M.d. Anderson Cancer Center

This study is testing a combination of three drugs to try to cure patients with a specific, aggressive type of leukemia called acute promyelocytic leukemia (APL). The goal is to see if using these drugs together can eliminate the cancer for good, allowing patients to stop treatme…

This study aims to determine whether delivering focused radiation before surgery works better than after surgery for patients with cancer that has spread to the brain. It will compare two approaches in 180 participants to see which timing is more effective at preventing cancer fr…

This early-stage trial is testing new combinations of targeted drugs for people with advanced colorectal cancer that has spread and cannot be surgically removed. The study aims to find safe doses of a new drug called ulixertinib when given with other cancer medications to patient…

This study is testing a combination of three oral drugs to treat acute myeloid leukemia (AML) that has come back or hasn't responded to previous treatments. The goal is to see if this combination is safe and can help control the cancer. The trial will enroll about 84 adults with …

This study is testing whether a combination of two drugs, acalabrutinib and obinutuzumab, can control chronic lymphocytic leukemia (CLL) for a period of time without needing continuous treatment. The main goal is to see if patients can stop all therapy and remain in remission for…

This early-stage study is testing a new chemotherapy combination called CPX-351 in adults with high-risk myelodysplastic syndrome or chronic myelomonocytic leukemia that has come back or hasn't responded to standard treatments. The main goals are to find the safest dose and under…

This early-stage study is testing a new nanoparticle treatment called NBTXR3 for people with esophageal cancer. The nanoparticles are injected directly into the tumor and are designed to make radiation therapy more effective at killing cancer cells when combined with standard che…

This study is testing a new combination treatment for people with severe autoimmune diseases like lupus and scleroderma who haven't responded well to standard therapies. It involves giving specially modified immune cells (AD-PluReceptor-NK cells) along with a drug called tafasita…

This early-stage study is testing whether stem cells from donor bone marrow can help improve heart function in cancer survivors who developed heart damage from certain chemotherapy drugs. Researchers will compare two different methods of delivering the stem cells (through an IV o…

This study is testing whether a combination of two drugs, pirtobrutinib and rituximab, can provide long-term remission for people newly diagnosed with a slower-growing form of mantle cell lymphoma (MCL) without using traditional chemotherapy. It will enroll 50 adults with low or …

This study is testing whether the drug asciminib can effectively control chronic myeloid leukemia (CML) in adults recently diagnosed with the disease. Researchers will enroll 50 participants to measure how well the drug reduces cancer markers and monitor side effects over time. T…

This study is testing whether adding an immunotherapy drug (obinutuzumab) earlier to a two-drug combination (acalabrutinib + venetoclax) works better for people with chronic lymphocytic leukemia (CLL) that has returned or hasn't responded to previous treatments. The goal is to be…

This early-stage study is testing a new combination of three drugs—cyclophosphamide, axatilimab, and retifanlimab—for people with metastatic triple negative breast cancer that has spread and is no longer responding to standard treatments. The main goal is to find the safest and m…

This study is testing an experimental drug called ivonescimab in people with metastatic colorectal cancer that has stopped responding to standard treatments. Ivonescimab is designed as a single drug that targets two different pathways cancer uses to grow and evade the immune syst…

This study is testing whether the drug sacituzumab govitecan can help control advanced salivary gland cancers that have returned or spread. The trial will enroll about 30 adults whose cancer cannot be cured with surgery or radiation. Researchers will measure how well the drug shr…

This study is testing whether freezing just the cancerous part of the prostate gland can effectively control prostate cancer. Researchers will treat 30 men with intermediate-risk prostate cancer using this targeted freezing approach, then monitor them for cancer recurrence and qu…

This early-stage study is testing a more precise form of proton beam radiation therapy for children with a type of brain tumor called ependymoma. The main goal is to see if this refined technique is safe and causes fewer side effects by better targeting the tumor and sparing heal…

This study is testing whether combining three chemotherapy drugs can help control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The treatment is for older adults or those who cannot tolerate standard intensive chemotherapy, including some with relapsed…

This study is testing whether giving radiation therapy and chemotherapy at the same time can help control early-stage nasal NK cell lymphoma, a rare type of cancer. Researchers want to see if this combined approach is safe and effective at keeping the cancer from progressing. The…

This study is testing whether a drug called dexrazoxane can protect the heart from damage caused by powerful chemotherapy used to treat aggressive blood cancers like acute myeloid leukemia. It will enroll 100 patients with these cancers who are receiving a specific combination of…

This study is testing several combinations of targeted drugs for adults with relapsed or hard-to-treat blood cancers that have specific genetic mutations. The main goals are to see if these combinations are safe and if they can help put the cancer into remission. Participants wil…

This study is testing whether a drug called olverembatinib can effectively control newly diagnosed chronic myeloid leukemia (CML) when used alone. It will involve 50 adults with early-stage CML to measure how well the drug reduces cancer markers and manages the disease over time.…

This study is testing if breast cancer patients who respond exceptionally well to initial drug therapy can safely skip surgery or radiation. It is for women with early-stage breast cancer where a special biopsy shows no cancer remains after the drug treatment. The goal is to see …

This study is testing a new oral drug, seclidemstat, combined with an existing drug, azacitidine, for adults with certain advanced blood cancers (MDS and CMML) that have not responded well to prior treatment. The main goals are to find the safest and most effective dose of the ne…

This study is testing a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—to see if they can safely slow or stop the growth of kidney cancer that has spread to the brain. It is for adults with this specific type of cancer who have not yet received treatment for t…

This study is for people with advanced pancreas cancer that has spread to only a few other spots in the body. It tests if adding targeted local treatments—like surgery or radiation—to all cancer spots, on top of standard drug therapy, helps control the cancer for a longer time co…

This study is testing a combination of three drugs—quizartinib, decitabine, and venetoclax—to treat acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). It is for older adults who are not candidates for standard intensive chemotherapy or for those whose disea…

This early-phase study is testing whether a combination of chemotherapy, radiation therapy, and an immunotherapy drug called dostarlimab can help control stage IIIC endometrial cancer that has spread to lymph nodes. Researchers will primarily check if this three-part treatment is…

This study is testing a combination of four chemotherapy drugs (cladribine, idarubicin, cytarabine, and venetoclax) to see how well they work against aggressive forms of blood cancer, including acute myeloid leukemia (AML), high-risk myelodysplastic syndrome (MDS), and chronic my…

This study is testing whether adding a third immunotherapy drug to a standard two-drug combination works better for advanced kidney cancer. The trial will compare a three-drug combination against the standard two-drug treatment in patients who haven't received any prior cancer th…

This study aims to find a safe and effective dose of a three-drug combination (eribulin, irinotecan, and temozolomide) for children and young adults with solid tumors that have come back or not responded to other treatments. The main goal is to see how much of the drug eribulin c…

This study is testing a new cell therapy for adults with certain blood cancers that have returned or not responded to standard treatments. Doctors will give patients specially engineered immune cells (called CAR-NK cells) made from donated cord blood, along with a short course of…

This study is testing a new cell therapy for multiple myeloma that has come back or stopped responding to standard treatments. Doctors are giving patients immune cells (NK cells) from donated umbilical cord blood that have been genetically modified to better find and attack the c…

This study is testing a new combination of three drugs to see if they can help control advanced bile duct cancer (cholangiocarcinoma) that has a specific genetic change called an FGFR2 fusion. The trial will enroll about 25 adults whose cancer has progressed after standard treatm…

This early-stage study is testing a new combination treatment for gynecologic cancers that have returned after previous therapy. Researchers are combining an oral drug called talazoparib with standard radiation therapy to see if it works better together. The main goal is to find …

This is an early-stage study to find the safest and most effective dose of a new personalized cell therapy called JV-213. It is for adults with B-cell lymphoma that has come back or not responded to at least two prior treatments. The therapy involves collecting a patient's own im…

This study is testing if adding the antibiotic metronidazole to standard pre-surgery treatment for rectal cancer can reduce certain harmful bacteria in the gut. Researchers want to see if this change improves how well the cancer responds to treatment. The trial will enroll 60 adu…

This study is testing a new approach for people with stage II-III rectal cancer. After standard chemotherapy and radiation, patients whose cancer appears to be gone will be closely monitored instead of immediately having surgery. The goal is to see if this 'watch and wait' strate…

This study is testing a combination of five drugs to treat adults newly diagnosed with specific, aggressive forms of blood cancer. The goal is to see if this combination is safe and effective at putting the cancer into remission. The treatment involves chemotherapy and a targeted…

This early-stage trial is testing three different drug combinations to find safe doses and see if they can help control advanced solid tumors that have spread. The study will enroll about 111 adults with specific genetic features in their cancer. Researchers aim to see if combini…

This study is testing whether combining three existing drugs—pembrolizumab, bevacizumab, and low-dose cyclophosphamide—can help control high-grade ovarian cancer that is still present in small amounts after a patient's first round of treatment. The goal is to see if this combinat…

This study is testing whether a drug called tasquinimod can help control myelofibrosis, a serious bone marrow cancer. It will be given either by itself or alongside an existing drug (ruxolitinib) to 33 adults whose current treatments aren't working well enough. The main goals are…

This study is testing whether a personalized approach using the drug apalutamide can reduce fatigue and other side effects for men receiving radiation treatment after prostate cancer surgery. Researchers will compare apalutamide-based treatments against standard hormone therapy i…

This study is testing whether combining the drugs tivozanib and nivolumab can help control advanced non-clear cell kidney cancer. It will enroll about 48 adults with this specific type of cancer who have had up to one prior treatment. The main goals are to see if the combination …

This study is testing a combination of two immunotherapy drugs for people with a type of blood cancer called large B-cell lymphoma that has returned or didn't respond to first treatment. The goal is to see if using a personalized cell therapy (axi-cel) together with a targeted an…

This study is testing whether stem cells from umbilical cord blood can help control severe COVID-19 pneumonia. The trial will involve 70 hospitalized adults with moderate to critical pneumonia, comparing stem cell infusions against standard care. Researchers want to see if these …

This early-stage study is testing a new cell therapy for people with advanced ovarian or pancreatic cancer that has stopped responding to standard treatments. Doctors are giving patients specially modified immune cells, called CAR-NK cells, directly into the abdomen to try to att…

This study is testing if using a Fitbit to track and encourage walking after lung cancer surgery helps patients recover better. Researchers want to see if patients who walk more have fewer complications and a better quality of life after their operation. The study will compare th…

This study is testing a radiation treatment called Y-90 radioembolization for patients whose colorectal cancer has spread to the liver. The goal is to see if this treatment can safely shrink tumors on one side of the liver while encouraging the healthy side to grow larger. This c…

This study is testing a drug called asciminib for adults with chronic myeloid leukemia (CML) when their first standard treatment has stopped working or caused intolerable side effects. The main goal is to see how well asciminib controls the leukemia by measuring a specific marker…

This study is for people with kidney cancer that has spread to a few other places in the body. It aims to see if adding one year of a drug called pembrolizumab (an immunotherapy) after radiation treatment helps keep the cancer under control for longer, compared to just having rad…

This study is testing whether a drug called zanidatamab can eliminate early-stage HER2-positive breast cancer before surgery. It will involve about 20 patients who haven't had any prior cancer treatment. Researchers will check if the cancer completely disappears after taking the …

This study aims to understand how targeted cancer treatments affect tiny amounts of remaining cancer DNA in the blood of colorectal cancer patients who have completed initial treatment. Researchers will monitor 40 patients receiving standard targeted therapies based on their spec…

This study is testing whether a combination of two drugs, fruquintinib and tislelizumab, can help control colorectal cancer in patients who have finished their initial chemotherapy but still have tiny amounts of cancer left in their body, detected by a special blood test. The goa…

This study is testing whether adding two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can better control advanced oral cavity cancer. It is for adults newly diagnosed with a specific type of tumor (PD-L1 positive) that is…

This early-stage study is testing a new treatment for people with advanced synovial sarcoma or myxoid/round cell liposarcoma. Researchers are giving patients donated immune cells (NK cells) that have been specially engineered to find and attack cancer. The main goals are to find …

This study is testing an oral drug called revumenib to see if it can help control leukemia that has returned or not responded to other treatments and is driven by specific genetic changes involving HOX genes. It will enroll about 40 patients aged 12 and older. The main goals are …

This study is testing whether very low doses of radiation can effectively control skin lesions caused by mycosis fungoides, a type of skin lymphoma. It aims to see if this approach can manage the disease while potentially causing fewer side effects than standard, higher-dose radi…

This is a first-in-human study testing a new type of cell therapy for glioblastoma that has returned after treatment. Doctors are giving patients genetically modified immune cells, called NK cells, directly into the brain to see if they can attack the cancer. The main goals are t…

This is an early-stage study testing a new type of cell therapy for people with advanced solid tumors that have stopped responding to standard treatments. Doctors are using specially engineered immune cells from donated cord blood, designed to target a protein called TROP2 found …

This study is testing a combination of six chemotherapy drugs for people whose acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma has come back or hasn't responded to previous treatments. The goal is to see if this intensive combination is safe and can effectively contr…

This study aims to see if a person's unique brain activity can predict which type of non-invasive brain stimulation helps them smoke less. Researchers will use brain scans and a technique called rTMS on 100 adult smokers. The goal is to match the right brain stimulation treatment…

