M.d. Anderson Cancer Center

This study is testing whether a procedure called radiofrequency ablation (RFA) can help control high calcium levels in people with recurrent parathyroid cancer. It will enroll 20 adults who have had surgery before but now have cancer that has come back in the neck and are not can…

This study is testing whether combining three existing drugs—ruxolitinib, cladribine, and venetoclax—can help control a rare and aggressive form of T-cell leukemia that has returned or not responded to prior treatment. The main goals are to see if the combination is safe and if i…

This study aims to find a safe and effective dose of an oral drug called cladribine when given with two other leukemia medications. It will test this combination in adults with acute myeloid leukemia (AML) who have either newly diagnosed or relapsed disease. The goal is to see if…

This early-stage trial aims to find a safe and effective dose of two oral drugs, olutasidenib and ziftomenib, used together. It is for adults with a hard-to-treat, relapsed form of acute myeloid leukemia (AML) that has two specific genetic mutations (NPM1 and IDH1). The study wil…

This early-phase study aims to control metastatic colorectal cancer by testing personalized drug combinations tailored to each patient's tumor characteristics. Researchers will enroll 100 adults with advanced colon cancer that has spread, using biopsies to identify resistance mar…

This is an early safety study to find a safe dose of an experimental virus therapy called DNX-2401 for advanced melanoma. The study will enroll about 50 adults whose melanoma has spread to the brain or other parts of the body. Doctors will inject the modified virus directly into …

This early-stage study aims to find a safe dose for a new four-drug combination (called TraPIN) in children and young adults whose soft tissue sarcoma has returned. The main goal is to see how well patients tolerate the treatment and to check for side effects. Researchers also ho…

This study tests a new cell therapy for adults with aggressive T-cell blood cancers who are in their first remission. Researchers will give patients specially engineered natural killer (NK) immune cells designed to target cancer, along with chemotherapy. The main goals are to see…

This study is testing if adding targeted local treatments like radiation or surgery to the drug lorlatinib helps people with advanced ALK-positive lung cancer live longer without their cancer getting worse. It will involve about 30 adults who have not taken certain other targeted…

This small pilot study aims to see if a drug called infliximab is safe and can help patients stop needing insulin injections. The patients developed diabetes as a side effect of powerful cancer immunotherapy drugs called checkpoint inhibitors. Researchers want to know if inflixim…

This study is testing whether regularly using a special voice prosthesis called the Provox ActiValve can reduce the number of times patients need to have their voice device replaced each year. The research will involve 48 adults who have had their voice box removed due to cancer …

This study is testing a new, non-surgical procedure called nanosecond pulsed field ablation (nsPFA) to shrink benign thyroid nodules. It will enroll 30 adults who have a large, bothersome nodule causing symptoms like trouble swallowing or a feeling of pressure. Researchers will t…

This early-stage study aims to find a safe and effective dose of two drugs, revumenib and blinatumomab, given together for adults with a specific genetic type of acute lymphoblastic leukemia (ALL). It will enroll about 20 adults, including those newly diagnosed and those whose ca…

This study is testing if adding a drug called glofitamab after standard initial treatment can better control a fast-growing type of blood cancer called mantle cell lymphoma (MCL). It is for adults newly diagnosed with a high-risk form of MCL who have not yet started treatment. Th…

This study is testing a new combination treatment for adults with B-cell non-Hodgkin lymphoma that has come back or stopped responding to other therapies. It combines specially modified natural killer (NK) immune cells from donated umbilical cord blood with two antibody drugs (ep…

This study is testing whether specially modified natural killer (NK) immune cells can help control two types of aggressive lymphoma that haven't responded well to standard treatments. Researchers will give these engineered cells to 100 adults whose lymphoma either didn't respond …

This is an early safety study testing a new treatment for melanoma that has spread to the membranes surrounding the brain and spinal cord. Doctors will collect a patient's own immune cells, grow them to target melanoma, and inject them directly into the spinal fluid. The main goa…

This early-stage trial is testing whether adding an experimental nanoparticle called NBTXR3 to standard radiation therapy can better control advanced lung cancer. It's for up to 40 patients whose cancer cannot be removed by surgery and who are not candidates for chemotherapy. The…

This study is testing a new, non-surgical procedure called nanosecond pulsed field ablation (nsPFA) for treating small thyroid cancers. Doctors will use ultrasound to guide tiny electrical pulses to target and destroy cancer cells in the thyroid. The main goals are to see if this…

This study is testing whether a new drug called sacituzumab tirumotecan can help control an advanced and aggressive form of kidney cancer called SMARCB1-deficient renal medullary carcinoma. It is for adult patients whose cancer has continued to grow despite receiving at least one…

