M.d. Anderson Cancer Center

This phase 2 trial tests the drug mosunetuzumab in 30 people with chronic lymphocytic leukemia (CLL) who still have detectable cancer cells after at least six months of standard therapy. The goal is to see if the drug can clear those remaining cells and improve outcomes. Particip…

This phase 1 trial tests a new cell therapy called KITE-753 for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to standard treatments. KITE-753 is made from a patient's own immune cells, which are modified to recognize and attack leuke…

This phase 2 trial is testing whether a combination of three drugs—zanubrutinib, sonrotoclax, and obinutuzumab—can safely control chronic lymphocytic leukemia (CLL) in people who have not yet received treatment. About 40 participants will receive all three drugs orally. The main …

This early-phase study tests two drugs, blinatumomab and revumenib, given together to adults with a rare and aggressive form of acute lymphoblastic leukemia (ALL) that has a specific genetic change called KMT2A rearrangement. The main goal is to find a safe dose and understand si…

This pilot study tests whether the drug infliximab can safely reverse insulin dependence in people who developed diabetes after taking checkpoint inhibitor cancer therapy. About 14 participants will receive the drug and be monitored for side effects and changes in their need for …

This early-stage trial is testing a new drug called REC-617 in 15 people with a rare type of sarcoma (leiomyosarcoma) that has spread or cannot be removed and has not responded to prior treatments. The drug targets a protein (CDK7) that helps cancer cells grow. The main goal is t…

This pilot study tests the drug ivonescimab in people with advanced or metastatic cutaneous angiosarcoma, a rare and aggressive skin cancer. Participants must have already received chemotherapy with paclitaxel or docetaxel. The study aims to see if ivonescimab is safe and can shr…

This study tests adding ropeginterferon alfa-2b to the standard drug azacitidine for people newly diagnosed with a type of blood cancer (MDS or AML) that has a specific genetic change called a TP53 mutation. The goal is to find the safest dose of the combination and see if it can…

This study tests a virus called G207 combined with a small dose of radiation in children whose high-grade glioma has come back or is growing. The goal is to see if the treatment is safe and helps control the tumor. About 38 children will take part.

This study tests whether combining dasatinib with ropeginterferon can better control chronic myeloid leukemia in its early phase. About 40 adults newly diagnosed with CML will receive the drug pair to see if it improves disease control and reduces side effects. The goal is to man…

This early-phase trial tests whether specially engineered immune cells (NK cells) can safely treat high-risk precancerous spots in the mouth. The cells are injected directly into the lesions and are designed to target a protein called TROP2, while also resisting signals that norm…

This early-phase trial tests whether matching drug combinations to a patient's tumor characteristics can better control metastatic colorectal cancer. Researchers will use blood draws, biopsies, and imaging to track how tumors resist treatment. The study enrolls 100 adults with me…

This study tests a new treatment called CD70.CAR NK cells for people with diffuse large B-cell lymphoma or Hodgkin lymphoma that did not respond to or came back quickly after initial therapy. The treatment uses specially designed immune cells from a donor to find and attack cance…

This study tests a combination of seven drugs (including asciminib and venetoclax) in 30 adults with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute myeloid leukemia. The first phase checks safety, and the second phase sees if the combo helps control t…

This early-phase study tests two drugs together—navlimetostat and pumitamig—in people with advanced non-small cell lung cancer that has a specific genetic change (MTAP-deficient). The main goal is to find a safe dose and see if the combination helps shrink tumors. About 17 adults…

This study tests whether adding nivolumab to standard chemotherapy (AVD) can better control early-stage Hodgkin lymphoma in patients aged 2 to 21. The treatment is given to 15 participants to see if it is safe and effective. The goal is to improve outcomes while reducing long-ter…

This early-phase study tests a new drug called PLM-102 in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to find the highest safe dose and to monitor side effects. Participants must have relapsed or refractor…

This early-phase trial tests two oral drugs, olutasidenib and ziftomenib, together in 20 adults with a specific form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The first part finds a safe dose; the second checks if that dose helps control the…

This early-stage trial tests a new approach for people with recurrent glioblastoma, an aggressive brain cancer that has come back after standard treatment. Researchers will give patients specially engineered natural killer (NK) cells, either directly into the brain or through an …

This early-phase trial is testing a new treatment called LNK001 for people with advanced or metastatic clear cell renal cell carcinoma (a type of kidney cancer) that has not responded to standard treatments. LNK001 is a type of immunotherapy where a patient's own immune cells are…

This early-phase trial tests a virus called DNX-2401, designed to infect and destroy melanoma cells in the brain and body. About 50 adults with stage IV melanoma will receive injections to find the safest dose and number of treatments. The main goal is to check for side effects, …

