Boosting transplants with natural killers: new combo therapy aims to stop blood cancer return

NCT ID NCT05115630

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether adding ready-made natural killer (NK) cells from a donor to a standard stem cell transplant could safely reduce the chance of cancer returning in people with high-risk myeloid cancers like acute myeloid leukemia, myelodysplastic syndrome, and chronic myeloid leukemia. Twenty-four adults aged 18 to 70 received the combination treatment. The goal was to see if this approach improves outcomes without causing graft failure or early death from causes other than relapse.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia chronic myelogenous leukemia, BCR-ABL1 positive Leukemia, Myelogenous, Chronic, BCR-ABL Positive myelodysplastic syndrome Myelodysplastic Syndromes myeloid neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • M D Anderson Caner Center

    Houston, Texas, 77030, United States