Could donor stem cells repair hearts damaged by chemo?
NCT ID NCT02962661
First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 5 times
Summary
This early-stage trial is testing whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 participants will either receive standard care alone or standard care plus stem cells given through a vein or directly into the heart. The main goal is to check for side effects and see if the stem cells improve heart function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- donor bone marrow derived mesenchymal stem cells
- What this could lead to
- If it works, this could point toward a new treatment for heart failure caused by chemotherapy, potentially improving heart function and quality of life.
- What could go wrong
- This is a very early phase 1 trial with only 72 participants, so it is not yet proven to work. There may be side effects from the stem cell infusions or injections.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ANTHRACYCLINE-ASSOCIATED CARDIOMYOPATHY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Digital nurse companion: could an app ease the burden of chronic illness?
- Could continuing a common heart drug before surgery save lives?
- Poles apart? nordic walking may outpace standard rehab for heart failure
- Could a gentler tug on the Heart's reins spark recovery?
- Can slow breathing soothe a failing heart?
- Can shedding pounds reboot the Heart's exercise engine?