New drug shrinks thyroid tumors before surgery in early trial

NCT ID NCT04759911

First seen Nov 01, 2025 · Last updated Jun 15, 2026 · Updated 33 times

Summary

This study tests whether taking selpercatinib before surgery can shrink thyroid tumors that have a specific genetic change (RET alteration). About 30 people with advanced or recurrent thyroid cancer will receive the drug before their operation. The goal is to make surgery more effective and help control the disease long-term.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Michigan Health Systems

    Ann Arbor, Michigan, 48109, United States

Conditions

Explore the condition pages connected to this study.