Simple blood test may spot ovarian cancer sooner

NCT ID NCT00539162

Recruiting now Diagnosis Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether combining the standard CA125 blood test with other tumor markers can help detect ovarian cancer earlier in women who are at low risk. Researchers will track 8,000 postmenopausal women over time, repeating blood tests and sometimes ultrasound if markers rise. The goal is to improve early detection, but this is an observational study, not a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple blood test that catches ovarian cancer earlier, when it's easier to treat.
What could go wrong: This is an observational study, not a treatment trial. It may not prove that early detection saves lives, and false alarms could cause unnecessary worry or procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ovarian cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

Carol G. Simon Cancer Center / Atlantic Health
RECRUITING

Morristown, New Jersey, 07962, United States
John Stoddard Cancer Center
RECRUITING

Des Moines, Iowa, 50309, United States
Sylvester Comprehensive Cancer Center, Univ of Miami Miller School of Medicine
RECRUITING

Miami, Florida, 33136, United States
The University of Texas at Austin
ACTIVE_NOT_RECRUITING

Austin, Texas, 78712, United States
UT Health Science Center San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55454, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Texas (UT) Southwestern Medical Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Women's Hospital of Texas, Obstetrics and Gynecology Associates (OGA)
RECRUITING

Houston, Texas, 77054, United States
Women's and Infant's Hospital
RECRUITING

Providence, Rhode Island, 02905, United States

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