New drug combo shows promise in saving voice boxes of cancer patients

NCT ID NCT04030455

First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 21 times

Summary

This study tested a treatment that combines two chemotherapy drugs (cisplatin and docetaxel) with an immunotherapy drug (pembrolizumab) in 28 patients with stage II or III laryngeal cancer. The goal was to see if this approach could control the cancer and allow patients to keep their larynx (voice box). After four cycles, 75% of patients had no cancer detectable in tissue samples. The treatment aims to control the disease, not cure it, and patients may need ongoing monitoring or additional therapy.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.