M.d. Anderson Cancer Center

This study tested whether using a lower dose of the drug ipilimumab together with pembrolizumab could help control melanoma that had spread to the brain. The trial involved 24 patients with this advanced cancer. Researchers wanted to see if this combination was safe and could shr…

This study tested whether the drug dasatinib could help control several rare blood disorders including leukemia, myelofibrosis, and mastocytosis. Participants took dasatinib pills daily for as long as it helped control their disease. Researchers monitored blood counts and bone ma…

This study tested two different ways of giving immunotherapy drugs (durvalumab and tremelimumab) to women with recurrent ovarian, fallopian tube, or primary peritoneal cancer that had stopped responding to standard platinum-based chemotherapy. The goal was to see if giving the dr…

This early-phase study tested whether giving the drug erlotinib for a few weeks before surgery could help patients with recurrent head and neck cancer. The trial involved 48 participants who were scheduled for surgery and aimed to see how different doses of the drug affected canc…

This early-stage study tested a new drug called pembrolizumab (MK-3475) when given alongside standard chemotherapy and radiation for small cell lung cancer. The main goal was to find a safe dose and understand the side effects of this combination. Researchers also wanted to see i…

This study tested a two-drug combination given before surgery to treat triple-negative breast cancer, a type that can be harder to treat. It involved 37 patients whose cancer did not shrink enough after standard initial chemotherapy. The goal was to see if adding an immunotherapy…

This study tested a new combination treatment for people with colon cancer who had surgery and chemotherapy but still had tiny amounts of cancer left in their blood. The treatment used specially prepared immune cells (CB-NK cells) from donors, given along with the drug cetuximab.…

This study tested an immunotherapy drug called blinatumomab in adults with a type of blood cancer (B-cell acute lymphoblastic leukemia) who were in remission but still had tiny amounts of cancer cells left. The goal was to see if the drug could help the immune system find and des…

This study tested if adding a drug called axitinib to standard hormone-blocking therapy before surgery could better control prostate cancer that had spread to lymph nodes. It involved 73 men who were randomly assigned to receive either the standard therapy alone or the standard t…

This study tested whether a combination of daily aspirin, vitamin D, a low-fat diet, and regular exercise could help prevent colorectal cancer from coming back. It involved 16 patients who had completed their main cancer treatment but still had tiny traces of cancer DNA in their …

This early-stage study tested a new combination of three drugs for people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goals were to find the safest dose of the drug combination and to see if it could shrink tumors. Resea…

This study tested whether adding a targeted drug (panitumumab) to two standard chemotherapy drugs could shrink tumors before surgery in patients with triple-negative breast cancer. The treatment was specifically for patients whose cancer didn't respond well to initial chemotherap…

This study tested an immunotherapy drug called sintilimab for patients with advanced cancer of unknown primary origin (CUP), a rare and difficult-to-treat cancer where the original site is unknown. The trial enrolled 10 patients whose cancer had progressed after standard chemothe…

This study tested whether the immunotherapy drug pembrolizumab could prevent oral cancer in people with high-risk precancerous mouth lesions. Fifteen participants were randomly assigned to either receive the drug or be observed without treatment. The main goal was to see if the d…

This study tested whether combining targeted radiation with immune-boosting drugs could help control advanced cancers that had spread to the lungs or liver. Researchers worked with 51 patients to find safe doses and see if this approach could shrink tumors both where radiation wa…

This study tested whether adding the drug erlotinib to standard chemotherapy helps control head and neck cancer before surgery. Fifty-five patients with operable oral cavity cancer were randomly assigned to receive either the standard chemo combination plus erlotinib or plus a pl…

This early-stage study tested a new combination of drugs for patients with aggressive lymphomas that have come back or not responded to standard treatments. The main goal was to find the safest dose of a drug called olaparib when given with a powerful chemotherapy regimen before …

This study tested whether combining a type of immunotherapy (pembrolizumab) with targeted radiation could help patients whose aggressive non-Hodgkin lymphoma had come back or stopped responding to other treatments. The goal was to see if the combination could shrink tumors and co…

This study tested a two-part treatment for people whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) came back after a donor stem cell transplant. It combined a drug called guadecitabine, which may slow cancer growth, with infusions of the donor's white blood ce…

This study tested whether a daily pill called dasatinib could control Chronic Myelogenous Leukemia (CML) in its early, chronic phase. It involved 150 patients who were newly diagnosed or had minimal prior treatment. The main goal was to see if the drug could achieve a deep reduct…

This study tested whether adding 'off-the-shelf' natural killer (NK) immune cells from a donor could make stem cell transplants more effective for adults with high-risk forms of leukemia. The goal was to see if this combination was safe and could help prevent the cancer from comi…

This early-stage study tested two immunotherapy drugs, nivolumab and ipilimumab, in patients with high-risk or returning acute myeloid leukemia or myelodysplastic syndrome who had already received a donor stem cell transplant. The main goals were to find safe doses and check for …

This study tested whether the drug dasatinib could help control chronic lymphocytic leukemia (CLL), a type of blood cancer. Seventeen patients who had previously received other treatments took dasatinib pills twice daily. Researchers monitored how well the cancer responded and ch…

