Can the HPV vaccine protect stem cell transplant patients?

NCT ID NCT03023631

First seen Nov 18, 2025 · Last updated Jun 20, 2026 · Updated 28 times

Summary

This study tests whether the Gardasil 9 vaccine can help stem cell transplant patients build immunity against HPV. About 48 adults who had a stem cell transplant for blood cancer will receive the vaccine. Researchers will measure antibody levels to see if the vaccine works in these patients.

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Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Gardasil 9 (HPV vaccine)

What this could lead to

If successful, this could show that the HPV vaccine works in stem cell transplant patients, helping prevent HPV-related cancers in this vulnerable group.

What could go wrong

This is a small, single-center study (48 people) with no placebo group. The immune response may be weaker in transplant patients, and the vaccine may not prevent infection or cancer long-term.

Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm human papilloma virus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.