This study is testing a combination of two drugs, atezolizumab and cabozantinib, for adults with glioblastoma that has returned after initial treatment. The goal is to see if this combination is safe and can help control the cancer by boosting the immune system and blocking tumor…

This study is testing a remote monitoring system for men with prostate cancer who are on 'active surveillance'—a plan to watch the cancer closely instead of treating it right away. It aims to see if tracking symptoms and disease progression electronically can help doctors decide …

This study is testing whether combining two drugs, blinatumomab and asciminib, can help control a fast-growing blood cancer called Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). It will involve about 40 adults and teenagers, including those newly diagnosed and thos…

This study is testing whether adding a newer drug called venetoclax to a standard, strong chemotherapy regimen works better for adults with acute myeloid leukemia (AML). The goal is to see if this combination is safe, find the best dose, and measure how well it controls the cance…

This early-stage trial is testing a new type of personalized cell therapy for people with advanced soft tissue or bone sarcoma that has spread or come back. Researchers will take a patient's own immune cells, modify them in a lab to better target the cancer, and then infuse them …

This study is testing whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—can help control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back after prior treatment. It will enroll about 40 adults who have been tr…

This study tests whether the drug emapalumab can safely treat severe, prolonged low blood counts that sometimes occur after CAR-T cell therapy for lymphoma. Researchers will enroll 32 adults who developed this complication between 30-90 days after their CAR-T treatment. The goal …

This study is testing a new combination of three oral drugs for people with acute myeloid leukemia (AML). The first part aims to find the safest and most effective dose. The second part will see if that dose can help control the cancer in patients who are newly diagnosed but not …

This study is testing if stopping a CMV prevention drug (letermovir) based on a patient's own immune response works better than taking the drug every day for 200 days after a stem cell transplant. It aims to find the safest and most effective way to prevent serious CMV infections…

This early-stage trial is testing a new treatment that combines modified immune cells with chemotherapy for people with advanced kidney cancer, mesothelioma, or bone cancer. Researchers will give patients donated immune cells that have been engineered in a lab to better target an…

This early-stage trial is testing the safety of combining a wearable device that uses electric fields to disrupt cancer cells with different drug combinations. It is for adults with advanced cancers in the abdomen or chest that have spread and who have run out of standard treatme…

This study is testing whether a combination of three drugs—adagrasib, cetuximab, and cemiplimab—can help control metastatic colorectal cancer that has a specific genetic change called a KRAS G12C mutation. The trial aims to see how well the treatment works and how safe it is for …

This study provides compassionate access to an experimental stem cell infusion for patients whose immune systems are not recovering properly after a stem cell transplant. The goal is to boost the patient's blood cell counts by giving them a concentrated dose of healthy donor stem…

This is an early-stage study to test the safety and find the right dose of a new personalized cell therapy called JV-394. It is for adults with specific types of T or NK cell lymphomas that have come back or not responded to at least one prior treatment. The therapy involves coll…

This early-stage study is testing the safety and best dose of a two-drug combination (alpelisib and pembrolizumab) for patients with advanced breast cancer or melanoma that has spread. It aims to see if this combo can help control the disease, including in cases where cancer has …

This study is testing a new drug, NADUNOLIMAB, in combination with standard treatments for two types of blood cancer: Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML). The main goals are to find a safe dose and see if this new combination can help control the disea…

This study is testing whether a more intensive combination of radiation therapy and chemotherapy can better control certain aggressive brain tumors. It will involve about 40 adults with specific types of fast-growing brain cancer. Researchers aim to see if this stronger treatment…

This study is testing a new combination of three drugs—ziftomenib, venetoclax, and gemtuzumab—for children and young adults whose acute myeloid leukemia has come back or hasn't responded to other treatments. The main goal is to find the safest and most effective dose of this comb…

This study is testing whether a medication called canakinumab, given as a monthly injection, can help control certain low-risk blood and bone marrow disorders. It aims to see if the treatment improves blood counts, reduces the need for blood transfusions, and is safe for patients…

This study is for people with stage III non-small cell lung cancer that has started to grow again (progressed) after their initial chemo-radiation and immunotherapy. It tests whether using targeted treatments like surgery or radiation to attack specific progressing tumors, follow…

This study is testing a targeted radiation drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has spread to the bone marrow and caused low blood cell counts. The main goal is to see if the treatment is safe and effective for this specific group of patients who o…

This is an early-stage study to find a safe dose of a new oral drug, HC-7366, for adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatments. Researchers will enroll about 18 participants to check for side effects and see if the drug shows …

This early-stage trial is testing a new treatment for aggressive brain cancers that have returned. Doctors are using stem cells to carry a specially engineered cold virus directly to the tumor. The goal is to see if the virus can safely infect and kill the cancer cells while spar…

This study is testing whether a new drug called golidocitinib can help control a rare and aggressive type of blood cancer called peripheral T cell lymphoma (PTCL). It will involve about 30 adults who have just been diagnosed and have not yet received treatment. Researchers want t…

This study aims to find out if short or long IV catheters work better for cancer patients who need emergency care and have difficult veins. Researchers will compare how often each type fails, how long they last, and whether they cause infections or blood clots. The goal is to imp…

This early-stage study is testing a new type of cell therapy for people with advanced clear cell kidney cancer that has stopped responding to standard treatments. Doctors will give participants specially engineered immune cells designed to find and attack their cancer. The main g…

This study is testing a new cell therapy for patients whose blood cancers have returned or not responded to standard treatments. Researchers are giving patients specially engineered immune cells, called NK cells, which come from donated cord blood. The goal is to see if these mod…

This study is testing if adding a drug called venetoclax to a standard chemotherapy and stem cell transplant regimen works better for adults with high-risk forms of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to see if this combination helps contro…

This study is testing a new three-part treatment for patients with advanced cancer that has spread to the lungs or liver. The goal is to see if a drug called NBTXR3, which is injected directly into a tumor, makes cancer cells more sensitive to radiation. Patients also receive an …

This early-stage study is testing the safety and best dose of a two-drug combination (Hyper-CVAD and venetoclax) for children and young adults (ages 2-21) whose leukemia has returned or hasn't responded to other treatments. The main goal is to see how much of the drug combination…

This early safety study is testing whether transplanting healthy gut bacteria from donor stool can help control pancreatic cancer. It involves 10 patients with pancreatic cancer who are scheduled for surgery. Patients receive the transplant via colonoscopy and then take weekly ca…

This study is testing a precise, high-dose radiation treatment for liver tumors that cannot be surgically removed. It is designed for patients whose tumors are too large or located too close to major blood vessels or sensitive organs for standard heat-based treatments. The goal i…

This early-stage study is testing a new drug called belumosudil for people with multiple myeloma, a blood cancer, that has come back or stopped responding to standard treatments. The first part aims to find a safe dose. The second part will see if that dose, given alone or with a…

This study is testing whether a combination of a gentle, full-body radiation treatment and a targeted drug can help control mycosis fungoides, a type of skin lymphoma, in patients whose disease has come back or hasn't responded to other treatments. The trial will enroll about 30 …

This study is testing whether two oral medications, venetoclax and revumenib, can work together to eliminate minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) who are in remission. MRD refers to a small number of cancer cells that remain after treatment…

This study is testing whether giving radiation to only one side of the neck is safe and reduces side effects for people with throat cancer located on one side. Currently, most patients receive radiation to both sides of the neck, which can cause more side effects. Researchers wan…

This study is testing a new cell therapy for adults whose blood cancers have returned or not responded to other treatments. Doctors will give patients specially engineered immune cells from donated cord blood, aiming to find a safe and effective dose. The goal is to see if this a…

This study is testing whether a pill called larotrectinib can help control advanced solid tumors that have a specific genetic feature (NTRK gene amplification). The trial is for patients aged 16 and older whose cancer has spread and who have already tried standard treatments. Res…

This study is testing whether adding a new drug called epcoritamab to a standard, gentler chemotherapy combination can help control a fast-growing type of blood cancer called diffuse large B-cell lymphoma (DLBCL). It is specifically for older adults or those with heart problems w…

This study is testing a new personalized cell therapy called KSQ-004EX for people with advanced solid tumors that have stopped responding to standard treatments. The therapy involves collecting a patient's own immune cells from their tumor, genetically modifying them to be more p…

This study is testing two new drug combinations for people with advanced, BRCA-positive breast cancer that has spread and has stopped responding to a standard type of targeted therapy (PARP inhibitors). The trial will see if adding a second drug to the standard one can shrink tum…

This study is testing whether surgery to remove the stomach, combined with chemotherapy delivered directly into the abdomen, can help people with advanced stomach cancer that has spread to the abdominal lining. The trial aims to see if this combined approach improves survival and…

This study is testing whether the drug brentuximab vedotin can help control advanced malignant mesothelioma that has a specific marker called CD30 and cannot be removed by surgery. About 55 patients who have already tried other treatments will receive the drug through an IV every…

This study is testing whether adding radiation therapy to standard immunotherapy helps prevent melanoma from coming back in the lymph nodes. It's for patients whose melanoma has spread to a nearby lymph node but hasn't traveled further. Participants are randomly assigned to recei…

This study aims to understand if crushing a medication called belumosudil changes how the body absorbs it compared to swallowing it whole. It will involve 8 adult patients who have chronic graft-versus-host disease (cGVHD) after a stem cell transplant. The main goal is to check i…

This study is testing an experimental drug called ivonescimab to see if it can help control advanced kidney cancer that has continued to grow despite previous treatments. It will involve about 40 adults whose cancer has a clear cell type and has spread or cannot be removed by sur…

This study is testing an investigational drug called nirogacestat in adults with desmoid tumors, a rare type of non-cancerous but aggressive growth. The main goal is to understand why some people's tumors respond to the drug while others do not, by looking for specific biological…

This early-stage study is testing whether adding metal-detoxifying drugs to standard chemotherapy can help control acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Researchers want to see if lowering metal levels in the blood and bone marrow improves treatment res…

This study is testing a combination of three anti-cancer drugs to treat a rare and aggressive blood cancer called BPDCN. The goal is to see if using these drugs together is safe and can better control the disease and help patients live longer without it getting worse. The treatme…

This study is testing whether a combination of three drugs—avutometinib, defactinib, and cetuximab—can help control advanced colorectal cancer that has spread, cannot be surgically removed, and has stopped responding to standard anti-EGFR therapy. It will enroll about 33 adults t…

This is the first human study of an experimental oral medication called NP-101 for people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to test the safety and determine the right dose for future studies. Researchers will also loo…

This study is testing a new combination of three oral drugs (ASTX727, venetoclax, and gilteritinib) for adults with specific types of acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that have a genetic change called an FLT3 mutation. The first part aims t…

This early-stage trial is testing the safety and best dose of pembrolizumab, an immunotherapy drug, for people with advanced thymoma or thymic carcinoma that cannot be removed by surgery. The study aims to see if this treatment, which helps the body's immune system fight cancer, …

This early-phase study is testing a new drug, CBP-1019, in combination with several other cancer therapies for people with advanced solid tumors that have spread. The main goals are to find safe dose levels and see if these combinations can help shrink tumors. The study is enroll…

This study is testing whether adding very low doses of radiation can help targeted drugs work better for people with mantle cell lymphoma that has returned or hasn't responded to previous treatments. About 80 patients will receive one or two days of low-dose radiation before star…

This study is testing a combination of two drugs, azacitidine and quizartinib, for adults with advanced forms of blood and bone marrow cancers (like myelodysplastic syndromes). The goal is to find the safest and most effective dose and see if the combination can help control thes…

This study is testing if combining a targeted cancer drug called enfortumab vedotin with radiation therapy can help control locally advanced bladder cancer. It aims to see if this approach is safe, helps patients live longer without the cancer getting worse, and improves their qu…

This study is testing whether a drug called olutasidenib is safe and can help prevent cancer from returning in patients who have a specific genetic change (IDH1 mutation) in their blood cancer and have recently received a stem cell transplant. The drug is taken as a pill for up t…

This study is testing whether adding an immunotherapy drug (pembrolizumab) to standard chemotherapy and radiation improves outcomes for people with advanced squamous cell cancer in the nasal cavity or sinuses. The goal is to increase the number of patients whose tumors shrink sig…

This study is gathering information on a computer-assisted procedure to remove dangerous blood clots from the lungs of cancer patients. It aims to see if the procedure is safe and if it helps patients feel better and breathe easier. The study will follow 25 adult cancer patients …

This study is testing a targeted drug called enasidenib, sometimes combined with another drug (azacitidine), for people with a high-risk type of blood and bone marrow disorder called myelodysplastic syndrome (MDS) that has a specific genetic change (IDH2 mutation). The goal is to…

This study is testing whether giving a specific chemotherapy combination after surgery helps keep a rare and aggressive type of uterine cancer from returning. It will involve 48 patients whose cancer was fully removed by surgery but who are at high risk of it coming back. The mai…

This early-stage study is testing a new combination of two oral drugs, BMS-986504 and olaparib, in adults with advanced solid tumors that have a specific genetic change called MTAP loss. The main goal is to find a safe and tolerable dose. Researchers will also check how the drugs…

This study tests whether combining two medicines—enasidenib and azacitidine—can help control acute myeloid leukemia that has returned or hasn't responded to previous treatments. It's for patients whose cancer has a specific genetic change called an IDH2 mutation. Researchers want…