This study is testing whether combining two drugs, dasatinib and ropeginterferon, can help control chronic myeloid leukemia (CML) in newly diagnosed patients. Researchers will enroll about 40 adults to see if this combination is safe and effective at reducing cancer markers in th…

This early-stage study is testing a new treatment for people whose pancreatic cancer has come back or spread. It combines a type of cell therapy, where immune cells are engineered to attack cancer, with a daily pill. The main goals are to see if the treatment is safe and to find …

This study is testing a new catheter system called TriNav for delivering targeted radiation therapy (Y90 radioembolization) to liver tumors. It will compare how well this new system delivers a contrast dye to tumors versus standard catheters, using special CT scans. The main goal…

This study is testing if a new combination of two drugs, given as an injection and a pill, can help control a specific type of aggressive blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). It will involve about 60 adults, either newly diagnos…

This early-stage study is testing the safety of a genetically modified herpes virus (M032) designed to fight a rare and aggressive type of brain tumor called diffuse midline glioma. The virus is injected directly into the tumor during surgery in up to 20 children and adults who h…

This early-phase study aims to find a safe and effective dose of a three-drug combination (avutometinib, defactinib, and everolimus) for people with recurrent endometrial cancer that has specific genetic changes in the RAS pathway. It will enroll about 31 participants who have al…

This study is testing whether giving the drug blinatumomab as an injection under the skin can help control very low levels of leukemia cells and prevent the cancer from coming back. It will involve about 40 adults with B-cell acute lymphoblastic leukemia who are in remission but …

This early-stage study aims to see if a new drug called HC-7366, when combined with standard immunotherapy drugs (nivolumab with or without ipilimumab), can help control advanced clear cell kidney cancer. It will enroll about 35 adults to test the safety of these combinations and…

This early-stage study is testing a new oral drug, revumenib, added to a standard chemotherapy combination for children and young adults with acute leukemia. The first goal is to find the safest, most effective dose. The second goal is to see if this new combination can help cont…

This study is testing whether combining two drugs, zanzalintinib and cemiplimab, can help people with a very aggressive form of thyroid cancer called BRAF wild-type anaplastic thyroid cancer. The main goal is to see if this combination can help patients live longer. It will invol…

This study aims to measure how much radiation from Pluvicto therapy reaches tumors and healthy organs in prostate cancer patients whose kidneys or bone marrow aren't working properly. Researchers will track 25 patients to understand the safety and side effects of this treatment i…

This early-stage study aims to find safe doses of two new drugs, lisaftoclax and pelcitoclax, when combined with a standard chemotherapy called FLAG. It is for adults whose T-cell acute lymphoblastic leukemia (T-ALL) has come back or hasn't responded to previous treatments. The m…

This early-stage study is testing whether combining two drugs works better for people with advanced lung cancer that has a specific genetic change (KRAS G12C) and has stopped responding to previous targeted treatments. The main goal is to check if the combination is safe and tole…

This study is testing whether a personalized immune cell therapy called liso-cel can prevent large B-cell lymphoma from returning. It's for patients who have finished their first round of treatment successfully but still have tiny traces of cancer DNA in their blood. Researchers …

This study is testing a new drug called puxitatug samrotecan (AZD8205) in patients with an aggressive form of a rare salivary gland cancer called adenoid cystic carcinoma that has returned or spread. The main goals are to see if the drug shrinks tumors and is safe for patients. T…

This study aims to see if a combination of two drugs, zanzalintinib and pembrolizumab, can help control the growth of certain advanced or spreading soft-tissue sarcomas. It will enroll about 20 adults with specific sarcoma subtypes who have not had certain prior treatments. The m…

This study is testing whether giving low doses of radiation therapy before a new drug called elranatamab can help the drug work better against a hard-to-treat form of multiple myeloma. It will involve about 34 adults whose cancer has returned or stopped responding to standard tre…

This early-stage trial is testing a new cell therapy for adults with advanced lymphomas or leukemia that has come back or not responded to other treatments. Doctors will give patients specially modified immune cells (called CAR-NK cells) made from donated cord blood, after a shor…

This early-phase trial is testing a new type of treatment for people with colorectal cancer that has spread to the lining of the abdomen. Doctors are giving patients specially modified immune cells, called CAR-NK cells, directly into the abdomen and bloodstream, along with a stan…

This early-stage study is testing the safety and feasibility of a new magnetic tracer, FerroTrace, used alongside a fluorescent dye to help surgeons better identify the lymph nodes most likely to contain cancer during stomach removal surgery. The goal is to improve the accuracy o…

