Brain radiation may stop cancer spread in rare bladder cancer

NCT ID NCT00756639

Ongoing Prevention Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether whole brain radiation can lower the chance of brain tumors in people with small cell carcinoma of the urinary tract (including the bladder). The 31 participants have already had chemotherapy and responded well. They receive radiation to the brain for 3 weeks, and are monitored for a year to see if brain metastases develop.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: whole brain radiation (prophylactic cranial irradiation)
What this could lead to: If it works, this could point toward a way to prevent brain metastases in people with this rare bladder cancer.
What could go wrong: This is a small, early-phase trial with only 31 participants, so results may not apply to everyone. The radiation itself can have side effects like memory problems or fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BLADDER CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

adenocarcinoma brain cancer transitional cell carcinoma urinary bladder carcinoma Urinary Bladder Neoplasms urinary bladder small cell neuroendocrine carcinoma metastatic malignant neoplasm in the brain prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLADDER CANCER

Contacts and locations

Locations

University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.