New combo aims to control lung cancer that returns after standard therapy
NCT ID NCT04892953
First seen Jun 24, 2026 · Last updated Aug 11, 2026 · Updated 3 times
Summary
This phase II trial tests whether adding local treatments like surgery or radiation to the immunotherapy drug durvalumab can help control stage III non-small cell lung cancer that has progressed after chemoradiation and durvalumab. About 51 participants with 3 or more growing tumors will receive the combination. The goal is to see if this approach can delay further cancer growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Durvalumab (immunotherapy) plus local therapy (surgery or radiation)
- What this could lead to
- If successful, this approach could offer a way to control advanced lung cancer that has started to grow again after initial treatment.
- What could go wrong
- This is a small, early-phase trial with only 51 participants, so results may not apply broadly. The combination may cause side effects or not improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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