This study is testing a combination of two drugs, atezolizumab and cabozantinib, to see if they can help control advanced osteosarcoma (a type of bone cancer) in adolescents and young adults. The trial is for patients aged 12 and older whose cancer has come back or spread after s…

This early study is testing whether adding special cells from donated umbilical cord blood to the standard drug ruxolitinib works better than the drug alone. It aims to help cancer patients (ages 12-80) who develop a severe, steroid-resistant immune reaction called graft-versus-h…

This is a first-in-human study testing a new type of engineered immune cell therapy for patients with advanced soft tissue or bone sarcoma. The main goals are to find a safe dose and see if the treatment can help control the disease. The trial will enroll about 40 patients who ha…

This study aims to find out if a shorter, more intense course of radiation before breast cancer surgery works as well as the standard, longer course. It will involve 126 women who plan to have a mastectomy followed by tissue-based breast reconstruction. Researchers will compare p…

This study is testing whether a new drug called blinatumomab, given as an injection under the skin, works well and is safe when combined with lower-dose chemotherapy for older adults or those too frail for standard intensive chemotherapy who have a type of blood cancer called B-c…

This early-stage study is testing whether specially modified immune cells can safely help control serious viral infections in cancer patients with weakened immune systems. Researchers are collecting a patient's own T-cells, genetically engineering them to better target specific v…

This study is testing whether a drug called ivonescimab can help control a specific type of advanced breast cancer that has spread and no longer responds to standard hormone treatments. It will involve about 29 adults with metastatic invasive lobular carcinoma. The main goal is t…

This early-stage study is testing a new treatment for adenovirus infections in people with weakened immune systems, such as cancer patients. Doctors are giving patients specially grown immune cells (T-cells) from healthy donors that are trained to attack the adenovirus. The main …

This study is testing whether combining two medications—mosunetuzumab and zanubrutinib—can help control a type of blood cancer called marginal zone lymphoma that has come back or hasn't responded to previous treatments. The trial will enroll 36 adults to see how well the combinat…

This study is testing whether a combination of two drugs, obinutuzumab and CC-99282, can effectively control a specific type of blood cancer called follicular lymphoma in people who have not yet received any treatment for it. The trial is for adults with a high amount of cancer i…

This early-stage trial is testing whether adding a healthy donor's natural killer (NK) immune cells to two standard leukemia drugs can help control acute myeloid leukemia (AML). The study will enroll 32 adults with AML that has returned or not responded to prior treatment, or old…

This early-stage study is testing a new way to deliver a chemotherapy drug called gemcitabine. Patients with solid tumors that have spread to their lungs will breathe the drug as a mist using a special machine. The main goals are to find the highest safe dose and to understand th…

This early-stage trial aims to find a safe and effective dose of two drugs—gemcitabine and nab-sirolimus—when used together. It is for adults with advanced leiomyosarcoma or other soft-tissue sarcomas that have specific genetic changes (TSC1 or TSC2 mutations) and have stopped re…

This study is testing if a medicine called tranexamic acid, breathed in as a mist, can help control life-threatening lung bleeding in cancer patients who are on a breathing machine. It will compare this inhaled treatment to standard care to see if it improves survival at 28 days …

This study is testing a new 4-drug combination for people with advanced bile duct cancer that cannot be removed by surgery. Researchers want to see if adding a new drug called CTX-009 to the standard three-drug treatment is safe and helps control the cancer for longer. The study …

This study is testing the safety of an experimental virus therapy called G207 for children and young adults with recurrent or hard-to-treat brain tumors in the cerebellum. The virus is designed to infect and kill cancer cells while sparing healthy ones. Researchers will also test…

This study is testing if a low dose of the drug sirolimus is safe and can improve blood cell production in adults with RUNX1 familial platelet disorder. This inherited condition causes low platelets, easy bleeding, and a high risk of blood cancers. Researchers will see if the dru…

This study is testing whether a personalized cell therapy called obecabtagene autoleucel (obe-cel) can help control a high-risk type of blood cancer (B-cell ALL) when given after the first round of treatment. Researchers will give the therapy to about 30 adults with this specific…

This study is testing if a simple blood test can help doctors decide how much chemotherapy a patient needs before surgery for colorectal or appendix cancer. The test looks for tiny pieces of tumor DNA in the blood, which might show if the cancer is at high or low risk of coming b…

This study is testing a combination of a targeted cancer drug (inotuzumab ozogamicin), low-intensity chemotherapy, and an immunotherapy drug (blinatumomab) for adults with acute lymphoblastic leukemia (ALL). It focuses on older patients (60+) or younger patients who are too frail…

This study is testing whether combining four different cancer drugs can help control aggressive forms of blood and bone marrow disorders. It's for adults with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia, including those whose disease has returned afte…

This study is testing if adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine and cisplatin) helps people with a type of bile duct cancer in the liver stay cancer-free longer after surgery. The treatment is given both before and after the operation. R…

This study is testing whether the drug TAS-102, with or without the anti-inflammatory celecoxib, can clear tiny amounts of leftover cancer DNA from the blood of colorectal cancer patients. It's for people who have finished surgery and chemotherapy but still have detectable cancer…

This study is testing if two oral drugs, binimetinib and encorafenib, can help control melanoma that has spread to the brain or spinal fluid. It is for adults whose melanoma has a specific genetic change called BRAF V600 and has progressed after prior treatment. The main goals ar…

This study is testing if giving radiation therapy after starting immunotherapy drugs, but before surgery, can help shrink tumors and improve outcomes for patients with rare mucosal melanomas in the sinuses/nose or anus/rectum. It will enroll 40 adults whose cancer has not spread …

This study is testing a new two-drug combination for adults with two rare and serious blood cancers: myelofibrosis (MF) and chronic myelomonocytic leukemia (CMML). The main goals are to find the safest and most effective dose of the new drug axatilimab, both alone and when added …

This study is testing whether the drug luspatercept can help patients with a lower-risk form of myelodysplastic syndromes (MDS), a bone marrow disorder. The main goal is to see if the drug can safely reduce or eliminate the need for regular blood transfusions in these patients. R…

This early-phase trial is testing the safety and best dose of a combination of two targeted drugs, adagrasib and olaparib, for people with advanced solid tumors that have a specific genetic change called a KRAS G12C mutation. It will enroll about 52 adults with cancers like pancr…

This study is testing a combination of four drugs to see if they can improve blood counts in adults with aplastic anemia or low-risk myelodysplastic syndrome (MDS). The treatment aims to calm an overactive immune system that may be attacking the bone marrow, while also boosting w…

This study is testing whether a combination of two oral drugs, pirtobrutinib and venetoclax, can help control mantle cell lymphoma that has come back or stopped responding to other therapies. It will enroll about 30 adults whose cancer has relapsed or is refractory, including tho…

This study is testing whether adding radiation therapy can improve outcomes for patients with multiple myeloma whose cancer has returned after receiving CAR-T cell therapy. The research will enroll 30 adults who still show active disease on scans at least 30 days after their CAR-…

This study is testing if adding a drug called niraparib to standard hormone therapy after radiation treatment works better at controlling high-risk prostate cancer that is still in the prostate area or nearby lymph nodes. It will enroll about 200 men. The goal is to see if this c…

This study is testing a procedure to place a small tube (stent) in a blocked liver vein for patients with gastrointestinal cancers. The goal is to see if opening the vein is safe, helps keep it open, and improves patients' symptoms, nutrition, and overall well-being. Researchers …

This study is testing whether a new drug called ubamatamab, given alone or combined with an existing drug (cemiplimab), can help control two rare and aggressive cancers: renal medullary carcinoma and epithelioid sarcoma. It is for adults whose cancer has worsened after at least o…

This study is testing a new combination of targeted drugs for people with advanced blood cancers that have a specific genetic change called an IDH1 mutation. The main goals are to find the safest dose and see how well the drug combo works to control the cancer. The trial is for a…

This study is testing whether a combination of two existing cancer drugs can help control tumors that have spread to the brain. It is enrolling about 104 adults with specific cancers, including triple-negative breast cancer and non-small cell lung cancer, that have spread to the …

This early-stage study is testing a new, shorter radiation schedule called HYDRA for people with laryngeal (voice box) cancer. The main goal is to find the highest dose that is safe and tolerable for patients. Participants will receive the targeted radiation in just five sessions…

This study is testing if adding a drug called venetoclax to a patient's current ibrutinib or acalabrutinib treatment can help eliminate more cancer cells. It is for adults with high-risk chronic lymphocytic leukemia (CLL) who have been on one of those drugs for at least a year bu…

This study is testing a drug called ponatinib for adults with a type of blood cancer called chronic myeloid leukemia (CML). It's for patients whose cancer has not responded to or who could not tolerate other standard medications. The goal is to see if ponatinib can control the ca…

This study is testing a combination of two drugs, CPX-351 and quizartinib, to see if they can help control acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). The main goals are to find the safest and most effective dose and to see how well the treatment wo…

This trial is testing whether adding a newer targeted drug (quizartinib) to a standard three-drug chemotherapy cocktail works better for controlling aggressive blood cancers like acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). It is for adults (18-65 fo…

This study is testing if giving two immunotherapy drugs, cemiplimab and cetuximab, before a second surgery can help control cancer that has returned in the mouth. It aims to see if this approach is safe and can help keep the cancer from coming back after surgery. The study is for…

This study is for people with advanced bile duct cancer that started in the liver and has spread. It aims to see if adding precise, high-dose radiation therapy directly to the liver tumors, on top of the standard three-drug chemotherapy, helps patients live longer or better than …

This early-stage study is testing the safety and initial effectiveness of a new drug, rezatapopt, combined with an existing drug, azacitidine, for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The trial is specifically for patients whose cancer has a…

This study is testing whether adding targeted radiation to drug therapy helps control cancer that has spread to the brain. Researchers want to see if giving radiation right after drug therapy works better than waiting until tumors start growing again. The trial includes 316 adult…

This study aims to find a safe and effective dose of a two-drug combination (venetoclax and ASTX727) for children and teenagers whose acute myeloid leukemia (AML) has come back or hasn't responded to treatment. It will enroll up to 40 participants aged 2 to 18 years old. The main…

This study is testing a combination of three drugs—decitabine, venetoclax, and olutasidenib—for adults with acute myeloid leukemia (AML) that has a specific genetic change called an IDH1 mutation. The first part aims to find a safe and effective dose. The second part will see how…

This study is testing if targeted radiation can help control cancer that has spread and started growing again after treatment with immunotherapy drugs. It will involve about 230 adults with metastatic solid tumors or blood cancers. Researchers aim to see if this 'salvage' radiati…

This study is testing whether custom 3D-printed molds can help surgeons perform breast reconstruction more efficiently. The molds are designed using special computer algorithms to match each patient's body. Researchers will compare surgery time and outcomes between patients who r…

This study aims to see if adding a vitamin D cream (calcipotriene) to a standard skin cancer prevention cream (fluorouracil) works better for treating multiple actinic keratoses. Actinic keratoses are rough, scaly patches caused by sun damage that can sometimes turn into skin can…

This early-stage trial is testing the safety and best dose of a new two-drug oral combination (ziftomenib + quizartinib) for adults with a specific type of acute myeloid leukemia (AML) that has returned or not responded to prior treatment. The main goal is to see if the combinati…

This study is testing whether combining a personalized cell therapy called axicabtagene ciloleucel (a type of CAR T-cell therapy) with radiation treatment is safe for adults with follicular lymphoma that has returned or hasn't responded to at least two prior treatments. Researche…

This study is testing if a weight loss program using the drug tirzepatide is practical and safe for men to use before prostate cancer surgery. It will enroll 30 overweight or obese men with intermediate-risk prostate cancer and type 2 diabetes. The main goal is to see if particip…

This early-stage study is testing a new combination treatment for people with colorectal cancer who have had surgery but still have tiny amounts of cancer left in their blood. Researchers are giving patients specially engineered immune cells from donated cord blood, along with an…

This study is testing a combination of several cancer drugs to see if they can help control a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL) in children and young adults whose cancer has come back or did not respond to previous treatment. The trial will enr…

This study is testing if a very low dose of radiation can control a slow-growing blood cancer called marginal zone lymphoma. It will enroll 50 adults with early-stage disease. Doctors will give a small initial dose and only add more radiation if the cancer doesn't respond well en…

This study is testing if a drug called elranatamab can help control high-risk multiple myeloma when given both before and after a patient's own stem cell transplant. The goal is to see if this approach can eliminate any remaining cancer cells and keep the disease from returning. …

This early-stage study is testing a new cell therapy for adults with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that has come back or hasn't responded to other treatments. Doctors are giving patients specially engineered immune cells (called PRAME-TCR-NK cell…

This early-phase trial is testing the safety and best dose of the drug belantamab mafodotin for people with high-risk smoldering multiple myeloma, a condition where abnormal blood cells are present but haven't yet caused major symptoms. The study will enroll 30 participants to fi…

This study is testing whether a combination of two immunotherapy drugs, atezolizumab and tiragolumab, can help control high-risk bladder cancer when given before surgery to remove the bladder. It is for patients who are not eligible for the usual pre-surgery chemotherapy. The mai…

This study is testing whether a personalized immune cell therapy (called brexucabtagene autoleucel or brexu-cel) can help control B-cell acute lymphocytic leukemia (ALL) in adults. It is for people whose cancer has come back or didn't respond to treatment, or for those newly diag…

