New trial tests chemo combo to stop rare adrenal Cancer's return
NCT ID NCT03583710
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether adding chemotherapy (cisplatin and etoposide) to the standard drug mitotane after surgery works better than mitotane alone for patients with adrenocortical carcinoma at high risk of recurrence. The study plans to enroll 240 adults with stage I-III disease who had their tumor removed. The main goal is to see which approach delays or prevents the cancer from coming back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mitotane, cisplatin, etoposide
What this could lead to
If successful, this could show that adding chemotherapy to mitotane after surgery reduces the chance of adrenocortical carcinoma coming back in high-risk patients.
What could go wrong
This is an early-stage Phase 3 trial with only 240 participants, so results may not apply to all patients. Chemotherapy adds significant side effects, and it's unclear if the combination is better than mitotane alone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Akademiska Sjukhuset
RECRUITINGUppsala, Sweden
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Angers, Hôpital Larrey
RECRUITINGAngers, 49933, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Besançon, Hôpital Jean Minjoz
RECRUITINGBesançon, 25000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Bordeaux - Hôpital Haut Lévèque
RECRUITINGPessac, 33600, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Brest, Hôpital La Cavale Blanche
ACTIVE_NOT_RECRUITINGBrest, 29200, France
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CHU Nantes, Hôpital René et Guillaume Laënnec
ACTIVE_NOT_RECRUITINGNantes, 44093, France
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CHU Nantes, Hôpital René et Guillaume Laënnec
RECRUITINGNantes, 44093, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Poitiers
RECRUITINGPoitiers, 86000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Reims
RECRUITINGReims, 51092, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Toulouse, Hôpital Larrey
RECRUITINGToulouse, 31059, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Toulouse, Hôpital Rangueil
ACTIVE_NOT_RECRUITINGToulouse, 31400, France
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Centre Georges François Leclerc
RECRUITINGDijon, 25000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gustave Roussy
RECRUITINGVillejuif, 94805, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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HCL Hôpital Louis Pradel
NOT_YET_RECRUITINGLyon, 69877, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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HUS, Hôpital Hautepierre
NOT_YET_RECRUITINGStrasbourg, 67000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital COCHIN
ACTIVE_NOT_RECRUITINGParis, 75014, France
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Hôpital Cochin
RECRUITINGParis, 75014, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Cochin, AP-HP
RECRUITINGParis, 75014, France
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Hôpital Cochin, AP-HP
ACTIVE_NOT_RECRUITINGParis, 75014, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut de Cancérologie de l'Ouest (ICO)
ACTIVE_NOT_RECRUITINGAngers, 49055, France
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Karolinska University Hospital
RECRUITINGStockholm, Sweden
Contact Phone: •••-•••-•••• Email: •••••@•••••
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LMU Klinikum München
RECRUITINGMunich, 80336, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Lyon HCL
RECRUITINGLyon, 69002, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Maria Sklodowska-Curie National Research Institute of Oncology
ACTIVE_NOT_RECRUITINGGliwice, 44-102, Poland
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Marseille Hôpital Nord
RECRUITINGMarseille, 13015, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Marseille Hôpital de la Conception
RECRUITINGMarseille, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sahlgrenska University Hospital
RECRUITINGGothenburg, Sweden
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Siteman Cancer Center at Washington University
ACTIVE_NOT_RECRUITINGSt Louis, Missouri, 63110, United States
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Skånes Universitetssjukhus
RECRUITINGLund, Sweden
Contact Email: •••••@•••••
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Strasbourg HUS Hautepierre
ACTIVE_NOT_RECRUITINGStrasbourg, 67000, France
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University of Michigan Comprehensive Cancer Center
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Email: •••••@•••••
Contact
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Universitätsklinikum Würzburg
RECRUITINGWürzburg, 97080, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact