Experimental nanoparticle boosts radiation against esophageal cancer
NCT ID NCT04615013
First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 4 times
Summary
This early-phase trial tests a new drug called NBTXR3, which is injected into the tumor and activated by radiation to destroy cancer cells. It is given alongside standard chemotherapy for people with stage II–III esophageal adenocarcinoma. The main goals are to find the safest dose and see if the combination is tolerable. Only 24 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NBTXR3 (a nanoparticle drug activated by radiation)
- What this could lead to
- If it works, this could point toward a new way to enhance radiation and chemotherapy for esophageal cancer, potentially improving tumor control.
- What could go wrong
- This is a very early Phase 1 trial with only 24 participants, focused on safety and dosing. It may not lead to a proven treatment, and side effects from the combination therapy are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CERVICAL ESOPHAGUS ADENOCARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can AI-Guided home training boost recovery from gastric cancer surgery?
- Can a new drug combo shrink Hard-to-Treat tumors?
- Can an immunotherapy combo shrink stomach tumors before surgery?
- Can adding immunotherapy to chemotherapy improve gastric cancer outcomes?
- Can a smart drug home in on Hard-to-Treat cancers?
- Could a smartphone program supervised by AI boost recovery after stomach cancer surgery?