This study is testing whether adding a drug called talazoparib to standard hormone therapy (enzalutamide and ADT) is more effective at treating prostate cancer that has spread to nearby lymph nodes. The goal is to see if this combination can better control the cancer before patie…

This early-stage trial is testing whether adding a new drug called lurbinectedin to two existing cancer drugs (paclitaxel and bevacizumab) can help control advanced ovarian cancer that has stopped responding to standard platinum-based chemotherapy. The study will enroll 34 women …

This study is testing whether an experimental drug called SAR445877 can help control advanced non-small cell lung cancer in patients whose cancer has continued to grow despite previous immunotherapy treatment. The trial will enroll about 29 adults who have exhausted other standar…

This study is testing if an immunotherapy drug called cemiplimab can effectively control a specific type of colon cancer that has a DNA repair defect (dMMR/MSI-H). The goal is to see if the drug can shrink or eliminate the tumor enough that some patients might avoid having surger…

This study is testing a new three-drug combination for people newly diagnosed with advanced clear cell kidney cancer. The goal is to see if adding a targeted radiation drug to two existing cancer drugs is safe and can help control the disease. Researchers will enroll about 100 pa…

This study is testing whether combining two existing drugs, pembrolizumab and azacitidine, can help control Hodgkin's lymphoma that has returned or hasn't responded to other treatments. It will measure how well the combination shrinks tumors and how safe it is for patients, inclu…

This study is testing if adding a new targeted drug, sotorasib, to standard chemotherapy before surgery is safe and more effective for patients with a specific genetic type of lung cancer. It is for adults with stage IIA-IIIB non-squamous lung cancer that has a KRAS G12C mutation…

This study is testing a new drug called REGN5678 in men with high-risk prostate cancer that hasn't spread. The main goal is to see if the drug is safe and what side effects it might have. Participants will receive the drug before having their prostate surgically removed, so resea…

This study is tracking patients who receive radiofrequency ablation (RFA), a minimally invasive heat treatment, for benign or suspicious thyroid nodules and low-risk thyroid cancers. Researchers aim to learn about the long-term effectiveness of RFA and how it impacts patients' qu…

This early-stage study aims to find safe and effective doses of a new three-drug combination for adults with advanced forms of two specific leukemias. The trial will enroll about 30 people whose disease has not responded well to prior standard treatments. Researchers will test th…

This study is testing a new three-drug combination (valemetostat, rituximab, and lenalidomide) for adults with follicular lymphoma that has returned or stopped responding to prior treatment. The main goals are to find a safe and effective dose and to see how well the combination …

This study is testing a new treatment plan for adults with a specific type of lymphoma that starts in the chest, called primary mediastinal large B-cell lymphoma. The goal is to see if starting with two newer, targeted drugs and then adding standard chemotherapy is effective and …

This study aims to see if regularly checking blood for signs of heart injury can help prevent serious heart problems in cancer patients receiving immunotherapy. Researchers will monitor 980 adults getting standard immunotherapy treatment to see if this monitoring approach reduces…

This study is testing a second stem cell transplant using donated umbilical cord blood for patients whose high-risk blood cancer has returned after their first transplant. The goal is to see if using a less intense pre-transplant treatment can help control the disease and improve…

This study is testing whether adding the drug olutasidenib to standard chemotherapy can better control advanced blood cancers in patients who have a specific genetic mutation (IDH1). It aims to see if this combination is safe and effective at reducing the disease. The trial is fo…

This study is testing whether a drug called ivonescimab can help control advanced cutaneous squamous cell carcinoma, a type of skin cancer. Researchers will enroll 24 patients whose cancer cannot be removed by surgery or has spread. The main goals are to see if the drug shrinks t…

This study is testing whether combining the immunotherapy drug dostarlimab with an experimental drug called LB-100 can help control a specific, hard-to-treat type of ovarian cancer that has come back. It is for adults aged 18-75 whose cancer has returned after at least one prior …

This study is testing whether a combination of three drugs (pembrolizumab, carboplatin, and paclitaxel) can effectively shrink early-stage triple-negative breast cancer tumors before surgery. The goal is to see if this approach can help patients avoid more intensive chemotherapy …

This study is testing whether a two-drug combination (belantamab mafodotin plus lenalidomide) given as maintenance therapy after a patient's own stem cell transplant can help eliminate any remaining, hard-to-detect cancer cells in people with newly diagnosed multiple myeloma. The…

This is a first-in-human study to find a safe dose of a new oral drug called IACS-6274. It will be tested alone and in two different drug combinations in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check the safety …

This study is testing whether a drug called loncastuximab tesirine can help control large B-cell lymphoma in patients whose cancer has come back or didn't fully respond to previous treatments. The research focuses on people who showed a partial response after receiving CAR T-cell…

This study is testing whether a combination of four different immunotherapy and targeted therapy drugs can help control two types of B-cell lymphoma that have returned after prior treatment. It will enroll about 36 adults whose lymphoma has progressed despite at least one previou…

This is an early-stage study to find a safe and effective dose of a new cell therapy for people with advanced melanoma that has come back or stopped responding to standard treatments. Doctors will give participants immune cells (NK cells) that have been specially engineered in a …

This early-stage study is testing the safety of a wearable medical device that delivers low-intensity electric fields to the spine. It is for patients whose cancer has spread to the spine and has stopped responding to standard treatments like radiation or surgery. The goal is to …

This study is testing whether adding a special prebiotic-rich diet to standard immunotherapy helps patients with melanoma that can be surgically removed. Researchers want to see if the diet is easy for patients to follow and if it improves the body's response to the cancer drugs.…

This early-phase trial is testing a new treatment for advanced pancreatic cancer that has spread and carries a specific genetic change (KRAS G12D mutation). The treatment uses tiny natural packages from cells (called exosomes) to deliver a gene-silencing drug directly to the canc…

This study is testing a new drug called IVONESCIMAB for people whose glioblastoma brain cancer has returned after standard treatment. The first phase aims to find the safest and most effective dose. The second phase will see if that dose can help control the cancer's growth and e…

This study is testing if a new drug called zanzalintinib can shrink advanced thyroid tumors before surgery. The goal is to make the surgery safer and easier to perform for patients with complex, hard-to-remove cancers. Researchers will give the drug to about 45 adults, then measu…

This early-stage study is testing whether adding an HIV drug called nelfinavir to standard chemotherapy (cisplatin) and radiation can better control advanced vulvar cancer that cannot be removed by surgery. The main goal is to find the safest and most effective dose of nelfinavir…

This study is testing a new combination of two targeted drugs, naxitamab and sacituzumab govitecan, for people with metastatic triple-negative breast cancer (TNBC). The main goals are to find the safest and most effective dose of this drug pair and to see how well it shrinks tumo…

This study aims to see if it's safe and practical to give the drug methylnaltrexone to patients with oral cavity cancer for two weeks before their scheduled surgery. Researchers will enroll about 25 adults to see if they can complete the two-week drug course without major side ef…

This study aims to find the better drug combination for preventing graft-versus-host disease (GVHD), a serious complication, after a stem cell transplant for blood cancers like AML. Researchers will compare two different three-drug regimens in about 80 participants aged 65-75. Th…

This study is for adults whose brain cancer has returned after previous radiation treatment. It compares two approaches: receiving a second, precise radiation treatment after either surgery or laser therapy, versus just having close monitoring after those procedures. The main goa…

This study is testing a multi-step treatment plan for people with high-risk soft tissue sarcoma that can be surgically removed. The goal is to see if combining chemotherapy, an immunotherapy drug (atezolizumab), radiation, and surgery can help keep the cancer from coming back lon…

This study is testing whether a simple blood test can help doctors decide which patients need chemotherapy after surgery to remove colorectal cancer that has spread to the liver. The test looks for tiny pieces of cancer DNA in the blood. Patients with no cancer DNA might get less…

This study is testing an oral medication called avapritinib for people with advanced solid tumors that have spread and have specific genetic changes (mutations in the CKIT or PDGFRA genes). The drug aims to block the signals that help these tumor cells grow, potentially controlli…

This study is testing if a fecal microbiota transplant (FMT) can help treat gut-related side effects caused by antibiotics in lymphoma patients receiving a powerful cell therapy called CAR-T. Researchers will give FMT to some participants and compare their side effects and treatm…

This study is testing whether a supervised aerobic exercise program is practical and helpful for people with early-stage triple-negative breast cancer who are receiving immunotherapy before surgery. Researchers will work with 33 participants to see if they can stick to the exerci…

This study is testing a combination of three drugs—nivolumab, fluorouracil, and interferon—for people with advanced fibrolamellar carcinoma, a rare liver cancer that cannot be removed by surgery. The main goals are to see if the treatment is safe and if it can shrink tumors or st…

This early-stage study is testing whether combining two existing drugs, pembrolizumab and lenvatinib, can help control advanced stomach or gastroesophageal cancers that have spread or cannot be surgically removed. The trial is for adults whose cancer has continued to grow despite…

This study is testing whether combining four different cancer drugs works better than current treatments for adults with newly diagnosed acute myeloid leukemia (AML), a fast-growing blood cancer. About 145 participants will receive the drug combination in cycles to try to elimina…

This study is testing if a new combination of standard chemotherapy and two newer immunotherapy drugs works better as a first treatment for adults with B-cell acute lymphoblastic leukemia (ALL). The goal is to see if this approach helps patients stay cancer-free longer. The trial…

This study is testing whether adding a drug called isatuximab to the standard maintenance drug lenalidomide can better control high-risk multiple myeloma after a patient's own stem cell transplant. It will involve about 61 adults who have this aggressive form of the blood cancer …

This study is testing whether adding metal detoxification to standard chemotherapy helps control acute myeloid leukemia (AML) better than chemotherapy alone. Researchers will give 140 adults with intermediate or high-risk AML either standard treatment plus metal-removing drugs (C…

This study is testing whether older women with early-stage, low-risk breast cancer can safely skip hormone therapy (endocrine therapy) after surgery and radiation. It aims to see if radiation alone can effectively control the cancer while improving quality of life by avoiding the…

This study tests a personalized immune cell therapy for patients with blood cancers like leukemia, lymphoma, and myeloma. After receiving chemotherapy and a cord blood transplant, patients get infusions of natural killer (NK) cells—immune cells that may kill remaining cancer cell…

This study is testing whether combining two drugs, CPX-351 (a chemotherapy) and ivosidenib (a targeted pill), can help control a specific type of acute myeloid leukemia or high-risk MDS that has an IDH1 gene mutation. It will involve about 30 adults who are eligible for intensive…

This early-stage trial is testing whether taking oral medications can help keep acute myeloid leukemia (AML) from returning after patients achieve remission. The study will enroll 125 adults with AML who have responded to initial treatment but aren't candidates for stem cell tran…

This study aims to find the safest and most effective dose of a new drug, ziftomenib, when given with two other drugs (venetoclax and azacitidine) to children and young adults whose acute leukemia has come back or hasn't responded to other treatments. It will enroll about 22 part…

This early-stage study is testing a new two-drug combination for men with advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. The main goals are to find the safest and most effective dose and to see how well the body tolerates the …

This study aims to create personalized quitting plans for smokers. Over 2,000 participants will try different combinations of quit-smoking medications and counseling. If the first plan doesn't work, the study will adjust the treatment based on the person's traits to find what wor…

This study is testing whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—is safe and effective for people with two types of blood cancer who have not yet received treatment. It aims to see if this time-limited treatment can deeply reduce or eliminate…

This early-stage study is testing a new type of treatment for people with advanced head and neck cancer that has not responded to standard therapies. Doctors are giving patients specially engineered immune cells, called NK cells, which are designed to find and attack cancer. The …

This study is for people with esophageal or stomach cancer that has spread to only a few other places in the body. It compares two approaches: standard chemotherapy alone versus a more aggressive strategy that adds targeted radiation and possibly surgery to the chemotherapy. The …

This study is testing if using two antiviral flu medicines together works better than one alone for people with cancer or who have had a stem cell transplant. These patients have weaker immune systems, so flu can be more severe. Researchers want to see if the combination clears t…

This study is testing a new cell therapy for people with serious BK or JC virus infections. These viruses can cause severe problems in people with weakened immune systems, such as those with cancer, HIV, or a transplant. Doctors take virus-fighting immune cells from a donor, grow…

This study compares two methods for treating fluid buildup around the lungs in cancer patients. Researchers want to see if adding a medication called doxycycline to a standard drainage catheter helps patients finish treatment faster. About 208 participants will choose either the …

This study is testing a combination of several chemotherapy drugs to treat adults with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma. The goal is to see if adding the drugs nelarabine, pegaspargase, and venetoclax to a standard inten…

This large study is testing whether a less invasive 'keyhole' surgery works as well as traditional open surgery for women with advanced ovarian, fallopian tube, or primary peritoneal cancer. All participants receive chemotherapy before surgery. Researchers want to see if the mini…

This study is testing a yoga-based program designed specifically for Black adults to help them sit less, move more, and feel better mentally. Researchers will enroll 250 inactive Black adults from the Houston area to see if the program improves their quality of life and activity …

This study is testing whether a new immunotherapy drug called MGD019 can help control advanced cervical cancer that has spread or returned. It's for patients who haven't yet received chemotherapy for their advanced disease. Researchers will measure how well the drug controls the …

