New cocktail of drugs and radiation aims to boost stomach cancer treatment before surgery
NCT ID NCT03776487
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether giving a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with chemotherapy and radiation therapy before surgery can help treat stomach cancer that can be surgically removed. The study includes 32 participants and primarily looks at safety and side effects. The goal is to see if this approach can shrink tumors and improve outcomes without causing too many severe side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab and ipilimumab (immunotherapy drugs), plus chemotherapy (oxaliplatin, fluorouracil) and radiation therapy
- What this could lead to
- If successful, this combination approach could improve outcomes for patients with resectable gastric cancer by shrinking tumors before surgery and reducing recurrence risk.
- What could go wrong
- This is a small, early-phase pilot study (32 participants) focused on safety, not yet proven to work. Side effects from the combination of immunotherapy, chemo, and radiation may be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new drug combo shrink Hard-to-Treat tumors?
- Can immunotherapy outperform chemo after stomach cancer surgery?
- Could a smartphone program supervised by AI boost recovery after stomach cancer surgery?
- Can stomach cancer surgery also tame diabetes?
- Can a modified stomach bypass speed up recovery in advanced gastric cancer?