This study tested a new, packaged form of two standard chemotherapy drugs (CPX-351) for adults newly diagnosed with a fast-growing blood cancer called AML. The patients were older or had other health problems, putting them at high risk of severe side effects from standard treatme…

This study tested a new combination of three cancer drugs for children and young adults whose acute myeloid leukemia (AML) came back or did not respond to standard treatments. The main goal was to find the safest dose and understand the side effects. Researchers hoped this target…

This study tested a new two-part immunotherapy for patients whose Hodgkin or Non-Hodgkin lymphoma has returned or not responded to other treatments. It combined a special antibody (AFM13) with donated immune cells (NK cells) to help the patient's own immune system find and kill c…

This study tested a combination of three drugs—durvalumab, tremelimumab, and selumetinib—for people with advanced or returning non-small cell lung cancer. The goal was to see if using these drugs together could help the immune system fight the cancer and slow its growth better th…

This study tested a new combination of three chemotherapy drugs (uproleselan, cladribine, and low-dose cytarabine) for adults with a specific type of acute myeloid leukemia (AML) that developed after treatment for another blood disorder. The main goals were to find the safest and…

This study tested whether adding a new immunotherapy drug (atezolizumab) to the standard treatment of chemotherapy and radiation could help patients with newly diagnosed glioblastoma, a very aggressive brain cancer. The goal was to see if this combination was safe and if it could…

This study looked back at medical records to see if adding a specific type of antibiotic (aminoglycoside) to standard treatment helps cancer patients with a severe blood infection (sepsis) recover their blood pressure faster. It involved 232 adult cancer patients who developed se…

This early-stage trial tested two oral drugs, vandetanib and everolimus, given together to people with advanced cancer that had spread or stopped responding to standard treatments. The main goals were to find the safest dose of this combination and to understand its side effects.…

This study tested if starting a drug called ibrutinib earlier could better control a type of blood cancer called chronic lymphocytic leukemia (CLL) in patients who are at high risk for the disease getting worse but don't yet have symptoms. The usual approach is to wait until symp…

This study tested whether adding a specific biopsy procedure (EBUS-TBNA) after a standard PET/CT scan could more accurately determine the stage of early lung cancer. It involved 150 patients with early-stage non-small cell lung cancer who were being evaluated for a targeted radia…

This study tested whether a special type of mammogram, which uses a contrast dye injected into the vein, is better at finding all areas of breast cancer in women who were getting a second opinion at a major cancer center. The goal was to see if this method could find cancers that…

This early-stage study tested a personalized vaccine designed to prevent smoldering multiple myeloma from turning into active cancer. Doctors created a custom vaccine from each patient's own blood and bone marrow cells to train their immune system to attack cancer cells. The main…

This study tested a mobile app designed to help breast surgery patients before and after their operation. Researchers wanted to see if the app was easy to use and helpful for providing support and resources. The study involved 60 patients and focused on measuring how satisfied pe…

This study tested if a single, highly precise session of radiation could safely and effectively treat tumors that had spread to the spine. The goal was to relieve pain and control tumor growth in patients with cancer that had metastasized. Researchers used special imaging to guid…

This study tested whether giving a second anesthetic nerve block a few days after pancreatic cancer surgery helps patients manage pain with fewer opioid painkillers. Researchers compared patients who received the standard single nerve block before surgery to those who got a secon…

This study tested whether playing a special augmented reality scavenger hunt game could help children with cancer feel less pain and need fewer opioid painkillers after surgery. Researchers compared the game to a regular non-AR game in 29 children aged 5-15. The goal was to see i…

This study explored whether two simple activities could improve well-being for cancer patients and their caregivers, focusing on people from cultures that value family and community. For four weeks, patients either performed small acts of kindness for their caregiver or wrote the…

This study tested if a gentle electrical stimulation applied to a specific point on the wrist during surgery could help prevent nausea and vomiting afterward. It involved 188 women at high risk for these symptoms who were undergoing breast cancer surgery. Participants were random…

This study aimed to understand if men and women experience switching from regular cigarettes to e-cigarettes differently. Researchers enrolled 169 adult smokers to track their use, preferences, and nicotine dependence symptoms over six weeks. The goal was to gather knowledge abou…

This study aimed to understand what happens when smokers switch to cigarettes with very little nicotine, while also having access to e-cigarettes with different nicotine strengths. Researchers observed 213 daily and occasional smokers to see how this combination affected their cr…

This small, completed study tested whether two new tools could safely measure pressure and stiffness inside solid tumors. Doctors used a tiny catheter and a special ultrasound during scheduled biopsies in 27 patients. The main goal was to see if these measurements are possible an…

This study aimed to understand why Black men in faith-based communities might not get screened for prostate cancer. Researchers held focus groups with 24 Black men to learn about their specific barriers and concerns. The information will be used to create a prostate cancer educat…

This study compared two camera-guided methods for placing breathing tubes in head and neck cancer patients before surgery. Researchers tested whether using one flexible camera scope alone worked as well as using that scope combined with a video laryngoscope. The goal was to find …