This study is testing whether a topical cream containing tofacitinib can safely and effectively treat early-stage cutaneous T-cell lymphoma, a rare type of skin cancer. The trial will enroll 20 adults whose cancer has returned or hasn't responded to at least one previous standard…

This trial is for people with advanced cancer that has spread but is only growing in a few spots. It compares two approaches: using targeted local treatments like radiation or surgery on those few growing spots versus switching to a new drug therapy. The goal is to see if treatin…

This early-stage trial is testing a new drug called Peposertib, given alongside standard radiation and chemotherapy, for people newly diagnosed with a fast-growing type of brain tumor (glioblastoma). The main goals are to find the safest dose of Peposertib and see if it can get i…

This study is testing if a special oxygen mask, called non-invasive ventilation, is better than standard high-flow oxygen at helping cancer patients with sudden, severe breathing problems. The main goal is to see if the mask can reduce the need for doctors to place a breathing tu…

This study is testing a two-step treatment for hairy cell leukemia, a rare blood cancer. First, patients receive a chemotherapy drug (cladribine) to kill cancer cells. Then, they receive an immunotherapy drug (rituximab) to help the immune system clean up any remaining cancer and…

This study is testing whether a combination of three drugs—calaspargase pegol-mknl, decitabine, and venetoclax—can help control aggressive T-cell blood cancers that have returned or not responded to prior treatment in patients aged 1 month to 21 years. The main goals are to see i…

This study is testing whether a more precise form of radiation therapy, guided by real-time MRI scans, can better control spinal tumors and improve patients' quality of life. It will involve about 40 adults with cancer that has spread to their spine. The goal is to see if this ad…

This study is developing and testing a video game designed to help young leukemia and lymphoma survivors after stem cell transplant. Researchers want to see if the game can encourage better health habits and improve recovery. They're gathering feedback from patients ages 15-39 to…

This study is testing whether adding a pill called ASTX727 to the standard drug dasatinib works better for people newly diagnosed with a slow-growing type of blood cancer called chronic myeloid leukemia (CML). The goal is to achieve a very deep remission, where the cancer is near…

This study is testing if an investigational drug called NKTR-255 can help restore the body's immune cells after patients with non-small cell lung cancer complete chemoradiation. The drug will be given alongside the standard immunotherapy durvalumab. Researchers want to see if thi…

This early-phase study is testing a new way to give the chemotherapy drug paclitaxel directly into the abdominal cavity for patients with advanced appendix cancer that has spread. The goal is to find a safe and effective dose and see if this direct delivery can shrink tumors and …

This study is testing whether combining two drugs, niraparib and dostarlimab, can help control advanced cancer that has spread to the brain. It will enroll 120 adults with specific types of cancer, including lung and breast cancer, who have active brain tumors that are growing. T…

This study is testing a new combination of drugs for adults with a specific, aggressive type of leukemia (Philadelphia chromosome-positive ALL) that has come back or hasn't responded to other treatments. The treatment combines an immunotherapy drug that helps the immune system fi…

This study is testing a combination of three drugs—pirtobrutinib, rituximab, and venetoclax—for adults who have never received treatment for mantle cell lymphoma, a type of blood cancer. The main goal is to see how many patients achieve a complete response, meaning no detectable …

This study is testing whether a pill called olutasidenib can help control certain early-stage blood disorders that have a specific genetic change (IDH1 mutation). It will involve about 15 adults with conditions like clonal cytopenia of undetermined significance (CCUS), lower-risk…

This study is testing a new combination of three drugs—azacitidine, venetoclax, and gilteritinib—for adults with certain aggressive blood cancers that have returned or not responded to treatment. The main goals are to find the safest dose and see if adding gilteritinib helps pati…

This study is testing whether shorter courses of radiation therapy are as safe and effective as standard, longer courses for breast cancer patients who have had surgery. It will enroll about 768 men and women at higher risk of their cancer returning. The main goal is to see if th…

This study is testing a two-part treatment for women whose mucinous ovarian cancer has returned. It involves surgery to remove visible tumors, followed immediately by a heated chemotherapy solution that is circulated in the abdomen to target any remaining cancer cells. The main g…

This study is testing an investigational drug called AMB-05X for people with colorectal cancer who have finished their main treatment and have no visible tumors, but still have a positive blood test indicating tiny amounts of leftover cancer. The goal is to see if AMB-05X can cle…

This study is testing if an immunotherapy drug called balstilimab can clear the HPV virus from the blood of throat cancer patients who have finished their main treatment but still show signs of the virus. The goal is to see if clearing this leftover virus can help prevent the can…

This study is developing personalized computer models to help surgeons plan the best way to remove pelvic tumors while preserving a patient's ability to walk. Researchers will analyze movement and imaging data from 130 adults before and after major pelvic surgery. The goal is to …

This study is testing whether a combination of two targeted drugs, tucatinib and T-DM1, can help control solid tumors that have spread to the brain. It is for adults with HER2-positive cancers that have metastasized. The main goal is to see if this drug combo can shrink or stop t…

This study is testing whether a CPAP breathing device (like those used for sleep apnea) can help keep lung tumors from moving during radiation treatment. Researchers want to see if using CPAP during radiation is more effective than having patients hold their breath, which is the …

This study is testing whether injecting a drug called nivolumab directly into high-risk precancerous spots in the mouth can stop them from turning into cancer. It will involve 45 adults with these lesions. The goal is to see if this targeted approach is safe and effective at prev…

This early-stage trial is testing whether a chemotherapy drug called bendamustine can safely prevent graft-versus-host disease (GVHD) in patients receiving stem cell transplants for blood cancers. GVHD occurs when donor cells attack the patient's body, and this study aims to find…

This study is testing whether adding specific prebiotic foods to the diet can improve gut health and help people with advanced melanoma respond better to their first-line immunotherapy treatment. Researchers will enroll 75 patients starting immunotherapy and provide them with a s…

This study is testing an oral drug called ONC201, alone or with another drug, for adults with advanced blood cancers that have returned or are not responding to standard treatments. The main goals are to find the safest and most effective dose and to see if the treatment can help…

This study is testing whether giving a high dose of the drug ruxolitinib, along with busulfan chemotherapy, before a stem cell transplant can help shrink an enlarged spleen and make the transplant more successful for people with myelofibrosis. Researchers will enroll about 30 pat…

This study is testing whether a combination of two immunotherapy drugs, nivolumab and relatlimab, can help control melanoma that has spread to the brain. It will enroll about 30 adults with active brain metastases who have not received certain prior treatments. The main goals are…

This study is testing a smartphone app called ApricityCare that helps patients report treatment side effects quickly. The goal is to see if catching problems early helps manage them better, so patients can stay on their cancer therapy longer. It is enrolling 425 adults with metas…

This study is testing a shorter, more intense form of radiation therapy for men with advanced prostate cancer. Instead of receiving radiation over several weeks, participants get just five high-dose sessions. The main goals are to see how safe this approach is and how it affects …

This study is testing a new, high-precision method to destroy liver tumors that have spread from colorectal cancer. The technique combines advanced imaging and computer software to guide the treatment and check that the entire tumor is covered. Researchers want to see if this mor…

This study compares two types of minimally invasive stomach cancer surgeries to see which one helps patients maintain their appetite and weight better after treatment. Researchers are looking at 20 patients with early-stage stomach or gastroesophageal cancer who need surgery with…

This study aims to find the best drug treatment to prevent cancer from returning after surgery for high-risk adrenocortical carcinoma, a rare and aggressive adrenal gland cancer. It will compare a single hormone-blocking drug against that same drug combined with two chemotherapy …

This study is testing if a medication called olanzapine can help reduce cravings for opioid painkillers in cancer patients. It will involve 87 adults with cancer pain who are already taking opioids and are showing signs of potential misuse. Participants will be randomly assigned …

This study is testing whether giving one or two drugs before surgery can better control a type of kidney cancer called clear cell renal cell carcinoma. It will compare belzutifan alone, pembrolizumab alone, or the two drugs together in about 10 patients with locally advanced canc…

This study is testing an investigational drug called zanzalintinib for adults with advanced bone sarcomas that have spread or returned after standard treatments. The main goals are to see if the drug can control the cancer's growth and for how long, and to monitor its safety. It …

This study is testing a combination of two chemotherapy drugs, CPX-351 and venetoclax, for adults with acute myeloid leukemia (AML) that has come back after treatment or did not respond to initial therapy. The main goal is to see if this combination can put the cancer into remiss…

This study is testing the safety and effectiveness of combining two drugs, gilteritinib and momelotinib, for adults with a specific type of acute myeloid leukemia (AML) that has a mutation called FLT3 and has come back or not responded to prior treatments. The first part of the s…

This study is testing whether an 8-week program of text messages can help adults reduce the time they spend sitting. Researchers will compare two types of text messages—scheduled reminders and responsive messages—to see which is more effective. The goal is to find a simple, acces…

This study is testing whether a specialized radiation technique can safely deliver higher doses to spinal tumors that have spread from other cancers. The approach aims to improve tumor control while carefully monitoring for any nerve damage. Researchers will enroll 60 patients wi…

This study is testing a shorter, more convenient radiation schedule for people with Merkel cell carcinoma, a rare and aggressive skin cancer. The goal is to see if giving higher doses of radiation over fewer visits is as effective at controlling the cancer and preventing it from …

This is a first-in-human study to check the safety of a new three-drug combination (Q702, azacitidine, and venetoclax) for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatments. The main goal is to find a safe dose and see what side effec…

This study is testing a special type of MRI scan called magnetic resonance elastography (MRE) to see if it can tell the difference between a brain tumor coming back and scar tissue from previous radiation treatment. The goal is to help doctors make more accurate diagnoses and bet…

This study is testing whether a new imaging method can help doctors better see and identify abnormal spots in the mouth. Researchers will apply a special dye and use special cameras to take pictures of mouth lesions in patients already scheduled for surgery. The goal is to see if…

This study is testing whether a new type of mammogram, called Contrast-Enhanced Mammography (CEM), is better than standard mammograms at finding breast cancer in women with dense breast tissue. It will enroll 1,000 women with dense breasts to compare the two methods. The goal is …

This study is testing a new imaging device that doctors can use during a needle biopsy. The device uses light to take pictures of tissue right before the biopsy needle takes a sample, helping to ensure the sample comes from the right spot. Researchers want to see if these picture…

This study aims to see if a newer type of scan called Molecular Breast Imaging (MBI) works as well as the standard MRI for detecting breast cancer in women at high risk. It will enroll 300 women who will get both scans to compare their accuracy. The goal is to find out if MBI cou…

This study aims to improve the diagnosis of different types of parathyroid tumors by analyzing stored tumor tissue and blood samples from past patients. Researchers will look for specific markers in the tissue to help doctors more accurately tell apart benign, atypical, and cance…

This study aims to determine if advanced MRI scans can better distinguish between true tumor growth and pseudoprogression (where treatment makes a tumor appear worse but it isn't actually growing) in adults with brain cancer. Researchers will compare detailed imaging results with…

This study is testing if a special type of mammogram called CESM is better than standard scans at finding the cause of unusual nipple discharge. CESM uses a safe dye injected into the vein to make breast tissue clearer on the images. The goal is to see if this method can more acc…

This study is testing a new imaging agent to see if it helps doctors better diagnose glioma, a type of brain tumor. Adult patients who are already scheduled for brain tumor surgery will receive the agent before a special MRI scan. The main goal is to see if the pictures from this…

This study is testing a new, specialized type of MRI scan to see if it can better measure how well chemotherapy is working for patients with colorectal cancer that has spread to the liver. The scan is done before and after a few rounds of chemo to see if changes in the scan image…

This study is testing a new type of PET scan that uses a special tracer called 18F-FSPG. The goal is to see if this scan can better find and map out liver cancer in patients who are scheduled for surgery or a liver transplant. Researchers will compare this new scan to current sta…

This study is testing a new type of imaging scan called PYLARIFY PET-CT. The goal is to see if it can more accurately detect when cancer has spread (metastasized) in patients with pancreatic, liver, or breast cancer. Researchers will compare the new scan's results to current stan…

This study is testing new brain scan software designed to help surgeons better plan brain tumor removal. The software creates detailed maps of critical brain areas for language and movement to help avoid damaging them during surgery. Researchers will compare the new software's ac…

This study is testing a new imaging device called the Active Biopsy Guidance System to see if it can help doctors make better decisions about when and where to take tissue samples from suspicious mouth lesions. The device uses special light and a safe dye to highlight abnormal ar…

This study is testing whether combining four different blood tests can help detect ovarian cancer at its earliest stages in women at average risk. Researchers will enroll 8,000 postmenopausal women to track their blood marker levels over time. Based on the results, participants m…

This study aims to test new, potentially faster and simpler methods for detecting cervical cancer and pre-cancer in women in Mozambique. It will enroll 678 women who have already received a positive result from a standard screening test. Researchers will compare the accuracy of a…

This study is comparing two ways of creating mammogram images to see which helps doctors better spot breast cancer. Researchers will look at the medical records and past scans of 750 women to analyze the performance of a newer image type called 'synthetic mammography' against the…

This study is testing two different 3D mammography machines to see which one gives doctors clearer pictures of suspicious areas in the breast, like lumps or tissue distortions. It will involve 100 women who are already scheduled for a regular screening mammogram. Researchers will…

