Supercharged immune cells take on deadly brain tumors

NCT ID NCT07579208

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new approach for people with recurrent glioblastoma, an aggressive brain cancer that has come back after standard treatment. Researchers will give patients specially engineered natural killer (NK) cells, either directly into the brain or through an IV, to see which method is safer. The study involves 36 adults and focuses on side effects and the best way to deliver the cells.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

engineered natural killer (NK) cells

What this could lead to

If it works, this could point toward a new treatment option for recurrent glioblastoma, a brain cancer with few options.

What could go wrong

This is a very early Phase 1 trial with only 36 people. It is designed mainly to check safety, not yet to prove the treatment works. There may be side effects from the cells or the delivery method.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

astrocytoma, IDH-mutant, grade 4 glioblastoma gliosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact