial is testing whether combining rituximab and pembrolizumab, with or without lenalidomide, can help patients with follicular lymphoma or diffuse large B-cell lymphoma that has returned after previous treatment. The study enrolls 53 participants and measures how many patients achieve a complete or partial response. The goal is to find a more effective treatment for these relapsed cancers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rituximab, pembrolizumab, and lenalidomide
What this could lead to
If successful, this combination could offer a new treatment option for patients with relapsed follicular lymphoma or diffuse large B-cell lymphoma, potentially improving response rates.
What could go wrong
This is an early-phase trial with a small number of participants (53). The treatment may cause side effects, and not all patients may respond. Results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States