Radiation boost may stall spread in early metastatic cancers
NCT ID NCT03599765
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether adding targeted radiation (local consolidative therapy) to standard systemic therapy can better control cancer that has spread to a few spots (oligometastatic disease). About 380 adults with solid tumors and up to 5 metastases are randomly assigned to receive standard therapy alone or with radiation. Researchers track side effects, cancer progression, new metastases, and survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Local Consolidative Therapy (radiation)
- What this could lead to
- If successful, this could show that adding targeted radiation to standard treatment helps delay cancer progression and improves survival for people with limited metastatic disease.
- What could go wrong
- This is a mid-stage trial with 380 participants, so results are not yet conclusive. The benefit may be small or not apply to all cancer types, and radiation carries risks like fatigue or local side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Baptist Health Medical Center
Little Rock, Arkansas, 72205, United States
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Community Health Center
Coldwater, Michigan, 49036, United States
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Cooper Hospital University Medical Center
Camden, New Jersey, 08103, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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MD Anderson League City
Nassau Bay, Texas, 77058, United States
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MD Anderson in Katy
Houston, Texas, 77094, United States
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MD Anderson in Sugar Land
Sugar Land, Texas, 77478, United States
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MD Anderson in The Woodlands
The Woodlands, Texas, 77384, United States
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OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903, United States
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Queen's Medical Center
Honolulu, Hawaii, 96813, United States
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University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229, United States
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