New hope for liver metastases: Y-90 radiation before surgery may boost candidacy

NCT ID NCT05195710

Recruiting now Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 1 trial is testing whether injecting tiny radioactive beads (Y-90) into the right side of the liver can shrink tumors and make the left side grow larger, so more patients with colorectal cancer liver metastases can have potentially curative surgery. The study will enroll 50 patients whose liver is too small for safe surgery. Researchers are primarily checking if the procedure is safe and feasible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Yttrium-90 (Y-90) resin microspheres
What this could lead to: If successful, this approach could make more patients eligible for curative liver surgery by shrinking tumors and growing healthy liver tissue.
What could go wrong: This is an early phase 1 trial with only 50 participants, so safety and feasibility are still being tested. The procedure may not work for everyone and carries risks like radiation damage to healthy tissue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METASTASES are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

metastatic neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTASES

Contacts and locations

Locations

M D Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.