This study is testing a new type of mammogram that uses a safe dye injected into the vein to make breast tissue clearer. The goal is to see if this enhanced scan can better identify which suspicious-looking areas are cancer and help doctors target the right spot for a biopsy. It …

This study is testing whether a special type of MRI scan can predict which head and neck cancer patients will develop serious jawbone damage after radiation treatment. Researchers will follow 300 patients at high risk for this complication, performing regular MRI scans and tracki…

This study aims to develop a better way to diagnose type 3c diabetes, which is caused by pancreatic cancer or chronic pancreatitis. Researchers will give participants a standardized meal drink and measure their body's hormone responses to see how they differ from regular type 2 d…

This study is testing whether a special type of MRI scan can help doctors predict which head and neck cancer patients might develop serious jawbone damage (osteoradionecrosis) as a side effect of their radiation treatment. Researchers will follow 1,400 patients, taking MRI scans …

This study is testing a new screening questionnaire to see if it can better identify cancer survivors who need occupational therapy. Researchers will compare the new tool to the current standard used in a rehabilitation clinic. The goal is to make sure survivors who struggle with…

This study is testing a new, simpler HPV test designed to be used right in a clinic. Researchers want to see if this new test gives the same results as the standard, more complex HPV tests. The goal is to help develop easier and more accessible screening tools for human papilloma…

This study aims to see if offering at-home self-collection test kits for cervical cancer screening, along with education for patients and doctors, can help more women get screened. It will involve about 7,100 women in Texas who are due for their regular screening. The main goal i…

This study is testing whether advanced MRI scans can help doctors target the most aggressive parts of brain tumors during needle biopsies. Researchers will compare biopsy results from areas identified by advanced MRI versus standard imaging in 50 adults with suspected brain tumor…

This study is testing if a special type of PET-CT scan using a tracer called Axumin can help doctors better understand brain metastases in patients on immunotherapy. It aims to tell the difference between real cancer growth and harmless swelling that looks like growth on standard…

This study is testing a new type of PET scan to see if it can tell doctors how well a patient's esophageal cancer is responding to chemotherapy and radiation. Researchers want to know if this scan can detect the cancer and show treatment effects earlier than current methods. The …

This study is comparing two types of MRI scans used to diagnose prostate cancer. It aims to see if a new, more comfortable external coil is as good at finding aggressive cancer as the standard internal coil. The goal is to improve the accuracy of diagnosis and help doctors plan t…

This study is testing a new type of MRI scan to see if it can help doctors tell the difference between harmless and potentially cancerous pancreatic cysts. The research involves 20 adults who already have a pancreatic cyst and are scheduled for surgery to remove it. Participants …

This study is testing whether having a partner makes it easier for inactive women to start exercising regularly. Researchers will compare women who exercise with a friend or family member to women who try to increase activity on their own. The goal is to see if social support hel…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and education through mobile mammography units. It will enroll 1,000 underserved women in Texas who are already scheduled for a mammogram. The goal is to…

This study is testing whether a drug called letermovir can prevent the CMV virus from reactivating in cancer patients receiving a specific type of immunotherapy called CAR-T. The trial will enroll 36 adults who have previously been exposed to CMV and are scheduled for CAR-T thera…

This study aims to understand and potentially prevent a common side effect of chemotherapy called peripheral neuropathy, which causes pain, numbness, and tingling. Researchers are enrolling 45 adults with breast cancer who are starting certain chemotherapy drugs. They will track …

This study compares two different surgical stitching methods used to close the abdominal wall after liver tumor removal surgery. Researchers want to see if a newer 'small bite' stitching technique can better prevent incisional hernias (a hole or bulge in the abdominal wall) than …

This study aims to create a web-based educational tool to help women and their healthcare providers make informed decisions about preventing endometrial (uterine) cancer. The tool will focus on the option of using a hormone-releasing intrauterine device (IUD) as a primary prevent…

This study is testing if performing a special bypass procedure during lymph node removal surgery can prevent a painful, chronic swelling condition called lymphedema. Researchers will observe 20 adult patients undergoing this surgery to see if the early intervention is safe and ef…

This study is testing if a drug called canakinumab can prevent lung cancer in people who have suspicious, high-risk spots (nodules) in their lungs. About 50 participants will receive injections of the drug every 3 weeks for up to 8 cycles. The main goal is to see if the drug can …

This study is testing if two common medications—pentoxifylline with vitamin E or pravastatin—can prevent or reduce painful swelling and scarring (lymphedema and fibrosis) that often occurs after radiation treatment for head and neck cancer. The trial will enroll about 295 adults …

This study is testing whether rebuilding the body's lymph drainage system right after lymph node removal for breast cancer can prevent a painful, chronic swelling condition called lymphedema. It will follow 50 women for two years to see if this immediate surgical repair keeps the…

This study is testing whether performing a special surgical connection, called a lymphovenous bypass, at the same time as standard underarm lymph node removal can prevent a painful and chronic side effect called lymphedema (arm swelling). The research involves 252 adults with adv…

This study is testing a new community-based approach to help more women get screened for cervical cancer. Community health workers will visit women in low-resource areas of Texas to offer at-home HPV test kits and support. The goal is to see if this method is practical and accept…

This study is testing a new way to combine cervical cancer screening with family planning services in Mozambique. It aims to see if offering these services together makes it easier for women to access both types of care. The research will involve about 14,600 women aged 30-49 or …

This study is testing a new approach to prevent ovarian cancer in women with specific genetic mutations that put them at high risk. Currently, the standard prevention is to remove both fallopian tubes and ovaries at a relatively young age, which causes immediate menopause. This s…

This study is testing whether two common over-the-counter pain relievers, aspirin or naproxen, can help prevent cancer in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. Researchers will give 40 participants one of the drugs for a year and use …

This study is testing a peer-led support course designed specifically for Black women who have survived breast cancer. Researchers want to see if this community-based program improves participants' quality of life by addressing social and environmental challenges. The study invol…

This study is testing whether psilocybin (a compound found in 'magic mushrooms'), combined with psychotherapy, can help reduce depression and anxiety in people who have survived cancer. It will involve about 20 participants and aims to check if the treatment is safe and practical…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with psychotherapy, can help reduce depression and anxiety in people with advanced cancer. It will involve 30 participants who are receiving ongoing cancer treatment. Researchers will mea…

This study compares three approaches for chronic knee pain: standard steroid injections, nerve stimulation with steroid injections, and nerve stimulation with placebo injections. Researchers want to see which method works best for improving knee movement and reducing pain over 90…

This early-stage study is testing whether a single, highly focused dose of radiation to a small gland in the brain (the pituitary) can help relieve severe pain in cancer patients. It is for people whose pain is not controlled by standard treatments like opioids or surgery. The ma…

This study explores whether a virtual group writing program can help young adult cancer survivors improve their quality of life. Researchers will work with 30 participants aged 18-39 who finished cancer treatment 1-5 years ago. The program involves four writing sessions designed …

This study aims to see if combining talk therapy (CBT) with light therapy, medication, or melatonin can help improve sleep quality, fatigue, anxiety, and depression in people with advanced cancer. Researchers will compare these active treatments against placebo (inactive) treatme…

This study is testing whether writing about personal experiences can improve quality of life and reduce stress for Asian American cancer survivors. Researchers will enroll 192 adults who have completed their primary cancer treatment within the last 5 years. Participants will writ…

This study is testing a structured program that provides personalized oxygen therapy and other supportive treatments to help hospitalized cancer patients who are experiencing significant shortness of breath. The goal is to see if this approach can reduce the severity of breathles…

This study aims to find out if patients can safely go home the same day after thyroid surgery instead of staying overnight in the hospital. Researchers will compare recovery, pain levels, and safety between the two approaches in 224 adults having thyroid surgery. The goal is to u…

This study is testing whether ustekinumab can help control severe diarrhea and colon inflammation that sometimes occurs as a side effect of cancer immunotherapy drugs. Researchers will give ustekinumab to 10 cancer patients experiencing these complications to see if it reduces sy…

This study is testing three different nerve surgery techniques to see which works best for reducing chronic pain and phantom limb pain in adults who have had an amputation due to cancer. Participants will be randomly assigned to receive one of the surgical procedures. Researchers…

This study is testing whether a short, personalized video can reduce anxiety for brain cancer patients and their caregivers during radiation treatment. The video uses the patient's own brain scan to explain their specific tumor and potential symptoms. Researchers want to see if t…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help reduce severe diarrhea and colon inflammation caused by cancer immunotherapy drugs. The trial will enroll 40 patients with various cancers who developed these …

This study is testing a drug called domperidone for people with severe, chronic stomach disorders like gastroparesis and reflux disease who haven't gotten better with standard treatments. The drug aims to help the stomach empty food more quickly, which may reduce symptoms like pa…

This study is testing two different video-based support programs to see if they can improve psychological wellbeing and quality of life for people with advanced cancer and their family caregivers. Researchers will enroll 400 patient-caregiver pairs who are experiencing significan…

This study is testing whether a yoga program for patients and their caregivers can improve physical function and quality of life during radiation treatment for lung or esophageal cancer. It will compare yoga sessions to educational sessions to see which helps patients walk farthe…

This small pilot study is testing whether a special spinal cord stimulator can help people with severe nerve pain caused by chemotherapy. The device is designed to automatically adjust its electrical pulses to help control pain, reduce medication use, and improve walking. Researc…

This study is testing if a simple writing exercise can help cancer survivors manage stress, which can be made worse by events like the COVID-19 pandemic. About 414 adult cancer survivors will be randomly assigned to either write about their personal experiences or about neutral t…

This study is testing whether a supervised, remote exercise program can reduce severe fatigue in young adults who have survived brain cancer. Researchers will enroll 75 survivors aged 18-39 who are struggling with fatigue and are less than five years out from treatment. The goal …

This pilot study is testing whether helping patients identify what matters most to them can improve management of chemotherapy-induced nerve pain. The trial involves 45 adult cancer survivors who experience significant nerve pain from past chemotherapy. Researchers will evaluate …

This small study at MD Anderson Cancer Center is testing whether a device that gently stimulates nerves can help reduce pain caused by chemotherapy. It will involve 10 adults who have finished chemo within the last year but still have significant leg pain. The main goal is to see…

This study is testing a virtual group therapy program designed to help cancer survivors. It aims to reduce anxiety and depression, improve quality of life, and help people find meaning after cancer. Researchers will enroll 72 participants to understand their experiences with this…

This study is testing a new, less invasive procedure to help people with cancer that has spread to their pelvic bone. Doctors insert special light-activated nails to strengthen the weakened bone. The main goal is to see if this improves patients' ability to walk and move, and red…

This study is testing a new mobile app that guides lung cancer patients and their family caregivers through yoga exercises. The goal is to see if the app is easy to use and helpful for managing stress and improving quality of life during radiation treatment. Researchers will enro…

This study aims to find out if certain medications can help treat or prevent lymphedema (swelling) and fibrosis (scarring) caused by radiation therapy in head and neck cancer survivors. Researchers will test different drugs in 250 participants to see which one is most effective a…

This study aims to understand and reduce post-traumatic stress disorder (PTSD) in women undergoing gynecologic brachytherapy treatment. Researchers will test methods to improve patient comfort during the removal of radiation implants. The study involves 36 participants and focuse…

This study is testing whether combining education and counseling with a placebo pill works better than education alone to reduce fatigue in people with advanced cancer. Researchers want to see if this combination improves quality of life, mood, sleep, and thinking for 240 patient…

This study is testing whether having a nurse use hypnosis before and during breast cancer surgery can help patients need less opioid pain medication afterward. Researchers are comparing three approaches: hypnosis with local anesthesia, hypnosis before standard anesthesia, and sta…

This small, early-stage study is testing whether a patch containing capsaicin (the compound that makes chili peppers hot) can help relieve pain and improve walking in people with nerve damage caused by chemotherapy. Researchers will measure changes in pain levels, walking speed, …

This study is testing whether a simple digital art activity helps adult cancer patients better express their symptoms and emotional distress. Researchers will compare the art activity to listening to music to see which helps patients communicate their experiences more openly. The…

This early study is testing whether alteplase, a drug that dissolves blood clots, can help cancer patients breathe easier. It focuses on patients who have a build-up of fluid around their lungs that won't drain properly through a permanent catheter, causing severe shortness of br…

This study is developing and testing a short, 5-session support program designed to improve the emotional wellbeing and quality of life for people caring for a loved one with advanced cancer. Researchers want to learn what kind of support is most helpful for caregivers. The goal …

This study is testing a new support program for parents who have advanced cancer that has spread or returned. The program provides education and video sessions to help parents manage stress, talk to their children about cancer, and improve family wellbeing. It is for patients wit…

This study is testing whether a reward-based exercise program can help children and young adults with cancer stay active during a stem cell transplant. Participants earn stickers for walking and other activities, which they can trade for rewards. Researchers want to see if this a…

This study is testing whether listening to live or recorded music before brain surgery can help reduce patients' stress, anxiety, and pain. Researchers will measure changes in vital signs, blood markers, and patient questionnaires in 132 adults. The goal is to see if music is a h…

This study is testing a special recovery program designed to help patients leave the hospital sooner after minimally invasive liver surgery. The program combines specific surgical techniques, pain management plans, and remote check-ins to support safe recovery at home. Researcher…

