Cold virus engineered to attack brain tumors shows promise in early trial

NCT ID NCT03896568

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 24 times

Summary

This early-stage trial tests a modified cold virus (DNX-2401) that is designed to target and kill brain cancer cells. The virus is loaded into donor stem cells and injected into the artery that feeds the tumor. The study includes 36 adults with recurrent high-grade glioma and aims to find the safest dose while monitoring side effects and tumor response.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • M D Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-••••

    Contact

Conditions

Explore the condition pages connected to this study.