Spine radiation showdown: one big blast or three small doses?
NCT ID NCT03028337
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a single large dose of spine radiosurgery works better than three smaller doses for people whose spinal tumors have come back after previous radiation. About 80 adults with solid tumors that spread to the spine will be randomly assigned to one of the two radiation schedules. Researchers will track how long it takes for the tumor to grow back, and whether patients have less pain and better quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Spine radiosurgery (radiation therapy)
What this could lead to
If successful, this could show that a single high dose of radiation is as good as or better than multiple smaller doses for controlling spinal tumors and easing pain.
What could go wrong
This is a small, early-phase trial with only 80 participants, so results may not apply to everyone. Radiation to the spine carries risks like nerve damage or fractures.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States