This study is testing a new counseling program called Focused Acceptance and Commitment Therapy (FACT) to see if it helps people with advanced cancer manage their fear and anxiety about death. The researchers want to know if the program is practical, acceptable to patients, and i…

This study is testing whether combining a brain-training therapy called neurofeedback with a medication (duloxetine) works better than either treatment alone for relieving nerve pain caused by chemotherapy. About 380 cancer survivors with this type of pain will be assigned to rec…

This study tests a specialized geriatric care program designed to help older adults who have finished curative treatment for early-stage breast cancer. The program involves comprehensive health assessments, personalized follow-up visits, and activity tracking to address physical,…

This study is testing whether having a structured conversation about a patient's goals and wishes for care during an emergency room visit improves their quality of life. It involves 200 adults with advanced lung or gastrointestinal cancer who are not expected to be cured. Researc…

This study is testing a website and app called 'Project Prepare' to see if it helps throat cancer patients stick to their prescribed swallowing and jaw exercises during radiation treatment. The goal is to prevent or reduce long-term swallowing problems, a common and serious side …

This study aims to develop and test a yoga therapy program designed to be culturally sensitive for cancer patients undergoing stem cell transplants. The program will be offered to 60 patients in the United States, India, and Tanzania to see if it helps reduce depression and stres…

This study tests whether a lifestyle program focused on the whole family helps Black men who have finished prostate cancer treatment. It compares a program that includes both the survivor and a family caregiver to one for the survivor alone and a control group. The goal is to see…

This study is testing a spiritual support program called PEACE, led by a chaplain and a clinician, for people with advanced cancer. The goal is to see if the program is practical and helpful for patients, and if it can help them manage how their spiritual or religious beliefs aff…

This study is testing whether a custom-made, 3D-printed mouth guard can help reduce painful mouth sores and blisters in people receiving radiation therapy for head and neck cancers. About 119 patients will be randomly assigned to either use the guard during their standard radiati…

This early-stage study is testing whether a non-invasive brain stimulation technique called rTMS can help people with obesity control excessive eating. Researchers will recruit 30 adults to see if the treatment is safe, tolerable, and feasible to deliver. The main goal is to gath…

This study aims to find the best medication to calm severe agitation and restlessness (called agitated delirium) in hospitalized cancer patients. Researchers are comparing three different calming drugs against a placebo (a treatment with no active drug), along with standard comfo…

This study is testing a comprehensive yoga therapy program for women with ovarian cancer who are scheduled for chemotherapy and surgery. Researchers want to see if this lifestyle program is practical to implement and if it helps improve patients' quality of life, physical conditi…

This study aims to find out if a more precise, high-dose form of radiation therapy (SBRT) is better at relieving pain from cancer that has spread to bones than the standard radiation treatment. It will enroll 220 adults with painful bone metastases from solid cancers. The main go…

This study is testing a specific nerve transfer surgery to see if it can improve facial movement and quality of life for head and neck cancer patients who have facial paralysis. Researchers will enroll 40 patients to measure changes in their facial function and daily life after t…

This study is testing if a shorter, more intense course of radiation can better relieve pain and control tumors in patients with advanced head and neck cancer who cannot be cured. It will compare this new approach to standard, longer radiation schedules. The main goal is to see w…

This study is testing whether a shared exercise program is practical and acceptable for patients with non-small cell lung cancer who are receiving radiation therapy and their family caregivers. It aims to see if the program can improve physical function and quality of life for bo…

This study is testing if a special vacuum dressing helps abdominal wounds heal better after breast reconstruction surgery in patients with obesity. It compares the vacuum dressing to standard bandages. The goal is to see if the vacuum dressing reduces wound complications and impr…

This study is testing a non-drug treatment called Scrambler Therapy to see if it can safely reduce pain and improve daily life for adolescents and young adults who have nerve damage from chemotherapy. Participants will be randomly assigned to receive the therapy right away or aft…

This study is testing a new program that provides food and online cooking lessons to cancer survivors who struggle to afford healthy meals. The goal is to see if this 'Food Farmacy' approach is practical and if it helps improve people's diets, food security, and overall well-bein…

This study is collecting medical information from 2000 patients with low-grade ovarian or peritoneal cancers to build a comprehensive database. Researchers will review medical records and store tissue samples to better understand these specific tumor types. The goal is to analyze…

This study surveys radiology residents to understand how comfortable they feel performing simulated blood vessel procedures after training on a virtual reality simulator. The goal is to see if this type of hands-on practice in a risk-free environment helps prepare doctors for rea…

This study aims to understand why some people with early, symptom-free blood cell conditions (MGUS or smoldering myeloma) develop full multiple myeloma while others don't. Researchers will follow 200 patients for 3 years, collecting blood samples and tracking their health to iden…

This study aims to see if special CT scans taken before and during cancer treatment can help doctors predict how well chemotherapy will work for patients with pancreatic or liver cancers. Researchers are enrolling 259 people with these cancers who are scheduled to receive standar…

This study is testing a specialized MRI scan to see if it can effectively assess the spinal cord. Researchers will scan healthy volunteers and a small group of patients with a specific spinal condition to gather baseline information. The goal is to improve future methods for eval…

This study collects detailed information about side effects experienced by cancer patients receiving proton radiation therapy. Researchers will follow 5,000 patients to understand both short-term and long-term effects, aiming to predict risks and improve safety for future patient…

This study aims to identify early warning signs of lung inflammation (pneumonitis) in patients with non-small cell lung cancer who receive combined chemotherapy, radiation, and immunotherapy. Researchers will collect blood, saliva, and stool samples from 150 participants and moni…

This study aims to understand a specific type of cell found in patients with bronchiolitis obliterans syndrome (BOS), a serious lung condition that can occur after a stem cell or lung transplant. Researchers will collect cell samples from 15 patients during their routine medical …

This study aims to find out if a less frequent follow-up schedule causes less anxiety for patients who have had surgery for soft tissue sarcoma. Researchers will compare two groups: one having scans every 3 months and another having scans every 6 months. The main goal is to see w…

This study aims to understand how the COVID-19 pandemic impacted the mental, financial, and social well-being of adolescent and young adult cancer patients and survivors. Researchers will survey about 600 participants to measure their stress, healthcare use, and life disruptions …

This study aims to find out if a simpler method of tracking only high-calorie, low-nutrient snacks is a reasonable and easier alternative to logging all foods and drinks. Researchers will compare how well people stick with and like using the simple 'MySnackTracker' app versus a t…

This study aims to understand why some oral cancers are more aggressive and how patients respond to treatment. Researchers will collect tissue samples and health data from 1000 adults with oral cancer or pre-cancer before, during, and after their standard treatments. The goal is …

This study aims to understand and compare the stress experienced by surgeons and musicians during their work. Researchers will measure stress using wearable brain sensors, saliva tests for stress hormones, and standard questionnaires. The goal is to gather information about occup…

This study is testing whether simple blood tests, called liquid biopsies, can predict if endometrial (uterine) cancer will come back after treatment. Researchers will collect blood samples from 1,000 women with endometrial cancer at different points during their treatment to trac…

This study aims to see if regular MRI scans after radiation treatment can predict bone damage in patients with head or neck cancers. Researchers will follow 425 patients, taking MRI scans at specific times after treatment to look for early signs of tissue changes. The goal is to …

This study aims to understand how social and financial factors, like income and support systems, influence the results of transplant and cell therapy treatments. Researchers will observe 2,000 adult patients at MD Anderson Cancer Center who are candidates for or have received the…

This study aims to understand how different questionnaires measure side effects from radiation therapy. Researchers will ask head and neck cancer patients to complete several surveys about their symptoms during or after treatment. The goal is to learn which survey methods work be…

This study asks brain cancer patients about their experiences with telemedicine versus in-person doctor visits. Researchers want to understand if patients feel they receive the same quality of care through video appointments. The study involves 200 patients completing surveys and…

This study aims to understand the mental and emotional impact of the COVID-19 pandemic on employees at a major cancer hospital. It will enroll up to 20,000 staff members to complete online surveys about their stress and well-being during and after the pandemic. The goal is to gat…

This study is creating an educational tool to help patients with advanced cancer, their caregivers, and doctors have better conversations about treatment options. It focuses on patients who have already tried at least two rounds of therapy and are considering more. The goal is to…

This early study is testing a tiny, rice-sized device that can be implanted into a sarcoma tumor. The device releases tiny amounts of 10 different cancer drugs directly into the tumor tissue. The goal is to see which drugs affect the tumor cells, helping doctors learn which treat…

This study aims to understand how lifestyle factors like mental health, diet, exercise, and social support are linked to quality of life and health outcomes in people with melanoma. Researchers will enroll 5,000 patients who will complete questionnaires about their habits and wel…

This study aims to understand the quality of life, treatment experiences, and healthcare costs for cancer patients receiving long-term blood clot treatment. Researchers will follow 260 participants for one year, collecting survey responses about their daily experiences and review…

This study aims to understand the experiences of cancer patients who develop arthritis or muscle pain as side effects of immunotherapy. Researchers will interview 20 patients who developed these symptoms after cancer treatment. The goal is to learn how these side effects affect d…

This study aims to understand how whole brain radiation therapy affects memory, thinking, and quality of life in patients with blood cancers like lymphoma and leukemia. Researchers will follow 100 adult patients for up to 5 years, using standard memory tests, questionnaires, and …

This large observational study aims to better understand what causes chronic pancreatitis and how it progresses over time. Researchers are following 2,345 participants at 9 major medical centers across the US, including people with pancreatitis, abdominal pain, and healthy contro…

This study aims to update and test educational materials that help heavy smokers understand their options for lung cancer screening. Researchers will interview current and former smokers to get feedback on the materials and test questionnaires about lung cancer knowledge. The goa…

This study is testing an educational tool designed to help older men with prostate cancer who are on active surveillance (watchful waiting). The tool aims to help these men and their doctors decide if and when it might be safe to reduce the frequency of cancer monitoring tests li…

This study aims to collect information from women getting routine mammograms to build a large database for future research. It will enroll 10,000 women without a history of breast cancer to gather their mammogram images, blood samples, and health information annually for five yea…

This early-phase study aims to find out if the experimental drug ulixertinib can cross the blood-brain barrier and reach recurrent brain tumors called gliomas. It will enroll about 40 adults and teenagers (12+) whose tumors have a specific genetic change (MAPK-activated). The mai…

This study aims to get expert doctors to agree on the most important information that should be consistently recorded in prostate cancer patient charts. A small panel of specialists will complete several rounds of surveys to reach a consensus. The goal is to create a standard rep…

This study aims to understand what breast cancer survivors know about chemicals found in common personal care products like cosmetics and shampoos. Researchers will interview 30 survivors from a specific community program to learn about their interest in this topic. They will als…

This study is testing a new online tool designed to help women with early-stage breast cancer make informed decisions about surgery. The tool provides clear information about the risks of cancer in the other breast and the potential benefits of removing it preventively. Patients …

This study is creating and testing a new questionnaire system to better understand the symptoms cancer patients experience and how those symptoms impact their daily lives and quality of life. Researchers will enroll thousands of patients, caregivers, and healthcare providers to c…

This study aims to understand if patients would be willing to join a future research trial. That future trial would compare standard genetic counseling to a more personalized approach for people with or at risk for Li-Fraumeni Syndrome. Researchers are asking 500 people to comple…

This study is creating and testing a Spanish-language decision aid for ovarian cancer patients. The tool is designed to help Spanish-speaking patients better understand their maintenance therapy options and participate in choosing their treatment. Researchers will test the tool w…

This early-phase study aims to see if it's safe and possible to collect a person's own blood-forming stem cells when they have RUNX1 familial platelet disorder. Researchers will enroll a small number of adults with this inherited condition to undergo a procedure that collects the…

This study is creating a large collection of medical information and biological samples from people with inflammatory breast cancer. Researchers will gather blood, tissue, stool samples, and health data from up to 1,200 participants. The goal is to build a research resource that …

This is the first study in people to test the safety and behavior of a new imaging dye called 18F-4FN. The dye is designed to light up areas of inflammation in the body during a PET scan. Researchers will give the dye to 55 adults with cancer or suspected inflammation to see wher…

This study is testing whether data from wearable activity monitors (like Fitbits) can be collected from cancer patients and used by doctors. Researchers want to see if a patient's daily activity levels are connected to their overall health status and survival. The goal is to gath…

This study aims to understand what helps or hinders a positive hospital stay for Asian cancer patients. Researchers will survey 520 former patients who identify as Asian and received cancer care at MD Anderson, along with their healthcare providers. The goal is to identify specif…

This study aims to collect leftover fluid and tissue samples from routine lung procedures to build a large research bank. The goal is to help scientists study many different lung conditions in the future. It involves collecting samples that would otherwise be discarded after a pa…

This study aims to understand why inherited colon cancer syndromes can cause different types and severities of cancer among family members. Researchers will collect health questionnaires and DNA samples (blood or saliva) from about 2,000 patients and their relatives. The goal is …

This study aims to understand if a special care program for lung cancer patients under 50 improves their satisfaction with care and meets their unique needs. Researchers will enroll 75 participants to track their experience, quality of life, and use of support networks over time.…

This study analyzes cancer patients' tumor tissue and blood samples to identify specific genetic changes in their cancer. The goal is to create a detailed database of cancer mutations and use that information to match patients with the most relevant treatment options and clinical…

