Less invasive surgery may improve recovery for ovarian cancer patients

NCT ID NCT04575935

Recruiting now Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two surgical approaches for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who have received chemotherapy before surgery. One group will have minimally invasive surgery (small incisions), and the other will have standard open surgery (larger incision). The goal is to see if the less invasive method works as well or better at delaying cancer return and improving quality of life. About 580 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Minimally invasive surgery (laparoscopy)
What this could lead to: If successful, this could show that a less invasive surgery works as well as open surgery, helping patients recover faster with less pain and a better quality of life after treatment.
What could go wrong: This is a large Phase 3 trial, but it is still possible that minimally invasive surgery may not control the cancer as effectively as open surgery, or that benefits are small. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube clear cell adenocarcinoma fallopian tube endometrioid tumor fallopian tube neoplasm fallopian tube serous adenocarcinoma fallopian tube transitional cell carcinoma ovarian cancer ovarian carcinoma ovarian clear cell adenocarcinoma ovarian endometrioid adenocarcinoma ovarian serous adenocarcinoma ovarian transitional cell carcinoma primary peritoneal serous adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

Amsterdam UMC - Locatie AMC | H5Zuid 154
RECRUITING

Amsterdam, Netherlands
Arthur J.E. Child Comprehensive Cancer Centre - Calgary
RECRUITING

Calgary, Canada
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Cleveland Clinic Foundation - Florida
RECRUITING

Weston, Florida, 33331, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke
RECRUITING

Durham, North Carolina, 27710, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, 00168, Italy
Houston Methodist
RECRUITING

Houston, Texas, 77030, United States
Instituto Nacional de Cancerología (Mexico)
RECRUITING

Tlalpan, Mexico
Lyndon Baines Johnson General
RECRUITING

Houston, Texas, 77026, United States
M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
NYU Langone Health
RECRUITING

Mineola, New York, 11501, United States
Sant'Orsola Hospital di Bologna
RECRUITING

Bologna, 40138, Italy
St. Luke's University Health Network
RECRUITING

Bethlehem, Pennsylvania, 18015, United States
University Health Network - Princess Margaret Cancer Centre
RECRUITING

Toronto, Canada
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Wisconsin Carbone Cancer Center
ACTIVE_NOT_RECRUITING

Madison, Wisconsin, 53792, United States

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