Vaccine boosts Chemo-Radiation against cervical cancer in early trial
NCT ID NCT04580771
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether adding a vaccine called PDS0101 to standard chemoradiation is safe and effective for people with advanced cervical cancer. The vaccine trains the immune system to attack HPV-infected tumor cells. About 22 participants will receive the combination, and researchers will monitor side effects and tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PDS0101 (a vaccine that helps the immune system attack HPV-infected cervical cancer cells) combined with cisplatin chemotherapy and radiation therapy
- What this could lead to
- If successful, this combination could offer a more effective treatment for advanced cervical cancer, potentially improving tumor shrinkage and long-term control.
- What could go wrong
- This is a small, early-phase trial (22 participants) focused on safety, not yet proven to work. Side effects from the vaccine, chemo, and radiation could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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