This study aims to understand women's perspectives and knowledge about endometrial (uterine) cancer risk and prevention options. Researchers will interview 45 women—some with cancer, some at risk, and some healthy—to learn about their attitudes. The goal is to create better educa…

This study aims to understand how the way doctors present medical information—like risks, benefits, costs, and life expectancy—affects the treatment choices of people with advanced cancer. Researchers will use written scenarios to test different ways of sharing this information w…

This study is testing if a special online training program (called Project ECHO) can help doctors and nurses in rural and underserved areas provide better comfort and symptom care (palliative care) for people with advanced cancer. It will measure if patients' quality of life and …

This early-stage study is testing a new type of PET scan (called 18F-FAraG PET) to see if it can better detect tumors in people with esophageal cancer. The main goal is to learn if this scan can predict whether a patient's cancer will completely disappear after receiving standard…

This study aims to understand the long-term safety of gene transfer therapy by tracking the health of people who have received it. Researchers will follow up to 130 participants for 15 years, collecting health updates and blood samples to look for any delayed effects, good or bad…

This study aims to understand the financial stress patients experience due to the cost of cancer care after surgery for bone or soft tissue tumors. Researchers will survey 100 adult patients to measure how common and severe this financial burden is. The goal is to learn how this …

This study is testing a brain mapping technique called electrocorticography (ECoG) during surgery to remove brain tumors. The goal is to see if this method can better identify the brain areas responsible for movement and speech, helping surgeons avoid damaging them. Researchers w…

This study is testing whether measuring changes in a patient's pupil size and reaction can predict when serious neurological side effects might start after they receive CAR-T cell therapy for lymphoma. Researchers will monitor 100 adult patients receiving this cancer treatment at…

This study aims to understand the side effects that occur in cancer patients receiving anti-VEGF therapies, which are common cancer treatments. Researchers will observe 170 patients with advanced cancer to see if there's a connection between these side effects and how well the tr…

This study aims to find the best ways to use tobacco quitlines to educate heavy smokers about lung cancer screening. It involves training quitline staff and then referring eligible smokers to educational materials. Researchers will measure how well the information is delivered an…

This study is creating a registry to collect and analyze information from lung cancer patients who undergo a minimally invasive, robot-assisted procedure to destroy small tumors in the lungs. The main goal is to gather data on how safe the procedure is and how well it controls th…

This study aims to understand how radiation and chemotherapy for advanced lung cancer affects heart health over time. Researchers will follow 100 patients receiving personalized treatment plans, measuring heart fitness and injury markers before, during, and for years after treatm…

This study aims to understand why some head and neck cancer patients follow, and others skip, prescribed swallowing exercises after radiation therapy. Researchers will collect blood samples and ask patients to fill out questionnaires to see if factors like mood, pain, immune syst…

This study aims to understand what happens to people long-term after being diagnosed with rare skin cancers called mycosis fungoides or lymphomatoid papulosis as children or teenagers. Researchers will contact 100 former patients (or their parents) to track their health status, t…

This study aims to understand how long-term tamoxifen treatment affects certain immune cells called neutrophils in breast cancer patients. Researchers will collect blood samples from 290 women with estrogen-positive breast cancer who have been taking tamoxifen for different lengt…

This study is testing whether taking more frequent MRI scans during radiation and chemotherapy treatment for aggressive brain tumors (high-grade gliomas) can help doctors see how the tumor is changing. By spotting changes earlier, doctors might be able to adjust the radiation tre…

This early-stage study is testing whether a special type of MRI scan can predict how patients with thyroid or other head and neck cancers will respond to their treatment. The scan uses a special imaging agent to look at how cancer cells use energy. Researchers hope this scan can …

This study is testing whether a simple blood test can find tiny amounts of leftover cancer cells after treatment. Researchers want to see if this test can predict if colorectal cancer will come back or spread earlier than current scans and check-ups. The study involves collecting…

This study looks back at the medical records of 600 patients who had lung cancer surgery between 2004 and 2019. The goal is to understand if and how the introduction of robotic surgery has changed the types of lung-removing operations surgeons perform. Researchers are comparing r…

This study aims to understand why certain powerful cancer drugs (immune checkpoint inhibitors) can shrink tumors but sometimes cause serious heart problems. Researchers will follow 1,200 patients starting this therapy, analyzing their blood and genetics to find clues that predict…

This study aims to discover what causes bile duct and gallbladder cancers and why treatments work differently for different people. Researchers will compare 1,500 participants, including cancer patients, healthy people, and people with liver disease. They will collect blood and t…

This study aims to create a large database of medical information from patients with a very rare type of uterine cancer called mesonephric-like adenocarcinoma (MLA). By collecting details about patients' characteristics, treatments, and outcomes, researchers hope to better unders…

This small pilot study aims to understand how a person's diet might change the bacteria in their gut and whether those changes could lead to cell damage that starts colon cancer. Researchers are comparing people who eat vegetarian diets with those who eat omnivorous diets. Partic…

This study is creating and testing a decision-making guide for people with medullary thyroid cancer. The tool helps patients and their caregivers understand their options—like starting or stopping new drugs, joining clinical trials, or continuing regular monitoring—so they can ha…

This study is testing a new type of lung scan to better understand and measure breathing problems that can occur after a stem cell transplant. Researchers will compare the new scan results with standard breathing tests and CT scans in 25 adult transplant patients. The goal is to …

This study is testing if a special PET scan and a blood test can help doctors predict how well a radiation treatment will work for liver cancer. Researchers will enroll 60 patients who are scheduled to receive the standard radiation therapy. The goal is to see if these new tests …

This study aims to learn more about children who get repeated or long-term pancreatitis. Researchers will collect blood, saliva, urine, and stool samples from up to 1,600 children under 18 to look for genetic signs that might show who is at higher risk for developing pancreatic c…

This study aims to create and test easy-to-understand educational videos and materials about lung cancer screening, specifically for patients in safety-net healthcare systems. The researchers will work with current and former smokers to adapt the information and then test if the …

This study aims to better understand how advanced medullary thyroid cancer develops and affects patients over time. Researchers will use a large existing patient registry and ask about 2,030 participants to complete regular questionnaires about their health, quality of life, and …

This study is creating and testing an educational website to help people understand how to prevent liver cancer. Researchers will work with 40 participants to make sure the website is easy to understand and use. The goal is to develop a tool that clearly explains liver cancer ris…

This study aims to learn about the symptoms and challenges patients face during and after treatment for tumors in the sinuses, nasopharynx (upper throat), or skull base. Researchers will follow 300 adult patients receiving most of their care at MD Anderson to track their quality …

This study aims to understand the quality of life and anxiety experienced by patients with early-stage blood conditions called MGUS and smoldering myeloma. It involves 400 patients who are already in other related studies at MD Anderson. Participants will fill out questionnaires …

This study is testing a new screening tool designed to help patients with advanced lung cancer better understand their illness and communicate their care preferences. Researchers will compare the tool against usual care for 100 patients to see if it leads to more informed discuss…

This study aims to learn from the experiences of thousands of chronic myeloid leukemia (CML) patients who were treated with standard drugs like imatinib by their local doctors, not in a formal research trial. Researchers will review past medical records to understand how treatmen…

This study aims to test whether specific sensory tests and skin biopsies can reliably measure nerve pain caused by cancer treatments like chemotherapy. Researchers will enroll 450 people, including cancer patients with treatment-related pain, those starting treatment, and healthy…

This study is testing a new dye used in PET/CT scans to see if it can help doctors better see and understand chronic graft-versus-host disease (GVHD). Researchers will give the dye to 16 adult patients who have chronic GVHD affecting their joints and then perform scans. The main …

This study tests whether a 'Teaching the Teachers' approach helps spread liver cancer diagnosis guidelines more widely. It involves training expert radiologists, who then teach the guidelines to other doctors. Researchers will track how often these guidelines are taught and used …

This study aims to understand how the COVID-19 pandemic affects the financial burden on breast cancer patients undergoing surgery. Researchers will survey 600 patients about out-of-pocket costs, lost wages, and economic strain before and after their operations. The goal is to ide…

This study collects information from patients with blood cancers who receive two advanced treatments: CAR-T cell therapy and radiation therapy. By reviewing medical records and imaging scans, researchers aim to understand how these treatments work together and which patients bene…

This study is a global registry that aims to understand how patients with advanced thyroid cancer respond to standard treatments outside of traditional clinical trials. It will track survival and quality of life in about 459 patients to identify barriers to care and see how well …

This study aims to collect information from patients with Von Hippel Lindau (vHL) disease to better understand how the disease develops over time. Researchers will track tumor growth, treatment history, and quality of life in 125 participants. The goal is to identify patterns tha…

This study is creating a detailed registry to track how patients recover after surgery to remove the bladder for cancer treatment. Researchers will collect information from 2,000 patients about their symptoms and recovery experiences. The goal is to establish a baseline so future…

This study is a nationwide survey asking lung doctors how their practices changed during the COVID-19 pandemic. Researchers want to learn how hospitals adapted their staffing, procedures, and outpatient care. The goal is to use this information to guide better responses to future…

This study aims to understand how radiation treatment for esophageal cancer affects patients' ability to respond to pneumonia vaccines. Researchers will compare vaccine responses in 80 cancer patients and healthy individuals to see if radiation weakens immune protection. The goal…

This study aims to understand how patients function and live their lives after major surgery to remove pelvic bone cancer. Researchers will follow 200 patients for up to 10 years, tracking their mobility, pain, and quality of life. The goal is to learn the long-term effects of th…

This study aims to understand what people like and find useful in a mobile app for tracking food and drinks. Researchers will hold small group discussions and interviews with about 39 adults who have recently finished a weight loss program. The feedback will help doctors and app …

This study aims to identify Black individuals and families in Houston, Texas who may be at increased risk for hereditary breast and colorectal cancers. Researchers will work with trusted community organizations to screen 1,000 participants using a simple questionnaire. Those iden…

This study is testing a new radioactive dye for PET/CT scans to see if it can better show cancer cells in people with solid tumors, including ovarian, breast, and other cancers. Researchers want to see if this new imaging method can help measure a specific protein activity inside…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study aims to collect information from people with inflammatory breast cancer who have had a specific blood test to look for tiny amounts of leftover cancer cells. Researchers want to see if finding these cells before surgery can help predict if the cancer might come back. T…

This study is testing a blood test to see if it can help doctors monitor lymphoma patients. The test looks for tiny pieces of cancer DNA in the blood before and after treatment. Researchers want to see if this test can predict how well treatment is working and if any cancer cells…

This study aims to understand how the COVID-19 pandemic affected melanoma patients' quality of life, stress levels, and access to healthcare. Researchers will survey over 1,100 patients who previously participated in a lifestyle study to learn about their pandemic experiences. Th…

This study aims to find biological markers (biomarkers) that may help predict how well a new drug combination works for people with advanced solid tumors. Researchers will test the drugs SAR444881 and cemiplimab in 40 participants and collect tissue and blood samples to look for …

This study is creating a registry to collect information from breast MRI scans. Researchers want to learn if MRI is a better tool than mammograms for monitoring younger women (50 and under) with a history of breast cancer and dense breast tissue, which can hide cancer on a standa…

This study aims to understand whether a patient's ancestry and economic status affect their ability to find a well-matched bone marrow donor and receive a transplant. Researchers will follow 1,200 adult cancer patients who are candidates for this procedure. The goal is to identif…

This study aims to see if cancer clinics will successfully adopt a specific tool, called DIGEST, to measure swallowing difficulties in their patients. It will involve 85 clinics that regularly perform swallowing tests on cancer patients. The goal is to understand the best ways to…

This study aims to find out if measuring a patient's fitness level before major cancer surgery can help predict how well they recover afterward. Researchers will test lung and esophageal cancer patients using exercise breathing tests before and after their pre-surgery treatments.…

This study is creating a registry to collect information from 750 patients with a rare and aggressive type of cervical cancer called neuroendocrine carcinoma. Researchers will review medical records and follow patients for up to 10 years to understand how different treatments aff…

This study aims to understand what cancer doctors, patients, and their family caregivers think about the idea of receiving hospital-level cancer care at home. Researchers will conduct interviews and focus groups to gather opinions and identify potential challenges. The goal is to…

This study aims to understand how caregivers and healthcare providers perceive discomfort in advanced cancer patients who have hypoactive delirium (a state of reduced awareness and responsiveness) and are near the end of life. Researchers will enroll 100 patients and their caregi…

This study collects leftover nerve tissue from patients having spinal tumor surgery. Researchers will test new nano-based pain treatments on these nerve cells in the lab. The goal is to understand pain mechanisms and identify potential future treatments, but this is early researc…

This study aims to understand how sleep and physical activity change for patients and their primary caregivers after a bone marrow transplant. Researchers will give Fitbits to 66 patient-caregiver pairs to track their activity and sleep patterns during and after the hospital stay…

This study aims to understand why some cancer patients develop severe diarrhea and colon inflammation (colitis) while taking powerful immunotherapy drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 patients with melanoma…

This study aims to better understand a rare form of cervical cancer called clear cell carcinoma. Researchers will review the medical records and stored tumor tissue from about 70 patients previously treated at MD Anderson Cancer Center. The goal is to describe the disease's chara…

This study aims to understand and compare the symptom burden and quality of life in people who have both cancer and heart failure. Researchers will enroll 100 participants who have completed cancer treatment within the last three years and have a confirmed heart failure diagnosis…