New drug cocktail shows promise in larynx cancer without surgery

NCT ID NCT04030455

First seen Nov 01, 2025 · Last updated Jun 13, 2026 · Updated 23 times

Summary

This study tested a combination of two chemotherapy drugs (cisplatin and docetaxel) plus an immunotherapy drug (pembrolizumab) in 28 patients with stage II or III laryngeal cancer. The goal was to see if this drug-only approach could control the cancer and avoid the need for surgery or radiation, preserving the voice box. Early results showed a high rate of tumor shrinkage or disappearance, but long-term disease control and side effects are still being evaluated.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

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