This early-phase trial tests a new treatment for stomach cancer that has spread to the lining of the abdomen. Ten adults will receive specially engineered immune cells (NK cells) infused directly into the abdomen, along with standard chemotherapy drugs. The main goals are to find…

This study tests whether a drug called blinatumomab, given as a simple injection under the skin, can control small amounts of leftover leukemia cells (called measurable residual disease, or MRD) in adults with B-cell acute lymphoblastic leukemia. The goal is to prevent the cancer…

This Phase 2 trial tests a combination of two drugs—blinatumomab (given as a shot under the skin) and olverembatinib (a pill)—in 60 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). The goal is to see if this combo can control the disease safely. Pa…

This early-phase trial tests a new combination treatment for people with advanced breast cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (TRICK-NK) plus a targeted drug called T-Dxd. The study aims to find the safest dose …

This Phase 2 trial tests the drug imetelstat in 30 adults with myelodysplastic/myeloproliferative neoplasms (MDS/MPN), a rare blood cancer. The goal is to see if imetelstat can help control the disease and to check for side effects. Participants receive the drug by IV, and the st…

This study tests whether a combination of two drugs, zanzalintinib and cemiplimab, can help people with a rare and fast-growing thyroid cancer called anaplastic thyroid cancer live longer. The goal is to extend average survival by about 4 months. The trial will include 12 adults …

This phase 2 study tests the drug zanzalintinib in 16 adults with recurrent or metastatic olfactory neuroblastoma, a rare cancer of the nasal cavity. The goal is to see if the drug can help control the disease and to check its safety. Participants must not have had prior treatmen…

This phase 2 trial tests three immune-boosting drugs (cemiplimab, fianlimab, and ipilimumab) given before surgery in 20 people with advanced but removable melanoma. The goal is to see if the combination is safe and can shrink tumors, potentially improving outcomes. Participants m…

This study tests a drug called sacituzumab tirumotecan in 20 people with advanced anal or rectal cancer that has spread or cannot be removed and has not responded to other treatments. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive t…

This phase 2 trial is testing two oral drugs, BGB-16673 and sonrotoclax, in 40 people with untreated chronic lymphocytic leukemia (CLL). The goal is to see if this combination can safely control the disease for a limited time, potentially reducing the need for ongoing therapy. Pa…

This Phase 2 trial tests a new treatment for aggressive T-cell blood cancers. Patients receive specially engineered natural killer (NK) cells from donated cord blood, along with chemotherapy, to try to keep the cancer in remission. The study will enroll 70 adults aged 18-80 whose…

This study tests an oral chemotherapy drug, cladribine, combined with two other drugs (low-dose cytarabine and venetoclax) in people with acute myeloid leukemia (AML). The first part finds the safest dose; the second part checks if that dose helps control the disease. About 58 ad…

This study tests a drug called sacituzumab tirumotecan in 20 people with a rare and aggressive kidney cancer (SMARCB1-deficient renal medullary carcinoma) that has worsened after at least one prior treatment. The goal is to see if the drug can shrink or control the cancer. Resear…

This early-phase trial tests a combination of four drugs—pazopanib, trabectedin, ipilimumab, and nivolumab—in children and young adults up to age 30 whose soft tissue sarcomas have come back. The goal is to see if adding pazopanib to the existing three-drug regimen is safe and he…

This early-phase trial is testing a combination of two drugs—izalontamab brengitecan (given by IV) and adagrasib (a pill)—in 18 adults with advanced KRAS G12C-mutant non-small cell lung cancer that has stopped responding to other treatments. The main goal is to check safety and s…

This early-phase trial tests whether immune cells (CD8+ T cells) given through a spinal tap are safe for people with melanoma that has spread to the lining of the brain. Only 8 participants will receive the treatment. The main goal is to check for side effects, not to cure the di…

This study tests whether using the Provox ActiValve voice prosthesis as a first choice can reduce the number of times the device needs to be replaced each year in people who have had their voice box removed (laryngectomy) and have a tracheoesophageal puncture (TEP). The trial wil…

This early-phase trial tests whether combining three drugs—ruxolitinib, cladribine, and venetoclax—can control T-cell prolymphocytic leukemia (T-PLL) that has returned or not responded to prior treatment. The study will enroll 36 adults and primarily monitor safety and side effec…

This study tests whether drawing blood directly from veins inside the brain can safely diagnose high-grade glioma, a type of brain cancer. Researchers will compare this liquid biopsy to traditional surgical biopsy. Only 20 adults with suspected or confirmed brain cancer will part…

This study tests a special microscope that takes very clear, detailed pictures of cervical tissue right where the patient is being seen. The goal is to see if it can give doctors the same quality images as a standard lab test, but much faster. About 400 women in Mozambique and Br…

