New drug shrinks thyroid tumors before surgery in early trial

NCT ID NCT04759911

First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 25 times

Summary

This study tests whether giving the drug selpercatinib before surgery can shrink thyroid cancers with a specific genetic change (RET alteration). About 30 people with advanced or recurrent thyroid cancer will receive the drug and then have surgery. The goal is to see if the drug helps control the disease and makes surgery more successful.

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Contacts and locations

Locations

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Michigan Health Systems

    Ann Arbor, Michigan, 48109, United States

Conditions

Explore the condition pages connected to this study.