This study aims to see if using a new contrast agent called gadopiclenol during MRI brain scans can help doctors detect leptomeningeal disease (LMD) earlier. LMD is a serious complication where cancer spreads to the lining of the brain and spinal cord. Researchers will test diffe…

This study is testing a handheld pen-like device that analyzes tissue during surgery. The goal is to see if it can quickly and accurately tell the difference between normal tissue, benign nerve tumors (neurofibromas), and a rare, aggressive cancer called MPNST. This could help su…

This study is testing a new type of microscope called DeepDOF. It takes high-quality digital images of cervical tissue samples right after they are collected. The goal is to see if these images can help doctors diagnose cervical cancer and pre-cancer as accurately as standard lab…

This study is testing whether drawing blood directly from veins inside the brain is safe and can provide the same detailed cancer information as traditional surgical biopsies. Researchers will enroll 20 adults with suspected or confirmed high-grade brain tumors who already need a…

This study tests whether performing a special microsurgery called lymphovenous bypass during lymph node removal can prevent lymphedema—a painful, chronic swelling of the arm or leg. Researchers will compare outcomes in 20 melanoma patients who receive the bypass at the time of th…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' can prevent or reduce the severity of nerve damage caused by chemotherapy. It will involve 83 adults with breast, colorectal, or head & neck cancer who are scheduled to receive specific chemothera…

This study is testing whether inhaling a solution can help reduce nausea in people with cancer. It will compare the effects of the study solution to a placebo (an inactive substance) in 112 participants. The goal is to find a simple, non-drug method to help manage this common and…

This study is testing a program called FoodiiS-Kids to see if it's helpful for parents of children who have finished cancer treatment. The program provides food deliveries and cooking lessons. Researchers want to know if parents find it useful and if it helps them cook healthier …

This study is testing a virtual lifestyle program to see if it can help women with stable, advanced breast cancer improve their diet, exercise, and stress management. It will compare three different levels of support to find the best way to help participants stick with the progra…

This study is testing a new support program called IGNITE-TX. It aims to help families communicate better about inherited cancer risks and make informed decisions about getting genetic testing. The program will be offered to people with certain genetic mutations (like BRCA) and t…

This study aims to understand if a doctor using a computer during a visit affects how patients view the doctor's compassion and communication. Researchers will show 88 cancer patients videos of two different doctor visit styles and ask for their opinions. The goal is to gather kn…

This study aims to understand the real-world challenges and supports for getting timely cancer treatment in Texas. Researchers will conduct interviews and group discussions with 120 patients who have breast, colorectal, lung, or prostate cancer. The goal is to identify the main b…

This study aims to understand why some people experience chronic loose stools after colon cancer surgery. Researchers will use a new sampling device to examine bile acids and bacteria in the digestive system of 20 participants who have had this surgery. The goal is to learn how t…

This study aims to understand how migration history and social factors affect prostate cancer care and quality of life for Black immigrant men. Researchers will interview 40 men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. The goal is to…

This study aims to understand the quality of life for women who were treated for breast cancer while they were pregnant. Researchers will survey 50 survivors to learn about their current well-being, anxiety, and support systems. The goal is to gather information to better support…

This study aims to understand how tiny traces of cancer DNA in the blood change during and after treatment for early-stage breast cancer. Researchers will follow 300 patients, taking blood samples at different points to see if these DNA signals can help predict if the cancer migh…

This study is creating and testing a new educational tool to help prostate cancer patients understand and complete recommended genetic testing. Researchers will work with 108 patients at Lyndon B. Johnson Hospital to identify barriers to testing and see if their decision support …

This study aims to understand and improve how cancer care teams communicate with patients. Researchers will observe clinic visits and collect feedback from 200 patients with advanced cancer to compare how different types of care teams discuss patient needs and concerns. The goal …

This early-stage study aims to understand how a standard cancer drug (cabozantinib) changes the immune environment inside bones where kidney cancer has spread. Researchers will take small tissue samples (biopsies) from 16 patients' bone tumors before and after treatment to see ho…

This study aims to collect medical information and samples from cancer patients who have, or are at risk for, serious fungal infections like mucormycosis. Researchers will analyze blood, tissue, and fluid samples to better understand how these infections develop and progress. The…

This study aims to understand if recording a doctor's visit helps cancer patients remember important information and share it with family members who couldn't attend. Researchers will ask 200 patients with advanced cancer to record their clinic visit and then complete a survey ab…

This study aims to create and test educational materials about medullary thyroid cancer specifically designed for the Latino/Latina community. Researchers will work with 40 participants, including patients and caregivers, to adapt existing information to be more culturally releva…