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This trial tests a program that combines palliative care with remote monitoring and telehealth to better support people with advanced cancer. Participants complete questionnaires and physical exams, and their care is tailored to their needs. The study includes 300 adults with met…

This pilot study tests a program called COPE (Creating Opportunities for Personal Empowerment) in 40 women with stage I-III breast cancer who are starting their first treatment. Participants will either receive the 7-week COPE sessions plus standard care, or standard care alone. …

This study looks at whether inhaling isopropyl alcohol (rubbing alcohol) can help reduce nausea in cancer patients. About 112 adults with cancer who rate their nausea as at least 4 out of 10 will be asked to inhale the alcohol and report any changes. The goal is to find a quick, …

This study tests if a program that delivers healthy food and teaches cooking skills is helpful for parents of children who have finished cancer treatment. The study will include 21 parents of children aged 5-12 who completed cancer therapy within the last five years. Researchers …

This study tests a virtual group lifestyle program for women with metastatic breast cancer. The goal is to see if more support helps them stick with healthy habits like diet and exercise. One hundred women will take part, and researchers will track safety and how well they follow…

This study will give 50 women a Fitbit Inspire 3 to wear before and after DIEP flap breast reconstruction surgery. Researchers will track steps, heart rate, and sleep, and compare that data with short questionnaires about recovery. The goal is to learn more about how patients rec…

This phase 2 trial is testing whether blood tests and imaging scans can tell if chemotherapy is working in people with early-stage triple-negative breast cancer before they go to surgery. The study will enroll 200 participants who will receive a combination of chemotherapy drugs …

This study follows 250 gynecologic cancer patients and their informal caregivers over 6 months. Researchers will use surveys to track caregiver distress and unmet needs. The goal is to understand what caregivers go through and find ways to better support them.

This study interviews 20 pancreatic cancer patients to learn why certain groups—like racial minorities, low-income individuals, or rural residents—are less likely to join clinical trials. Researchers hope to find ways to make trials more accessible and fair for everyone. The stud…

This study tests a program to help people with inherited cancer gene mutations (like BRCA or Lynch syndrome) stick to recommended cancer screening schedules. Researchers will interview 80 female participants and provide standard care to see if this approach improves adherence and…

This study will test whether intermittent fasting (eating only during an 8-hour window each day) is safe and doable for 20 people at high risk for pancreatic cancer. Researchers will also check if this eating pattern changes certain markers in the body linked to cancer risk. The …

This study looks at how cancer care is provided in oncology and supportive care clinics. Researchers will collect feedback from 200 adults with advanced solid tumors to better understand and improve care delivery. The goal is to help doctors learn from patient experiences, not to…

This early-stage study tests whether a magnetic tracer and a fluorescent dye can safely help doctors find lymph nodes where stomach cancer may have spread. About 20 adults with early stomach cancer will receive the injection before surgery. The goal is to see if this method is sa…

This study tests whether a special catheter called TriNav can deliver more radiation beads (Y90 microspheres) to liver tumors while reducing exposure to healthy liver tissue. Twenty adults with unresectable liver tumors will receive the standard radioembolization procedure using …

This study will interview 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will talk with patients by phone or video to understand their experiences across different cancer types and insurance plans. The goal is to i…

This study looks at how cancer patients view their doctor's compassion, communication, and professionalism when the doctor uses an electronic health record (EHR) during the visit. About 88 adults with cancer will watch videos or fill out questionnaires. The goal is to understand …

This study looks at what helps or hinders prostate cancer patients from completing genetic testing. Researchers will develop and test a decision support tool to educate patients and help them decide about testing. The goal is to increase testing rates, which can guide treatment a…

This study looks at whether audio recording a clinic visit helps advanced cancer patients remember what their doctor said and share it with family. About 200 patients at MD Anderson Cancer Center will be asked to record part of their visit and later report if it was useful. The g…

This study tests a program to help people with certain genetic mutations share their results with at-risk relatives and make informed decisions about genetic testing and care. About 2100 adults in the U.S. who speak English or Spanish will take part. The program provides free gen…

This study looks at why some people have ongoing loose stools after surgery for colon cancer. Researchers will use a new device to check for bile acid problems and bacterial overgrowth in the small intestine. The goal is to better understand these symptoms and how they affect qua…

This study aims to understand how migration history and social factors affect the quality of life of Black immigrant men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. Researchers will interview 40 men to learn about their experiences and …

This early study will look at how two drugs, cabozantinib and nivolumab, change the bone immune environment in 16 people with kidney cancer that has spread to bone. The main goal is to check safety and see how the bone environment responds. It is a proof-of-concept study, meaning…

This study will collect medical information and samples from 300 cancer patients who have or are at risk for a serious fungal infection called mucormycosis. Researchers hope to learn more about how the infection develops and how to better diagnose and manage it. Participants will…